Lauramide diethanolamine absorption, metabolism, and disposition in rats and mice after oral, intravenous, and dermal administration

Drug Metabolism and Disposition

Volumn 24, Issue 7, 1996, Pages 702-710

  Mathews, James M ^a   Decosta, Kristi ^a   Thomas, Brian F ^a  

^a RTI INTERNATIONAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 14; COSMETIC; DIETHANOLAMINE; EMOLLIENT AGENT; ISOENZYME; LAURAMIDE DIETHANOLAMINE; PHTHALIC ACID BIS(2 ETHYLHEXYL) ESTER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ABSORPTION; DRUG CLEARANCE; DRUG DISPOSITION; DRUG EXCRETION; DRUG TISSUE LEVEL; DRUG URINE LEVEL; FATTY ACID METABOLISM; HUMAN; HUMAN TISSUE; HYDROXYLATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; TOPICAL DRUG ADMINISTRATION;

ABSORPTION; ADIPOSE TISSUE; ADMINISTRATION, CUTANEOUS; ADMINISTRATION, ORAL; ALKANE 1-MONOOXYGENASE; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DIETHYLHEXYL PHTHALATE; ETHANOLAMINES; HUMANS; INJECTIONS, INTRAVENOUS; KIDNEY; LAURIC ACIDS; LIVER; MALE; MICE; MIXED FUNCTION OXYGENASES; RATS; RATS, INBRED F344;

EID: 0029681467     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (8)

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2. J. Merdink, C. B. Jones, K. deCosta, J. Mathews, J. R. Okita, and R. T. Okita: Hydroxylation of lauramide diethanolamine by liver microsomes. Drug Metab. Dispos. 24, 180-186 (1996).
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6. J. M. Mathews, C. E. Garner, and H. B. Matthews: Metabolism, bioaccumulation and incorporation of diethanolamine into phospholipids. Chem. Res. Toxicol. 8, 625-633 (1995).
7. E. Hollo: Untersuchungen über den Einfluβ des Ring-Sauerstoffatoms auf die Reaktionsgeschwindigkeit gewisser Lactone. Berichte 61, 895-906 (1928).
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