Preferential virological response to interferon-α(2a) in patients with chronic hepatitis C infected by virus genotype 3a and exhibiting a low γ-GT/ALT ratio

Digestive Diseases and Sciences

Volumn 41, Issue 6, 1996, Pages 1256-1264

  Mihm, Sabine ^a   Hartmann, Heinz ^a   Fayyazi, Afshin ^a   Ramadori, Giuliano ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

Author keywords

Glutamyltransferase; Chronic hepatitis C; Hepatitis C virus; Hepatitis C virus genotype; Interferon

Indexed keywords

ALPHA INTERFERON; GAMMA GLUTAMYLTRANSFERASE; RECOMBINANT ALPHA2A INTERFERON;

ADULT; ARTICLE; CHRONIC HEPATITIS; CONTROLLED STUDY; FEMALE; HEPATITIS C; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ALANINE TRANSAMINASE; CHRONIC DISEASE; FEMALE; GAMMA-GLUTAMYLTRANSFERASE; GENOTYPE; HEPACIVIRUS; HEPATITIS C; HUMANS; INTERFERON ALFA-2A; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; RNA, VIRAL;

EID: 0029682112     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02088246     Document Type: Article

References (30)

1. Choo Q-L, Kuo G, Weiner AJ, Overby LR, Bradley DW, Houghton M: Isolation of cDNA clone derived from a blood-horne non-A, non-B viral hepatitis genome. Science 244:359-362, 1989
2. Simmonds P: Variability of hepatitis C virus. Hepatology 14:570-583, 1995
3. Han JH, Houghton M: Group specific sequences and conserved secondary structures at the 3′ end of HCV genome and its implication for viral replication. NAR 20:3520, 1992
4. Isaacs A, Lindenmann J: Virus interference. I. The interferon. Proc R Soc London Ser B 147:258-267, 1957
5. Sen GC, Ransohoff RM: Interferon-indueed antiviral actions and their regulation. Adv Virus Res 42:57-102, 1993
6. Lau JYN, Mizokami M, Ohno T, Diamond DA, Kniffen J, Davis GL: Discrepancy between biochemical and virological responses to interferon-α in chronic hepatitis C. Lancet 342:1208-1209, 1993
7. Pawlotsky J-M, Roudot-Thoraval F, Duvoux C, Dhumeaux D, Babany G: Virological and biochemical responses to interferon-α in chronic hepatitis C. Lancet 343:54-55, 1994
8. Lau JYN, Davis GL, Kniffen J, Qian K-P, Urdea MS, Chan CS, Mizokami M, Neuwald PD, Wilber JC: Significance of serum hepatitis C virus RNA levels in chronic hepatitis C. Lancet 341:1501-1504, 1993
9. Mahaney K, Tedeschi V, Maertens G, Di Bisccglie AM, Vergalla J, Hoofnagle JH, Sallie R: Genotypic analysis of hepatitis C virus in American patients. Hepatology 20:1405-1411, 1994
10. Tsubota A, Chayama K, Ikeda K, Yasuji A, Koida I, Saitoh S, Hashimoto M, Iwasaki S, Kobayashi M, Hiromitsu K: Factors predictive of response to interferon-α therapy in hepatitis C virus infection. Hepatology 19:1088-1094, 1994
11. Mita E, Hayashi N, Hagiwara H, Ucda K, Kanazawa Y, Kasahara A, Fusamoto H, Kamada T: Predicting interferon therapy efficacy from hepatitis C virus genotype and RNA titer. Dig Dis Sci 39:977-982, 1994
12. Yamada G, Takahashi M, Miyamoto R, Tsuji T, Yoshizawa H, Okamoto H: Prediction of interferon effect in chronic hepatitis C by both quantification and genotyping of HCV RNA. Dig Dis Sci 39:441, 1994
13. Kasahara A, Hayashi N, Hiramatsu N, Oshita M, Hagiwara H, Katayama K, Kato M, Masuzawa M, Yoshihara H, Kishida Y, Shimizu Y, Inoue A, Fusamoto H, Kamada T: Ability of prolonged interferon treatment to suppress relapse after cessation of therapy in patients with chronic hepatitis C: A multicenter randomized controlled trial. Hepatology 21:291-297, 1995
14. Hino K, Okuda M, Konishi T, Ishiko H, Okita K: Serial assay of hepatitis C virus RNA in serum for predicting response to interferon-α therapy. Dig Dis Sci 40:14-20, 1995
15. Mazzella G, Salzetta A, Casanova S, Morelli MC, Villanova N, Miniero R, Sottili S, Novelli V, Cipolla A, Festi D, Roda E: Treatment of chronic sporadic-type non-A, non-B hepatitis with lymphoblastoid interferon: gamma GT levels predictive for response. Dig Dis Sci 39:866-870, 1994
16. Pagliaro L, Craxi A, Cammaa C, Tine F, Di Marco V, Iacono OL, Almasio P: Interferon-α for chronic hepatitis C: An analysis of pretreatment clinical predictors of response. Hepatology 19:820-828, 1994
17. Davis GL: Prediction of response to interferon treatment of chronic hepatitis C. J Hepatol 21:1-3, 1994
18. Camps J, Garcia-Granero M, Riezu-Boj JI, Larrea E, de Alava E, Civeira MP, Castilla A, Prieto J: Prediction of sustained remission of chronic hepatitis C after a 12-month course of alfa interferon. J Hepatol 21:4-11, 1994
19. Serfaty L, Giral P, Loria A, Andreani T, Legendre C, Poupon R: Factors predictive of the response to interferon in patients with chronic hepatitis C. J Hepatol 21:12-17, 1994
20. Jouet P, Roudot-Thoraval F, Dhumeaux D, Metreau J-M, le groupe français pour l'étude du traitement des hépatites chroniques NANB/C: Comparative efficacy of interferon alfa in cirrhotic and noncirrhotic patients with non-A, non-B, C hepatitis. Gastroenterology 106:686-690, 1994
21. Desmet VJ, Gerber M, Hoofnagle JH, Manns M, Scheuer PJ: Classification of chronic hepatitis: Diagnosis, grading and staging. Hepatology 19:1513-1520, 1994
22. Okamoto H, Sugiyama Y, Okada S, Kurai K, Akahanc Y, Sugai Y, Tanaka T, Sato K, Tsuda F, Miyakawa Y, Mayumi M: Typing hepatitis C virus by polymerase chain reaction with type-specific primer: Application to clinical surveys and tracing infectious sources. J Gen Virol 73:673-679, 1992
23. Okamoto H, Tokita H, Sakamoto M, Horikita M, Kojima M, Iizuka H, Mishiro S: Characterization of the genomic sequence of type V (or 3a) hepatitis C virus isolates and PCR primer for specific detection. J Gen Virol 74:2385-2390, 1993
24. Simmonds P, McOmish F, Yap PL, Chan S-W, Lin CK, Dusheiko G, Saced AA, Holmes EC: Sequence variability in the 5′ non-coding region of hepatitis C virus: Identification of a new virus type and restrictions on sequence diversity. J Gen Virol 74:661-668, 1993
25. Kwok S, Higuchi R: Avoiding false positives with PCR. Nature 339:237-238, 1989
26. Sarkar G, Sommer SS: Shedding light on PCR contamination. Nature 343:27, 1990
27. Erlich HA, Gelfand D, Sninsky JJ: Recent advances in the polymerase chain reaction. Science 252:1643-1651, 1991
28. Goldberg DM: Structural, functional, and clinical aspects of γ-glutamyltransferase. Crit Rev Clin Lab Sci 12:1-58, 1980
29. Silini E, Bono F, Cividini A, Cerino A, Bruno S, Rossi S, Belloni G, Brugnetti B, Civardi E, Salvancsehi L, Mondelli MU: Differential distribution of hepatitis C virus genotypes in patients with and without liver function abnormalities. Hepatology 21:285-290, 1995
30. Kobayashi Y, Watanabe S, Konishi M, Yokoi M, Kakehashi R, Kaito M, Kondo M, Hayashi Y, Jomori T, Suzuki S: Quantitation and typing of serum hepatitis C virus RNA in patients with chronic hepatitis C treated with interferon-β. Hepatology 18:1319-1325, 1993