Nitric oxide donors as treatment for grass induced acute laminitis in ponies

Equine Veterinary Journal

Volumn 28, Issue 1, 1996, Pages 17-28

  Hinckley, K A ^a   Fearn, S ^a,b   Howard, B R ^a   Henderson, I W ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b JOHNSON AND JOHNSON   (United States)

Author keywords

Arginine; glyceryl trinitrate; Horse; Laminitis; Nitric oxide

Indexed keywords

EQUIDAE; EQUUS CABALLUS;

ARGININE; GLYCERYL TRINITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; VASODILATOR AGENT;

ACUTE DISEASE; ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR FUNCTION; CARDIOVASCULAR SYSTEM; DRUG EFFECT; FOOT DISEASE; HEART RATE; HEMODYNAMICS; HOOF AND CLAW; HORSE; HORSE DISEASE; INTRADERMAL DRUG ADMINISTRATION; INTRAVENOUS DRUG ADMINISTRATION; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; POACEAE; SPECTROPHOTOMETRY; VASODILATATION;

ACUTE DISEASE; ADMINISTRATION, CUTANEOUS; ANIMALS; ARGININE; BLOOD PRESSURE; CARDIOVASCULAR PHYSIOLOGY; CARDIOVASCULAR SYSTEM; FOOT DISEASES; HEART RATE; HEMODYNAMIC PROCESSES; HOOF AND CLAW; HORSE DISEASES; HORSES; INJECTIONS, INTRAVENOUS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITROGLYCERIN; POACEAE; SPECTROPHOTOMETRY; VASODILATION; VASODILATOR AGENTS;

EID: 0029688089     PISSN: 04251644     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.2042-3306.1996.tb01586.x     Document Type: Article

References (51)

1. Anggård, E E. (1990) The endothelium - the body's largest endocrine gland? J. Endocrinol. 127, 371-375.
2. Baxter, G (1992) Equine lamimtis Equine Pract. 14, 13-22.
3. Baxter, G. (1994a) Effects of tumor necrosis factor on in vitro digital arterial responses in horses. Am. J. vet. Res. 55, 551-555.
4. Baxter, G (1994b) Alterations in endothelial-dependent digital vascular responses in horses given low dose endotoxin. In. Proceedings of Colic Symposium Oct 1994. Georgia, USA. p 14.
5. Baxter, G., Laxley, R E, Tackett, R L, Moore, R.L and Allen, D. (1989) In vitro reactivity of digital arteries and veins to constructive mediators in healthy horses and in horses with early lamimtis. Am. J. vet. Res. 50, 508-517 .
6. Baudouin, S.V., Bath, P., Martin, J.F., Du Bois, R. and Evans, T.W. (1993) L-arginine has no effect on systemic haemodynamics in normal volunteers, or systemic and pulmonary haemodynamics in patients with elevated pulmonary vascular resistance. Br J Clin. Pharmacol 36, 45-49
7. Berrazueta, J R , Salas, E , Flietas, M G , Poveda, JJ., Ochoteco, A and Amando, J.A. (1994) Anti-inflammatory and analgesic action of transdermal glyceryl trinitrate In. Biology of Nitric Oxide 4. Enzymology, Biochemistry and Immunology Eds: S. Moncada, M Feelisch, R. Busse and E.A. Higgs. Portland Press, London pp 424-427
8. Böger, R M , Bode-Boger, S M , Tsikas, D and Frölich, J.C (1994) Intravenous L-arginine induces nitric oxide formation and increases peripheral arteriolar blood flow in healthy humans. In. The Biology of Nitric Oxide 3. Physiological and Clinical Aspects Eds: S Moncada, M. Feelisch, R Busse and E A. Higgs Portland Press, London, pp 466-471
9. Brunon, M, Antoni, E and Wilson, M.T (1981) Cytochrome C oxidase: An overview of recent work. In. Metal Ions in Biological Systems 13. Ed. H. Sigel. Marcel Dekker Inc., New York and Basel. pp 188-218
10. Clarke, L L. (1982) Renin-Angiotensin Aldosterone System of the Horse. MSc Thesis, University of Missouri, Columbia, USA
11. Creagher, A M., Gallagher, S J., Girerd, X.J., Dzau, V J and Cooke, J.P. (1992) L-arginine improves endothelium-dependent vasodilation in hypercholesterolemic humans J. clin Invest 90, 1248-1253.
12. Coffman, J R, Johnson, J.H., Guffy, M M. and Finnochio, E J. (1970) Hoof circulation in equine laminitis. J. Am vet med Ass. 156, 76-83
13. Elliott, J. Bryant, C E. and Soydan, J. (1994) The role of nitric oxide in the responses of equine digital veins to vasodilator and vasoconstrictor agents Equine vet. J. 26, 378-384
14. Essenpries, M., Cope, M, Elwell, C.E , Arridge, S.R., van der See, P. and Delphy, D T. (1993) Wavelength dependence of the differential path length factor and the log slope in time resolved tissue spectroscopy. In: Optical Imaging of Brain Function and Metabolism Ed: U Dirnagl. Plenum Press, New York, pp 9-20.
15. Fessler, J.F., Bottoms, G D and Roesel, O.P., (1982) Endotoxin induced change in haemograms, plasma enzymes and blood chemical values in anaesthetised ponies: Effects of flumxin megulamine. Am. J. vet Res. 43, 140-144.
16. Fickling, S.A, Leone, A.M , Nussey, S.S., Vallance, P. and Whiteley, G St J. (1993) Synthesis of NG Dimethylarginine by human endothelial cells. Endothelium 1, 137-141.
17. Furchgott, R.F. and Zawadsi, J.V (1980) The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Nature 288, 373-376.
18. Galey, F D., Twardock, A.R., Goetz, T.E., Shaeffer, D.J., Hall, J.O. and Beasley, V R (1990) Gamma scintigraphic analysis of the distribution of perfusion of blood in the equine foot during black walnut (Julans nigra) induced laminitis Am J vet. Res. 51, 688-695.
19. Goodman, L.S. and Gilman, A. (1970) The Pharmacological Basis of Therapeutics, 4th edn. Macmillan, London, New York p 750.
20. Griffith, T.M. (1994) Modulation of blood flow and tissue perfusion by endothelium-derived relaxing factor. Exp. Physiol. 79, 873-913.
21. Hampson, N. and Piantodosi, C. (1988) Near infrared monitoring of human skeletal muscle oxygenation during forearm ischacmia J. appl. Physiol 64, 2449-2457.
22. Hinckley, K.A. and Henderson, I.W. (1995) Plasma endothelins in normal and acutely laminitic horses J. Endocrinol. 147 Suppl p 81.
23. Hinckley, K.A , Keen, P.R., Howard, B.R. and Henderson, I W. (1994) The role of nitric oxide precursors and inhibitors in acute equine laminitis. J. Endocrinol. 143, Suppl. p 103.
24. Hinckley, K.A., Fearn, S., Howard, B.R and Henderson, I.W. (1995) Near infrared spectroscopy of pedal haemodynamics and oxygenation in normal and laminitic horses. Equine vet. J. 27, 465-470
25. Hodson, M., Holled, Willis, Robinson, Holden, Empson, Roper, Medcalfe and Shaw, N. (1672) The Gentleman's Jockey and Approved Farrier, Instructing in the Natures. Causes, and Cures of all Diseases incident to Horses, 2nd edn. Henry Twyford, London, pp 182-185, 292-293.
26. Hood, D M. (1979) Current concepts of the physiopathology of laminitis. Proc. Am. Ass. equine Practnrs 25, 13-20
27. Hood, D.M. (1995) Mechanisms of developmental and acute laminitis British Equine Veterinary Association Day Meeting, Bristol.
28. Hood, D M , Grosenbaugh, D.A., Mostafa, M.B., Morgan, S.J. and Thomas, B.C. (1993) The role of vascular mechanisms in the development of acute laminitis. J vet Intern. Med. 7, 228-234
29. Hood, D.M., Amoss, M.S., Hightower, D, McDonald, D.R., McGrath, J.P., McMullan, W.C. and Scritchfield, W.L (1978) Equine laminitis 1 Radioisotopic analysis of the hemodynamics of the foot during the acute disease. J. equine Med. Surg. 2, 439-444.
30. Hunt, R.J (1991) The pathophysiology of acute laminitis. Comp cont. Educ. pract. vet. 13, 401-407.
31. Katsuki, S., Arnold, W., Mittal, C. and Murad, F. (1977) Stimulation of guanylate cyclase by sodium nitroprusside, nitroglycerine and nitric oxide in various tissue preparations and comparison to the effects of sodium azide and hydroxylarnine J. Cyclic Nucleotide Res 3, 23-35
32. Lees, C., Campbell, S., Jaumaux, E , Brown, R , Ramsay, B., Gibb, D, Moncada, S. and Martin, J F. (1994) Arrest of preterm labour and prolongation of gestation with glycerol trinitrate, a nitric oxide donor. Lancet 343, 1325-1326.
33. Miller, W.G. (1981) Acute Equine Laminitis. Renal Morphology and Endocrine Interplay PhD Thesis, Texas A & M University, USA.
34. Molyneux, G S., Haller, C.J., Mogg, K. and Pollitt, CC (1994) The structure, innervation and location of arteriovenous anastomoses in the equine foot Equine vet J. 26, 305-313.
35. Moncada, S., Palmer, R M J. and Higgs, E A (1991) Nitric oxide physiology, pathophysiology and pharmacology Pharm. Rev. 43, 109-142.
36. Nakaki, T., Hisikawa, K, Suzuki, H., Saruta, T and Kato, R. (1992) L-arginine induced changes in haemodynamics in man. In Biology of Nitric Oxide 1. Physiological and Clinical Aspects Eds S Moncada, M A Marietta, J.B. Hibbs and E.A Higgs. Portland Press, London pp 351-352
37. Obel, N. (1948) Studies on the Histopathology of Acute Laminitis. Almquist and Wiksells Boktryckeri AB, Uppsala, Sweden
38. Palmer, R.M.J , Ferridge, A.G. and Moncada, S. (1987) Nitric oxide accounts for the biological activity of endothelium derived relaxing factor. Nature 327, 524-526.
39. Palmer, R.M.J., Ashton, D.S. and Moncada, S. (1988) Vascular endothelial cells synthesise nitric oxide from L-arginine. Nature 333, 664-666
40. Pollitt, C.C. (1990) A scanning electron microscopical study of the dermal circulation of the equine foot. Equine vet. J. 22, 79-87
41. Rabinowitz, D., Merimee, T.J., Nelson, J K., Schultz, R.B and Burgess, J.A. (1968) The influence of proteins and amino acids on growth hormone release in man. In. Growth Hormone. Eds: A Pecile and E.E. Muller. Exerpta Medica Found. Intern. Cong. Ser 158, 105-115.
42. Rees, D D., Palmer, R.MJ. and Moncada, S. (1989) Role of endothelium derived nitric oxide in the regulation of blood pressure. Proc Nat. Acad Sci USA. 86, 3375-3378.
43. Roberts, E.D., Ochoa, R. and Haynes, P.P. (1980) Correlation of dermal-epidermal laminar lesions of equine hoof with various disease conditions. Vet. Pathol 17, 656-666
44. Robinson, N.E. (1990) Digital blood flow, arteriovenous anastomoses and laminius Equine vet. J. 22, 381-383.
45. Schneider, D.A , Parks, A.H , Holbrook, T C. and Eades, S.C (1994) A comparison of carbohydrate and black walnut models of acute laminitis: in vitro palmar digital vessel relaxation. In: Proceedings of Colic Symposium Oct 1994. Georgia, USA. p 25.
46. Stashak, TD. (1987) Adams' Lameness in Horses, 4th edn. Lea and Febiger Philadelphia USA. pp 486-489
47. Templeton, C B, Bottoms, G.D., Fessier, J F., Turek, J J and Boon, G.D (1985) Effects of repeated endotoxin injections on prostanoids, haemodynamics, endothelial cells and survival in ponies Circulatory Shock 16, 253-264
48. Thorniley, M , Wickramsinghe, Y. and Rolfe, P. (1988) Near infrared spectroscopy: a new technique for the non-invasive monitoring of tissue and blood oxygenation in vivo Biochem. Soc Transactions 16, 978-982.
49. Vallance, P., Leone, A., Calver, A, Collier, J. and Moncada, S. (1992) Accumulation of an inhibitor of nitric oxide synthesis in chronic renal failure. Lancet 339, 572-575.
50. Vane, J.R., Änggård, E.E. and Botting, R.M (1990) Regulatory functions of the vascular endothelium. New Engl J. Med 323, 27-36.
51. Weiss, D.J., Geor, R.J, Johnston, G. and Trent, A.M (1994) Microvascular thrombosis associated with onset of acute laminitis in ponies. Am. J. vet. Res. 55, 606-612