Neuropathogenesis of AIDS

Molecular Medicine Today

Volumn 2, Issue 1, 1996, Pages 16-23

  Dewhurst, Stephen ^a   Gelbard, Harris A ^a   Fine, Steven M ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN IMMUNODEFICIENCY VIRUS 1;

GLUTAMIC ACID; NEUROTOXIN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANIMAL; DEMENTIA; FORECASTING; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; METABOLISM; OXIDATIVE STRESS; PATHOGENICITY; PATHOLOGY; PATHOPHYSIOLOGY; REVIEW;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ANIMALS; DEMENTIA; FORECASTING; GLUTAMIC ACID; HIV-1; HUMANS; NEUROTOXINS; OXIDATIVE STRESS;

EID: 0029687262     PISSN: 13574310     EISSN: None     Source Type: Journal    
DOI: 10.1016/1357-4310(96)88754-5     Document Type: Review

References (39)

1. Bacellar, H. et al. (1994) Temporal trends in the incidence of HIV-1-related neurological diseases: multicenter AIDS cohort study, Neurology 44, 1892-1900
2. Lobato, M.N. et al. (1995) Encephalopathy in children with perinatally acquired human immunodeficiency virus infection, J. Pediatr. 126, 710-715
3. Simpson, D.M. and Tagliati, M. (1994) Neurologic manifestations of HIV infection, Ann. Intern. Med. 121, 769-785
4. Lipton, S.A. and Gendelman, H.E. (1995) Dementia associated with the acquired immunodeficiency syndrome, New Engl. J. Med. 332, 934-940
5. Janssen, R.S. et al. (1991) Nomenclature and research case definitions for neurologic manifestations of human immunodeficiency virus type-1 (HIV-1) infection. Report of a working group of the American Academy of Neurology AIDS Task Force, Neurology 41, 773-785
6. Budka, H. et al. (1991) HIV-associated disease of the nervous system: review of nomenclature and proposal for neuropathology-based terminology, Brain Pathol. 1, 143-152
7. Everall, I.P., Luthert, P.J. and Lantos, P. (1991) Neuronal loss in frontal cortex in HIV infection, Lancet 337, 1119-1121
8. Adle-Biassett, H. et al. (1995) Neuronal apoptosis in HIV infection in adults, Neuropathol. Appl. Neurobiol. 21, 218-227
9. Gelbard, H.A. et al. (1995) Apoptotic neurons in brains from paediatric patients with HIV-1 encephalitis and progressive encephalopathy, Neuropathol. Appl. Neurobiol. 21, 208-217
10. Petito, C.K. and Roberts, B. (1995) Evidence of apoptotic cell death in HIV encephalitis, Am. J. Pathol. 146, 1121-1130
11. Everall, I.P. et al. (1994) Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia, Acta Neuropathol. 88, 538-544
12. Wiley, C.A. and Achim, C. (1994) Human immunodeficiency virus encephalitis is the pathological correlate of dementia in acquired immunodeficiency syndrome, Ann. Neurol. 36, 673-676
13. Blumberg, B.M., Gelbard, H.A. and Epstein, L.G. (1994) HIV-1 infection of the developing nervous system: central role of astrocytes in pathogenesis, Virus Res. 32, 253-267
14. Toggas, S.M. et al. (1994) Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice, Nature 367, 188-193
15. Koka, P. et al. (1995) Human immunodeficiency virus 1 envelope proteins induce interleukin 1, tumor necrosis factor α, and nitric oxide in glial cultures derived from fetal, neonatal, and adult human brain, J. Exp. Med. 182, 941-952
16. Benos, D.J. et al. (1994) Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex, Proc. Natl Acad. Sci. USA 91, 494-498
17. Philippon, V. et al. (1994) The basic domain of the lentiviral Tat protein is responsible for damages in mouse brain: involvement of cytokines, Virology 205, 519-529
18. Magnuson, D.S.K, et al. (1995) Human immunodeficiency virus type 1 Tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity, Ann. Neurol. 37, 373-380
19. Wesselingh, S.L. et al. (1993) Intracerebral cytokine messenger RNA expression in acquired immunodeficiency syndrome dementia, Ann. Neurol. 33, 576-582
20. Gelbard, H.A. et al. (1993) Neurotoxic effects of tumor necrosis factor in primary human neuronal cultures are mediated by activation of the glutamate AMPA receptor subtype: implications for AIDS neuropathogenesis, Dev. Neurosci. 15, 417-422
21. Talley, A.K. et al. (1995) Tumor necrosis factor α induces apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA, Mol. Cell. Biol. 15, 2359-2366
22. Roulston, A. et al. (1995) Regulation of human immunodeficiency virus type 1 and cytokine gene expression in myeloid cells by NF-κB/rel transcription factors, Microbiol. Rev. 59, 481-505
23. Yeung, M.C., Pulliam, L. and Lau, A. (1995) The HIV envelope protein gp120 is toxic to human brain-cell cultures through the induction of interleukin-6 and tumor necrosis factor-α, AIDS 9, 137-143
24. Gelbard, H.A. et al. (1994) Platelet activating factor: a candidate HIV-1-induced neurotoxin, J. Virol. 68, 4828-4635
25. Griffin, D.E., Wesselingh, S.L. and McArthur, J.C. (1994) Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia, Ann. Neurol. 35, 592-597
26. Volterra, A., Trotti, D. and Racagni, G. (1994) Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms, Mol. Pharm. 46, 986-992
27. Sardar, A.M., Bell, J.E. and Reynolds, G.P. (1995) Increased concentrations of the neurotoxin 3-hydroxykynurenine in the frontal cortex of HIV-1-positive patients, J. Neurochem. 64, 932-935
28. Piani, D. and Fontana, A. (1994) Involvement of the cystine transport system xc-in the macrophage-induced glutamate-dependent cytotoxicity to neurons, J. Immunol. 152, 3578-3585
29. Morrison, K.E. (1995) Mechanisms in motor neurone disease: clues from genetic studies, Mol. Med. Today 1, 195-201
30. Rothstein, J.D. et al. (1995) Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis, Ann. Neurol. 38, 73-84
31. Schapira, A.H.V. (1995) Oxidative stress in Parkinson's disease, Neuropathol. Appl. Neurobiol. 21, 3-9
32. LaFerla, F.M. et al. (1995) The Alzheimer's Aβ peptide induces neurodegeneration and apoptotic cell death in transgenic mice, Nat. Genet. 9, 21-29
33. Smith, M.A., Sayre, L.M., Monnier, V.M. and Perry, G. (1995) Radical AGEing in Alzheimer's disease, Trends Neurosci. 18, 172-176
34. Cannella, B. and Raine, C.S. (1995) The adhesion molecule and cytokine profile of multiple sclerosis lesions, Ann. Neurol. 37, 424-435
35. Sidtis, J.J. et al. (1993) Zidovudine treatment of the AIDS dementia complex: results of a placebo-controlled trial, Ann. Neurol. 33, 343-349
36. Baldeweg, T. et al. (1995) Long-term zidovudine reduces neurocognitive deficits in HIV-1 infection, AIDS 9, 589-595
37. Nozyce, M. et al. (1994) A 12-month study of the effects of oral zidovudine on neurodevelopmental functioning in a cohort of vertically HIV-infected inner-city children, AIDS 8, 635-639
38. Lindsay, R.M. (1995) Neuron saving schemes, Nature 373, 289-291
39. Milligan, C.E. et al. (1995) Peptide inhibitors of the ICE protease family arrest programmed cell death of motoneurons in vivo and in vitro, Neuron 15, 385-393