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Volumn 35, Issue C, 1996, Pages 79-114

Current and Future Therapeutic Approaches to Hyperlipidemia

Author keywords

[No Author keywords available]

Indexed keywords

ANTILIPEMIC AGENT; HYPOCHOLESTEROLEMIC AGENT;

EID: 0029684071     PISSN: 10543589     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1054-3589(08)60275-6     Document Type: Article
Times cited : (13)

References (125)
  • 1
    • 0025189674 scopus 로고
    • Effect of fish oil on lipoproteins, lecithin: cholesterol acyltransferase, and lipid transfer protein activity in humans
    • Abbey M., Clifton P., Kestin M., Belling B., and Nestel P. Effect of fish oil on lipoproteins, lecithin: cholesterol acyltransferase, and lipid transfer protein activity in humans. Arteriosclerosis 10 (1990) 85-94
    • (1990) Arteriosclerosis , vol.10 , pp. 85-94
    • Abbey, M.1    Clifton, P.2    Kestin, M.3    Belling, B.4    Nestel, P.5
  • 2
    • 0025254464 scopus 로고
    • Effects of gemfibrozil on lipids and haemostasis after myocardial infarction
    • Andersen P., Smith P., Seljeflot I., Brataker S., and Arnesen H. Effects of gemfibrozil on lipids and haemostasis after myocardial infarction. Thromb. Haemost. 63 (1990) 174-177
    • (1990) Thromb. Haemost. , vol.63 , pp. 174-177
    • Andersen, P.1    Smith, P.2    Seljeflot, I.3    Brataker, S.4    Arnesen, H.5
  • 3
    • 0025345666 scopus 로고
    • Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: Implications for the pathophysiology of apoB production
    • Arad Y.-, Ramakrishnan R., and Ginsberg H.N. Lovastatin therapy reduces low density lipoprotein apoB levels in subjects with combined hyperlipidemia by reducing the production of apoB-containing lipoproteins: Implications for the pathophysiology of apoB production. J. Lipid Res. 31 (1990) 567-582
    • (1990) J. Lipid Res. , vol.31 , pp. 567-582
    • Arad Y.-1    Ramakrishnan, R.2    Ginsberg, H.N.3
  • 4
    • 0016655152 scopus 로고
    • Effect of cholestyramine on 1,2-dimethylhydrazine-induced enteric carcinoma in germfree rats
    • Asano T., Pollard M., and Madsen D.C. Effect of cholestyramine on 1,2-dimethylhydrazine-induced enteric carcinoma in germfree rats. Proc. Soc. Exp. Biol. Med. 150 (1975) 780-785
    • (1975) Proc. Soc. Exp. Biol. Med. , vol.150 , pp. 780-785
    • Asano, T.1    Pollard, M.2    Madsen, D.C.3
  • 5
    • 0026754428 scopus 로고
    • Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience)
    • Assmann G., and Schulte H. Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Am. J. Cardiol. 70 (1992) 733-737
    • (1992) Am. J. Cardiol. , vol.70 , pp. 733-737
    • Assmann, G.1    Schulte, H.2
  • 6
    • 0024558773 scopus 로고
    • Plasma triglyceride as a risk factor for coronary heart disease: The epidemiologic evidence and beyond
    • Austin M.A. Plasma triglyceride as a risk factor for coronary heart disease: The epidemiologic evidence and beyond. Am. J. Epidemiol. 129 (1989) 249-259
    • (1989) Am. J. Epidemiol. , vol.129 , pp. 249-259
    • Austin, M.A.1
  • 7
    • 0026065576 scopus 로고
    • Plasma triglyceride and coronary heart disease
    • Austin M.A. Plasma triglyceride and coronary heart disease. Arterioscler. Thromb. 11 (1991) 2-14
    • (1991) Arterioscler. Thromb. , vol.11 , pp. 2-14
    • Austin, M.A.1
  • 9
    • 0019970496 scopus 로고
    • Treatment of homozygous familial hypercholesterolemia with probucol
    • Baker S.G., Joffe B.I., Mendelsohn D., and Seftel H.C. Treatment of homozygous familial hypercholesterolemia with probucol. S. Afr. Med. J. 62 (1982) 7-11
    • (1982) S. Afr. Med. J. , vol.62 , pp. 7-11
    • Baker, S.G.1    Joffe, B.I.2    Mendelsohn, D.3    Seftel, H.C.4
  • 10
    • 0015369932 scopus 로고
    • Plasma lipids and lipoproteins in Greenlandic west coast Eskimos
    • Bang H.O., and Dyerberg J. Plasma lipids and lipoproteins in Greenlandic west coast Eskimos. Acta Med. Scand. 192 (1972) 85-94
    • (1972) Acta Med. Scand. , vol.192 , pp. 85-94
    • Bang, H.O.1    Dyerberg, J.2
  • 11
    • 0015498050 scopus 로고
    • Digitalis intoxication. Treatment with a new steroid-binding resin
    • Bazzano G., and Bazzano G.S. Digitalis intoxication. Treatment with a new steroid-binding resin. JAMA 220 (1972) 828-830
    • (1972) JAMA , vol.220 , pp. 828-830
    • Bazzano, G.1    Bazzano, G.S.2
  • 14
    • 0018184704 scopus 로고
    • Mode of action of the lipid-lowering agents, clofibrate and BM15075, on cholesterol biosynthesis in rat liver
    • Berndt J., Gaumert R., and Still J. Mode of action of the lipid-lowering agents, clofibrate and BM15075, on cholesterol biosynthesis in rat liver. Atherosclerosis 30 (1978) 147-152
    • (1978) Atherosclerosis , vol.30 , pp. 147-152
    • Berndt, J.1    Gaumert, R.2    Still, J.3
  • 15
    • 1842409007 scopus 로고
    • Atorvastatin: A step ahead for HMG-CoA reductase inhibitors
    • [Abstract]
    • Black D. Atorvastatin: A step ahead for HMG-CoA reductase inhibitors. Atherosclerosis 109 (1994) 88-89 [Abstract]
    • (1994) Atherosclerosis , vol.109 , pp. 88-89
    • Black, D.1
  • 16
    • 84948007950 scopus 로고
    • Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts.
    • Blankenhorn D.H., Nessim S.A., Johnson R.L., Sanmarco M.E., Azen S.P., and Cashin-Hemphill L. Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts. JAMA 257 (1987) 3233-3240
    • (1987) JAMA , vol.257 , pp. 3233-3240
    • Blankenhorn, D.H.1    Nessim, S.A.2    Johnson, R.L.3    Sanmarco, M.E.4    Azen, S.P.5    Cashin-Hemphill, L.6
  • 17
    • 0025055322 scopus 로고
    • Prediction of angiographic change in native human coronary arteries and aortocoronary bypass grafts: Lipid and nonlipid factors
    • Blankenhorn D.H., Alaupovic P., Wickham E., Chin H.P., and Azen S.P. Prediction of angiographic change in native human coronary arteries and aortocoronary bypass grafts: Lipid and nonlipid factors. Circulation 81 (1990) 470-476
    • (1990) Circulation , vol.81 , pp. 470-476
    • Blankenhorn, D.H.1    Alaupovic, P.2    Wickham, E.3    Chin, H.P.4    Azen, S.P.5
  • 19
    • 0025860569 scopus 로고
    • Suppression of eicosanoid biosynthesis during coronary angioplasty by fish oil and aspirin
    • Braden G.A., Knapp H.R., and FitzGerald G.A. Suppression of eicosanoid biosynthesis during coronary angioplasty by fish oil and aspirin. Circulation 84 (1991) 679-685
    • (1991) Circulation , vol.84 , pp. 679-685
    • Braden, G.A.1    Knapp, H.R.2    FitzGerald, G.A.3
  • 27
    • 0024679488 scopus 로고
    • Probucol: A reappraisal of its pharmacological properties and therapeutic use in hypercholesterolaemia.
    • Buckley M.M.-T., Goa K.L., Price A.H., and Brogden R.N. Probucol: A reappraisal of its pharmacological properties and therapeutic use in hypercholesterolaemia. Drugs 37 (1989) 761-800
    • (1989) Drugs , vol.37 , pp. 761-800
    • Buckley, M.M.-T.1    Goa, K.L.2    Price, A.H.3    Brogden, R.N.4
  • 28
    • 0023001772 scopus 로고
    • Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin.
    • forthe Coronary Drug Project Research Group.
    • Canner P.L., Berge K.G., Wenger N.K., Stamler J., Friedman L., Prineas R.J., Friedewald W., and forthe Coronary Drug Project Research Group. Fifteen year mortality in Coronary Drug Project patients: Long-term benefit with niacin. J. Am. Coll. Cardiol. 8 (1986) 1245-1255
    • (1986) J. Am. Coll. Cardiol. , vol.8 , pp. 1245-1255
    • Canner, P.L.1    Berge, K.G.2    Wenger, N.K.3    Stamler, J.4    Friedman, L.5    Prineas, R.J.6    Friedewald, W.7
  • 29
    • 0013693531 scopus 로고
    • Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: Evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit
    • Carew T.E., Schwenke D.C., and Steinberg D. Antiatherogenic effect of probucol unrelated to its hypocholesterolemic effect: Evidence that antioxidants in vivo can selectively inhibit low density lipoprotein degradation in macrophage-rich fatty streaks and slow the progression of atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Proc. Natl. Acad. Sci. U.S.A. 84 (1987) 7725-7729
    • (1987) Proc. Natl. Acad. Sci. U.S.A. , vol.84 , pp. 7725-7729
    • Carew, T.E.1    Schwenke, D.C.2    Steinberg, D.3
  • 30
    • 0023910325 scopus 로고
    • Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid
    • Carlson L.A., and Rosenhamer G. Reduction of mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by combined treatment with clofibrate and nicotinic acid. Acta Med. Scand. 223 (1988) 405-418
    • (1988) Acta Med. Scand. , vol.223 , pp. 405-418
    • Carlson, L.A.1    Rosenhamer, G.2
  • 31
    • 0024466520 scopus 로고
    • Pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid
    • Carlson L.A., Hamsten A., and Asplund A. Pronounced lowering of serum levels of lipoprotein Lp(a) in hyperlipidaemic subjects treated with nicotinic acid. J. Intern. Med. 226 (1989) 271-276
    • (1989) J. Intern. Med. , vol.226 , pp. 271-276
    • Carlson, L.A.1    Hamsten, A.2    Asplund, A.3
  • 32
  • 33
    • 0027453477 scopus 로고
    • Low density lipoprotein receptors bind and mediate cellular catabolism of normal very low density lipoproteins in vitro.
    • Chappell D.A., Fry G.L., Waknitz M.A., Muhonen L.E., and Pladet M.W. Low density lipoprotein receptors bind and mediate cellular catabolism of normal very low density lipoproteins in vitro. J. Biol. Chem. 268 (1993) 25487-25493
    • (1993) J. Biol. Chem. , vol.268 , pp. 25487-25493
    • Chappell, D.A.1    Fry, G.L.2    Waknitz, M.A.3    Muhonen, L.E.4    Pladet, M.W.5
  • 34
    • 0015251974 scopus 로고
    • Nicotinic acid in the treatment of hypercholesterolemia: A long term study
    • Charman R.C., Matthews L.B., and Braeuler C. Nicotinic acid in the treatment of hypercholesterolemia: A long term study. Angiology 23 (1972) 29-35
    • (1972) Angiology , vol.23 , pp. 29-35
    • Charman, R.C.1    Matthews, L.B.2    Braeuler, C.3
  • 35
    • 0024563653 scopus 로고
    • Lipolytic surface remnants of triglyceride-rich lipoproteins are cytotoxic to macrophages but not in the presence of high density lipoprotein: A possible mechanism of atherogenesis?
    • Chung B.H., Segrest J.P., Smith K., Griffin F.M., and Brouillette C.G. Lipolytic surface remnants of triglyceride-rich lipoproteins are cytotoxic to macrophages but not in the presence of high density lipoprotein: A possible mechanism of atherogenesis?. J. Clin. Invest. 83 (1989) 1363-1374
    • (1989) J. Clin. Invest. , vol.83 , pp. 1363-1374
    • Chung, B.H.1    Segrest, J.P.2    Smith, K.3    Griffin, F.M.4    Brouillette, C.G.5
  • 36
    • 0018117095 scopus 로고
    • A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate
    • Committee of Principal Investigators.
    • Committee of Principal Investigators. A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Br. Heart J. 40 (1978) 1069-1118
    • (1978) Br. Heart J. , vol.40 , pp. 1069-1118
  • 37
    • 84920245150 scopus 로고
    • WHO cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: Final mortality follow-up
    • Committee of Principal Investigators.
    • Committee of Principal Investigators. WHO cooperative trial on primary prevention of ischaemic heart disease with clofibrate to lower serum cholesterol: Final mortality follow-up. Lancet 2 (1984) 600-604
    • (1984) Lancet , vol.2 , pp. 600-604
  • 38
    • 0017662977 scopus 로고
    • Increased activity of vitamin K-dependent clotting factors in human hyperlipoproteinaemia-association with cholesterol and triglyceride levels
    • Constantino M., Merskey C., Kudzma D.J., and Zucker M.B. Increased activity of vitamin K-dependent clotting factors in human hyperlipoproteinaemia-association with cholesterol and triglyceride levels. Thromb. Haemost. 38 (1977) 465-474
    • (1977) Thromb. Haemost. , vol.38 , pp. 465-474
    • Constantino, M.1    Merskey, C.2    Kudzma, D.J.3    Zucker, M.B.4
  • 39
    • 0016630250 scopus 로고
    • Clofibrate and niacin in coronary heart disease
    • Coronary Drug Project Research Group.
    • Coronary Drug Project Research Group. Clofibrate and niacin in coronary heart disease. JAMA 231 (1975) 360-381
    • (1975) JAMA , vol.231 , pp. 360-381
  • 40
    • 0023929374 scopus 로고
    • Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients
    • Corpier C.L., Jones P.H., Suki W.N., Lederer E.D., Quinones M.A., Schmidt S.W., and Young J.B. Rhabdomyolysis and renal injury with lovastatin use. Report of two cases in cardiac transplant recipients. JAMA 260 (1988) 239-241
    • (1988) JAMA , vol.260 , pp. 239-241
    • Corpier, C.L.1    Jones, P.H.2    Suki, W.N.3    Lederer, E.D.4    Quinones, M.A.5    Schmidt, S.W.6    Young, J.B.7
  • 41
    • 0024352571 scopus 로고
    • Levels of three hemostatic factors in relation to serum lipids. Monocyte procoagulant activity, tissue plasminogen activator, and type-1 plasminogen activator inhibitor
    • Crutchley D.J., McPhee G.V., Terris M.F., and Canossa-Terris M.A. Levels of three hemostatic factors in relation to serum lipids. Monocyte procoagulant activity, tissue plasminogen activator, and type-1 plasminogen activator inhibitor. Arteriosclerosis 9 (1989) 934-939
    • (1989) Arteriosclerosis , vol.9 , pp. 934-939
    • Crutchley, D.J.1    McPhee, G.V.2    Terris, M.F.3    Canossa-Terris, M.A.4
  • 42
    • 0022342174 scopus 로고
    • The hypolipidemic action of probucol: Drug transport and lipoprotein composition in type Ha hyperlipoproteinemia
    • Dachet C., Jacotot B., and Buxtorf J.C. The hypolipidemic action of probucol: Drug transport and lipoprotein composition in type Ha hyperlipoproteinemia. Atherosclerosis 58 (1985) 261-268
    • (1985) Atherosclerosis , vol.58 , pp. 261-268
    • Dachet, C.1    Jacotot, B.2    Buxtorf, J.C.3
  • 43
    • 0000328589 scopus 로고
    • Fibrates: Areview of important issues and recent findings
    • Davignon J. Fibrates: Areview of important issues and recent findings. Can. J. Cardiol. 10 Suppl B (1994) 61B-71B
    • (1994) Can. J. Cardiol. , vol.10 , Issue.SUPPL. B
    • Davignon, J.1
  • 44
    • 0026643804 scopus 로고
    • Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial
    • Dolecek T.A. Epidemiological evidence of relationships between dietary polyunsaturated fatty acids and mortality in the Multiple Risk Factor Intervention Trial. Proc. Soc. Exp. Biol. Med. 200 (1992) 177-182
    • (1992) Proc. Soc. Exp. Biol. Med. , vol.200 , pp. 177-182
    • Dolecek, T.A.1
  • 46
    • 0021182418 scopus 로고
    • Abnormalities in very low, low, and high density lipoproteins in hypertriglyceridemia: Reversal toward normal with bezafibrate treatment
    • Eisenberg S., Gavish D., Oschry Y., Fainaru M., and Deckelbaum R.J. Abnormalities in very low, low, and high density lipoproteins in hypertriglyceridemia: Reversal toward normal with bezafibrate treatment. J. Clin. Invest. 74 (1984) 470-482
    • (1984) J. Clin. Invest. , vol.74 , pp. 470-482
    • Eisenberg, S.1    Gavish, D.2    Oschry, Y.3    Fainaru, M.4    Deckelbaum, R.J.5
  • 47
    • 0017055252 scopus 로고
    • ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinum.
    • Endo A., Kuroda M., and Tsujita Y. ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogenesis produced by Penicillium citrinum. J. Antibiot. (Tokyo) 29 (1976) 1346-1348
    • (1976) J. Antibiot. (Tokyo) , vol.29 , pp. 1346-1348
    • Endo, A.1    Kuroda, M.2    Tsujita, Y.3
  • 48
    • 0025170519 scopus 로고
    • Effects of probucol on plasma lipids and lipoproteins in familial hypercholesterolemic patients with and without apolipoprotein E4
    • Eto M., Sato T., Watanabe K., Iwashima Y., and Makino I. Effects of probucol on plasma lipids and lipoproteins in familial hypercholesterolemic patients with and without apolipoprotein E4. Atherosclerosis 84 (1990) 49-53
    • (1990) Atherosclerosis , vol.84 , pp. 49-53
    • Eto, M.1    Sato, T.2    Watanabe, K.3    Iwashima, Y.4    Makino, I.5
  • 49
    • 0025070146 scopus 로고
    • Apparent reduced absorption of gemfibrozil when given with colestipol
    • Forland S.C., Feng Y., and Cutler R.E. Apparent reduced absorption of gemfibrozil when given with colestipol. J. Clin. Pharmacol. 30 (1990) 29-32
    • (1990) J. Clin. Pharmacol. , vol.30 , pp. 29-32
    • Forland, S.C.1    Feng, Y.2    Cutler, R.E.3
  • 50
    • 0022412123 scopus 로고
    • Reversible increase of the apo Cll/apo CIII-1 ratio in the very low density lipoproteins after procetofen treatment in hypertriglyceridemic patients
    • Franceschini G., Sirtori M., Gianfranceschi G., Frosi T., Montanari G., and Sirtori C.R. Reversible increase of the apo Cll/apo CIII-1 ratio in the very low density lipoproteins after procetofen treatment in hypertriglyceridemic patients. Artery 12 (1985) 363-381
    • (1985) Artery , vol.12 , pp. 363-381
    • Franceschini, G.1    Sirtori, M.2    Gianfranceschi, G.3    Frosi, T.4    Montanari, G.5    Sirtori, C.R.6
  • 54
    • 0015853466 scopus 로고
    • Nicotinic acid maculopathy
    • Gass J.D. Nicotinic acid maculopathy. Am. J. Ophthalmol. 76 (1973) 500-510
    • (1973) Am. J. Ophthalmol. , vol.76 , pp. 500-510
    • Gass, J.D.1
  • 55
    • 0027457353 scopus 로고
    • Effects of lovastatin on the levels, structure, and atherogenicity of VLDL in patients with moderate hypertriglyceridemia
    • Gianturco S.H., Bradley W.A., Nozaki S., Vega G.L., and Grundy S.M. Effects of lovastatin on the levels, structure, and atherogenicity of VLDL in patients with moderate hypertriglyceridemia. Arterioscler. Thromb. 13 (1993) 472-481
    • (1993) Arterioscler. Thromb. , vol.13 , pp. 472-481
    • Gianturco, S.H.1    Bradley, W.A.2    Nozaki, S.3    Vega, G.L.4    Grundy, S.M.5
  • 57
    • 0026636425 scopus 로고
    • Gemfibrozil-lovastatin therapy for primary hyperlipoproteinemias
    • Glueck C.J., Oakes N., Speirs J., Tracy T., and Lang J. Gemfibrozil-lovastatin therapy for primary hyperlipoproteinemias. Am. J. Cardiol. 70 (1992) 1-9
    • (1992) Am. J. Cardiol. , vol.70 , pp. 1-9
    • Glueck, C.J.1    Oakes, N.2    Speirs, J.3    Tracy, T.4    Lang, J.5
  • 58
    • 0017384270 scopus 로고
    • High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study
    • Gordon T., Castelli W.P., Hjortland M.C., Kannel W.B., and Dawber T.R. High density lipoprotein as a protective factor against coronary heart disease. The Framingham Study. Am. J. Med. 62 (1977) 707-714
    • (1977) Am. J. Med. , vol.62 , pp. 707-714
    • Gordon, T.1    Castelli, W.P.2    Hjortland, M.C.3    Kannel, W.B.4    Dawber, T.R.5
  • 59
    • 0028453509 scopus 로고
    • Postmenopausal hormone-replacement therapy, plasma lipoprotein [a], and risk for coronary heart disease [editorial]
    • Gotto Jr. A.M. Postmenopausal hormone-replacement therapy, plasma lipoprotein [a], and risk for coronary heart disease [editorial]. J. Lab. Clin. Med. 123 (1994) 800
    • (1994) J. Lab. Clin. Med. , vol.123 , pp. 800
    • Gotto Jr., A.M.1
  • 60
    • 0026495295 scopus 로고
    • Effects of estrogen replacement on plasma lipoproteins and apolipoproteins in postmenopausal, dyslipidemic women
    • Granfone A., Campos H., McNamara J.R., Schaefer M.M., Lamon-Fava S., Ordovas J.M., and Schaefer E.J. Effects of estrogen replacement on plasma lipoproteins and apolipoproteins in postmenopausal, dyslipidemic women. Metabolism 41 (1992) 1193-1198
    • (1992) Metabolism , vol.41 , pp. 1193-1198
    • Granfone, A.1    Campos, H.2    McNamara, J.R.3    Schaefer, M.M.4    Lamon-Fava, S.5    Ordovas, J.M.6    Schaefer, E.J.7
  • 62
    • 0006307875 scopus 로고
    • HMG CoA reductase inhibitors: Clinical applications and therapeutic potential.
    • Rifkind B.M. (Ed)
    • Grundy S.M. HMG CoA reductase inhibitors: Clinical applications and therapeutic potential. In: Rifkind B.M. (Ed). "Drug Treatment of Hyperlipidemia" (1991) 139-167
    • (1991) "Drug Treatment of Hyperlipidemia" , pp. 139-167
    • Grundy, S.M.1
  • 63
    • 0021172539 scopus 로고
    • Effects of cholestyramine and colestipol on the plasma concentrations of propranolol
    • Hibbard D.M., Peters J.R., and Hunninghake D.B. Effects of cholestyramine and colestipol on the plasma concentrations of propranolol. Br. J. Clin. Pharmacol. 18 (1984) 337-342
    • (1984) Br. J. Clin. Pharmacol. , vol.18 , pp. 337-342
    • Hibbard, D.M.1    Peters, J.R.2    Hunninghake, D.B.3
  • 64
    • 0025900025 scopus 로고
    • Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells
    • Hidaka Y., Hotta H., Nagata Y., Iwasawa Y., Horie M., and Kamei T. Effect of a novel squalene epoxidase inhibitor, NB-598, on the regulation of cholesterol metabolism in Hep G2 cells. J. Biol. Chem. 266 (1991) 13171-13177
    • (1991) J. Biol. Chem. , vol.266 , pp. 13171-13177
    • Hidaka, Y.1    Hotta, H.2    Nagata, Y.3    Iwasawa, Y.4    Horie, M.5    Kamei, T.6
  • 65
    • 0020120646 scopus 로고
    • The effect of cholestyramine and colestipol on the absorption of hydrochlorothiazide
    • Hunninghake D.B., King S., and LaCroix K. The effect of cholestyramine and colestipol on the absorption of hydrochlorothiazide. Int. J. Clin. Pharmacol. Ther. Toxicol. 20 (1982) 151-154
    • (1982) Int. J. Clin. Pharmacol. Ther. Toxicol. , vol.20 , pp. 151-154
    • Hunninghake, D.B.1    King, S.2    LaCroix, K.3
  • 67
    • 0011272590 scopus 로고
    • Fibric acid derivatives.
    • Rifkind B.M. (Ed), Marcel Dekker, New York.
    • Illingworth D.R. Fibric acid derivatives. In: Rifkind B.M. (Ed). "Drug Treatment of Hyperlipidemia" (1991), Marcel Dekker, New York. 103-138
    • (1991) "Drug Treatment of Hyperlipidemia" , pp. 103-138
    • Illingworth, D.R.1
  • 68
    • 0028096810 scopus 로고
    • A review of clinical trials comparing HMG-CoA reductase inhibitors
    • Illingworth D.R., and Tobert J.A. A review of clinical trials comparing HMG-CoA reductase inhibitors. Clin. Ther. 16 (1994) 366-385
    • (1994) Clin. Ther. , vol.16 , pp. 366-385
    • Illingworth, D.R.1    Tobert, J.A.2
  • 70
    • 0023189234 scopus 로고
    • Metabolic risk factors for coronary heart disease in women: Perspective from the Framingham Study
    • Kannel W.B. Metabolic risk factors for coronary heart disease in women: Perspective from the Framingham Study. Am. Heart J. 114 (1987) 413-419
    • (1987) Am. Heart J. , vol.114 , pp. 413-419
    • Kannel, W.B.1
  • 71
    • 0025152124 scopus 로고
    • Renal vasoconstriction caused by short-term cholesterol feeding is corrected by thromboxane antagonist or probucol
    • Kaplan R., Aynedjian H.S., Schlondorff D., and Bank N. Renal vasoconstriction caused by short-term cholesterol feeding is corrected by thromboxane antagonist or probucol. J. Clin. Invest. 86 (1990) 1707-1714
    • (1990) J. Clin. Invest. , vol.86 , pp. 1707-1714
    • Kaplan, R.1    Aynedjian, H.S.2    Schlondorff, D.3    Bank, N.4
  • 72
    • 0021162405 scopus 로고
    • Influence of probucol on cholesterol and lipoprotein metabolism in man
    • Kesäniemi Y.A., and Grundy S.M. Influence of probucol on cholesterol and lipoprotein metabolism in man. J. Lipid Res. 25 (1984) 780-790
    • (1984) J. Lipid Res. , vol.25 , pp. 780-790
    • Kesäniemi, Y.A.1    Grundy, S.M.2
  • 73
    • 0014173250 scopus 로고
    • Cataracts produced by triparanol
    • Kirby T.J. Cataracts produced by triparanol. Trans. Am. Ophthalmol. Soc. 65 (1967) 493-543
    • (1967) Trans. Am. Ophthalmol. Soc. , vol.65 , pp. 493-543
    • Kirby, T.J.1
  • 75
    • 0028234357 scopus 로고
    • In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses.
    • Kozarsky K.F., McKinley D.R., Austin L.L., Raper S.E., Stratford-Perricaudet L.D., and Wilson J.M. In vivo correction of low density lipoprotein receptor deficiency in the Watanabe heritable hyperlipidemic rabbit with recombinant adenoviruses. J. Biol. Chem. 269 (1994) 13695-13702
    • (1994) J. Biol. Chem. , vol.269 , pp. 13695-13702
    • Kozarsky, K.F.1    McKinley, D.R.2    Austin, L.L.3    Raper, S.E.4    Stratford-Perricaudet, L.D.5    Wilson, J.M.6
  • 76
    • 0028179080 scopus 로고
    • ACAT inhibition decreases LDL cholesterol in rabbits fed a cholesterolfree diet: Marked changes in LDL cholesterol without changes in LDL receptor mRNA abundance
    • Krause B.R., Pape M.E., Kieft K., Auerbach B., Bisgaier C.L., Homan R., and Newton R.S. ACAT inhibition decreases LDL cholesterol in rabbits fed a cholesterolfree diet: Marked changes in LDL cholesterol without changes in LDL receptor mRNA abundance. Arterioscler. Thromb. 14 (1994) 598-604
    • (1994) Arterioscler. Thromb. , vol.14 , pp. 598-604
    • Krause, B.R.1    Pape, M.E.2    Kieft, K.3    Auerbach, B.4    Bisgaier, C.L.5    Homan, R.6    Newton, R.S.7
  • 77
    • 0014421612 scopus 로고
    • Acute muscular syndrome associated with administration of clofibrate. N
    • Langer T., and Levy R.I. Acute muscular syndrome associated with administration of clofibrate. N. Engl. J. Med. 279 (1968) 856-858
    • (1968) Engl. J. Med. , vol.279 , pp. 856-858
    • Langer, T.1    Levy, R.I.2
  • 78
    • 0026043887 scopus 로고
    • Dietary fish oil blocks the microcirculatory manifestations of ischemia-reperfusion injury in striated muscle in hamsters
    • Lehr H.A., Hubner C., Nolte D., Kohlschutter A., and Messmer K. Dietary fish oil blocks the microcirculatory manifestations of ischemia-reperfusion injury in striated muscle in hamsters. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 6726-6730
    • (1991) Proc. Natl. Acad. Sci. U.S.A. , vol.88 , pp. 6726-6730
    • Lehr, H.A.1    Hubner, C.2    Nolte, D.3    Kohlschutter, A.4    Messmer, K.5
  • 79
    • 0027407198 scopus 로고
    • In vivo gene transfer and expression in normal uninjured blood vessels using replication-deficient recombinant adenovirus vectors.
    • Lemarchand P., Jones M., Yamada I., and Crystal R.G. In vivo gene transfer and expression in normal uninjured blood vessels using replication-deficient recombinant adenovirus vectors. Circ. Res. 72 (1993) 1132-1138
    • (1993) Circ. Res. , vol.72 , pp. 1132-1138
    • Lemarchand, P.1    Jones, M.2    Yamada, I.3    Crystal, R.G.4
  • 82
    • 0021350001 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease.
    • Lipid Research Clinics Program
    • Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial results. I. Reduction in incidence of coronary heart disease. JAMA 251 (1984) 351-364
    • (1984) JAMA , vol.251 , pp. 351-364
  • 83
    • 0021349709 scopus 로고
    • The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering.
    • Lipid Research Clinics Program
    • Lipid Research Clinics Program. The Lipid Research Clinics Coronary Primary Prevention Trial results. II. The relationship of reduction in incidence of coronary heart disease to cholesterol lowering. JAMA 251 (1984) 365-374
    • (1984) JAMA , vol.251 , pp. 365-374
  • 84
    • 0024605599 scopus 로고
    • Nicotinic acid-associated myopathy: A report of three cases
    • Litin S.C., and Anderson C.F. Nicotinic acid-associated myopathy: A report of three cases. Am. J. Med. 86 (1989) 481-483
    • (1989) Am. J. Med. , vol.86 , pp. 481-483
    • Litin, S.C.1    Anderson, C.F.2
  • 85
    • 0025148799 scopus 로고
    • Lipoprotein(a): A unique risk factor for atherothrombotic disease
    • Loscalzo J. Lipoprotein(a): A unique risk factor for atherothrombotic disease. Arteriosclerosis 10 (1990) 672-679
    • (1990) Arteriosclerosis , vol.10 , pp. 672-679
    • Loscalzo, J.1
  • 86
    • 0027981582 scopus 로고
    • Effect of simvastatin on coronary atheroma: The Multicentre Anti-Atheroma Study (MAAS).
    • MAAS Investigators
    • MAAS Investigators. Effect of simvastatin on coronary atheroma: The Multicentre Anti-Atheroma Study (MAAS). Lancet 344 (1994) 633-638
    • (1994) Lancet , vol.344 , pp. 633-638
  • 87
    • 0026597808 scopus 로고
    • Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study: Implications for treatment
    • Manninen V., Tenkanen L., Koskinen P., Huttunen J.K., Mänttäri M., Heinonen O.P., and Frick M.H. Joint effects of serum triglyceride and LDL cholesterol and HDL cholesterol concentrations on coronary heart disease risk in the Helsinki Heart Study: Implications for treatment. Circulation 85 (1992) 37-45
    • (1992) Circulation , vol.85 , pp. 37-45
    • Manninen, V.1    Tenkanen, L.2    Koskinen, P.3    Huttunen, J.K.4    Mänttäri, M.5    Heinonen, O.P.6    Frick, M.H.7
  • 89
  • 90
    • 0027284492 scopus 로고
    • Does fish oil lower blood pressure? A meta-analysis of controlled trials
    • Morris M.C., Sacks F., and Rosner B. Does fish oil lower blood pressure? A meta-analysis of controlled trials. Circulation 88 (1993) 523-533
    • (1993) Circulation , vol.88 , pp. 523-533
    • Morris, M.C.1    Sacks, F.2    Rosner, B.3
  • 91
    • 0024403418 scopus 로고
    • Fulminant hepatic failure after ingestion of sustained-release nicotinic acid
    • Mullin G.E., Greenson J.K., and Mitchell M.C. Fulminant hepatic failure after ingestion of sustained-release nicotinic acid. Ann. Intern. Med. 111 (1989) 253-255
    • (1989) Ann. Intern. Med. , vol.111 , pp. 253-255
    • Mullin, G.E.1    Greenson, J.K.2    Mitchell, M.C.3
  • 92
    • 0028154543 scopus 로고
    • Second report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II)
    • National Cholesterol Education Program.
    • National Cholesterol Education Program. Second report of the Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). Circulation 89 (1994) 1329-1445
    • (1994) Circulation , vol.89 , pp. 1329-1445
  • 93
    • 0021278243 scopus 로고
    • Suppression by diets rich in fish oil of very low density lipoprotein production in man
    • Nestel P.J., Connor W.E., Reardon M.F., Connor S., Wong S., and Boston R. Suppression by diets rich in fish oil of very low density lipoprotein production in man. J. Clin. Invest. 74 (1984) 82-89
    • (1984) J. Clin. Invest. , vol.74 , pp. 82-89
    • Nestel, P.J.1    Connor, W.E.2    Reardon, M.F.3    Connor, S.4    Wong, S.5    Boston, R.6
  • 94
    • 0027399112 scopus 로고
    • Atherosclerosis in Alaska Natives and non-natives
    • Newman W.P., Middaugh J.P., Propst M.T., and Rogers D.R. Atherosclerosis in Alaska Natives and non-natives. Lancet 341 (1993) 1056-1057
    • (1993) Lancet , vol.341 , pp. 1056-1057
    • Newman, W.P.1    Middaugh, J.P.2    Propst, M.T.3    Rogers, D.R.4
  • 95
    • 0017346450 scopus 로고
    • Effect of clofibrate on postheparin plasma triglyceride lipase activities in patients with hypertriglyceridemia
    • Nikkila E.A., Huttunen J.K., and Ehnholm C. Effect of clofibrate on postheparin plasma triglyceride lipase activities in patients with hypertriglyceridemia. Metabolism 26 (1977) 179-186
    • (1977) Metabolism , vol.26 , pp. 179-186
    • Nikkila, E.A.1    Huttunen, J.K.2    Ehnholm, C.3
  • 97
    • 0025365041 scopus 로고
    • Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy
    • Pierce L.R., Wysowski D.K., and Gross T.P. Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy. JAMA 264 (1990) 71-75
    • (1990) JAMA , vol.264 , pp. 71-75
    • Pierce, L.R.1    Wysowski, D.K.2    Gross, T.P.3
  • 98
    • 0028849703 scopus 로고
    • Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC I) reduction in atherosclerosis progression and clinical events
    • for the PLACI Investigators.
    • Pitt B., Mancini G.B.J., Ellis S.G., Rosman H.S., Park J.-S., McGovern M.E., and for the PLACI Investigators. Pravastatin Limitation of Atherosclerosis in the Coronary Arteries (PLAC I) reduction in atherosclerosis progression and clinical events. J. Am. Coll. Cardiol. 26 (1995) 1133-1139
    • (1995) J. Am. Coll. Cardiol. , vol.26 , pp. 1133-1139
    • Pitt, B.1    Mancini, G.B.J.2    Ellis, S.G.3    Rosman, H.S.4    Park, J.-S.5    McGovern, M.E.6
  • 99
    • 0026509811 scopus 로고
    • Hepatic toxicity of unmodified and time-release preparations of niacin
    • Rader J.I., Calvert R.J., and Hathcock J.N. Hepatic toxicity of unmodified and time-release preparations of niacin. Am. J. Med. 92 (1992) 77-81
    • (1992) Am. J. Med. , vol.92 , pp. 77-81
    • Rader, J.I.1    Calvert, R.J.2    Hathcock, J.N.3
  • 100
    • 0023750428 scopus 로고
    • Lovastatin, nicotinic acid, and rhabdomyolysis [letter]
    • Reaven P., and Witztum J.L. Lovastatin, nicotinic acid, and rhabdomyolysis [letter]. Ann. Intern. Med. 109 (1988) 597-598
    • (1988) Ann. Intern. Med. , vol.109 , pp. 597-598
    • Reaven, P.1    Witztum, J.L.2
  • 101
    • 0027987849 scopus 로고
    • Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S).
    • Scandinavian Simvastatin Survival Study Group.
    • Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: The Scandinavian Simvastatin Survival Study (4S). Lancet 344 (1994) 1383-1389
    • (1994) Lancet , vol.344 , pp. 1383-1389
  • 103
    • 0018743112 scopus 로고
    • Effects of nicotinic acid therapy on plasma high density lipoprotein subfraction distribution and composition and on apolipoprotein A metabolism
    • Shepherd J., Packard C.J., Patsch J.R., Gotto Jr. A.M., and Taunton O.D. Effects of nicotinic acid therapy on plasma high density lipoprotein subfraction distribution and composition and on apolipoprotein A metabolism. J. Clin. Invest. 63 (1979) 858-867
    • (1979) J. Clin. Invest. , vol.63 , pp. 858-867
    • Shepherd, J.1    Packard, C.J.2    Patsch, J.R.3    Gotto Jr., A.M.4    Taunton, O.D.5
  • 104
    • 0028883828 scopus 로고
    • Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia
    • for the West of Scotland Coronary Prevention Study Group.
    • Shepherd J., Cobbe S.M., Ford I., Isles C.G., Lorimer A.R., Macfarlene P.W., McKillop J.H., Packard C.J., and for the West of Scotland Coronary Prevention Study Group. Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N. Engl. J. Med. 333 (1995) 1301-1307
    • (1995) N. Engl. J. Med. , vol.333 , pp. 1301-1307
    • Shepherd, J.1    Cobbe, S.M.2    Ford, I.3    Isles, C.G.4    Lorimer, A.R.5    Macfarlene, P.W.6    McKillop, J.H.7    Packard, C.J.8
  • 106
    • 0026494899 scopus 로고
    • Tolerability of fibric acids. Comparative data and biochemical bases
    • Sirtori C.R., Calabresi L., Werba J.P., and Franceschini G. Tolerability of fibric acids. Comparative data and biochemical bases. Pharmacol. Res. 26 (1992) 243-260
    • (1992) Pharmacol. Res. , vol.26 , pp. 243-260
    • Sirtori, C.R.1    Calabresi, L.2    Werba, J.P.3    Franceschini, G.4
  • 107
    • 0025756150 scopus 로고
    • Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents
    • Sliskovic D.R., and White A.D. Therapeutic potential of ACAT inhibitors as lipid lowering and anti-atherosclerotic agents. Trends Pharmacol. Sci. 12 (1991) 194-199
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 194-199
    • Sliskovic, D.R.1    White, A.D.2
  • 109
    • 0026021274 scopus 로고
    • Rhabdomyolysis associated with lovastatin and erythromycin use
    • Spach D.H., Bauwens J.E., Clark C.D., and Burke W.G. Rhabdomyolysis associated with lovastatin and erythromycin use. West J. Med. 154 (1991) 213-216
    • (1991) West J. Med. , vol.154 , pp. 213-216
    • Spach, D.H.1    Bauwens, J.E.2    Clark, C.D.3    Burke, W.G.4
  • 110
    • 0025873036 scopus 로고
    • Low density lipoprotein density and composition in hypercholesterolaemic men treated with HMG CoA reductase inhibitors and gemfibrozil
    • Tilly-Kiesi M., and Tikkanen M.J. Low density lipoprotein density and composition in hypercholesterolaemic men treated with HMG CoA reductase inhibitors and gemfibrozil. J. Intern. Med. 229 (1991) 427-434
    • (1991) J. Intern. Med. , vol.229 , pp. 427-434
    • Tilly-Kiesi, M.1    Tikkanen, M.J.2
  • 111
    • 0023697436 scopus 로고
    • Efficacy and long-term adverse effect pattern of lovastatin
    • Tobert J.A. Efficacy and long-term adverse effect pattern of lovastatin. Am. J. Cardiol. 62 (1988) 28J-34J
    • (1988) Am. J. Cardiol. , vol.62
    • Tobert, J.A.1
  • 113
    • 0023677227 scopus 로고
    • Gemfibrozil: A review of its pharmacodynamic and pharma-cokinetic properties, and therapeutic use in dyslipidaemia
    • Todd P.A., and Ward A. Gemfibrozil: A review of its pharmacodynamic and pharma-cokinetic properties, and therapeutic use in dyslipidaemia. Drugs 36 (1988) 314-339
    • (1988) Drugs , vol.36 , pp. 314-339
    • Todd, P.A.1    Ward, A.2
  • 116
    • 0026693534 scopus 로고
    • Regional differences in arterial low density lipoprotein metabolism in surgically postmenopausal cynomolgus monkeys. Effects of estrogen and progesterone replacement therapy
    • Wagner J.D., St Clair R.W., Schwenke D.C., Shively C.A., Adams M.R., and Clarkson T.B. Regional differences in arterial low density lipoprotein metabolism in surgically postmenopausal cynomolgus monkeys. Effects of estrogen and progesterone replacement therapy. Arterioscler. Thromb. 12 (1992) 717-726
    • (1992) Arterioscler. Thromb. , vol.12 , pp. 717-726
    • Wagner, J.D.1    St Clair, R.W.2    Schwenke, D.C.3    Shively, C.A.4    Adams, M.R.5    Clarkson, T.B.6
  • 119
    • 0028267313 scopus 로고
    • Effects of monotherapy with an HMG-CoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography: The Canadian Coronary Atherosclerosis Intervention Trial
    • the CCATT Study Group.
    • Waters D., Higginson L., Gladstone P., Kimball B., LeMay M., Boccuzzi S.J., Lespérance M., and the CCATT Study Group. Effects of monotherapy with an HMG-CoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography: The Canadian Coronary Atherosclerosis Intervention Trial. Circulation 89 (1994) 959-968
    • (1994) Circulation , vol.89 , pp. 959-968
    • Waters, D.1    Higginson, L.2    Gladstone, P.3    Kimball, B.4    LeMay, M.5    Boccuzzi, S.J.6    Lespérance, M.7
  • 120
    • 0026582213 scopus 로고
    • Effects on coronary artery disease of lipid-lowering diet, or diet plus cholestyramine, in the St Thomas' Atherosclerosis Regression Study (STARS)
    • Watts G.F., Lewis B., Brunt J.N.H., Lewis E.S., Coltart D.J., Smith L.D.R., Mann J.I., and Swan A.V. Effects on coronary artery disease of lipid-lowering diet, or diet plus cholestyramine, in the St Thomas' Atherosclerosis Regression Study (STARS). Lancet 339 (1992) 563-569
    • (1992) Lancet , vol.339 , pp. 563-569
    • Watts, G.F.1    Lewis, B.2    Brunt, J.N.H.3    Lewis, E.S.4    Coltart, D.J.5    Smith, L.D.R.6    Mann, J.I.7    Swan, A.V.8
  • 122
    • 77957126077 scopus 로고
    • Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women: The Postmenopausal Estrogen/ Progestin Interventions (PEPI) trial.
    • Writing Group for the PEPI trial.
    • Writing Group for the PEPI trial. Effects of estrogen or estrogen/progestin regimens on heart disease risk factors in postmenopausal women: The Postmenopausal Estrogen/ Progestin Interventions (PEPI) trial. JAMA 273 (1995) 199-208
    • (1995) JAMA , vol.273 , pp. 199-208
  • 124
    • 0025223108 scopus 로고
    • Putative mechanisms of action of probucol on high-density lipoprotein apolipoprotein A-I and its isoproteins kinetics in rabbits
    • Ying H., Saku K., Harada R., Takami N., Sasaki N., Saito Y., and Arakawa K. Putative mechanisms of action of probucol on high-density lipoprotein apolipoprotein A-I and its isoproteins kinetics in rabbits. Biochim. Biophys. Acta 1047 (1990) 247-254
    • (1990) Biochim. Biophys. Acta , vol.1047 , pp. 247-254
    • Ying, H.1    Saku, K.2    Harada, R.3    Takami, N.4    Sasaki, N.5    Saito, Y.6    Arakawa, K.7
  • 125
    • 0018649439 scopus 로고
    • Atherogenesis: A postprandial phenomenon.
    • Zilversmit D.B. Atherogenesis: A postprandial phenomenon. Circulation: 60 (1979) 473-485
    • (1979) Circulation: , vol.60 , pp. 473-485
    • Zilversmit, D.B.1


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