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Volumn 13, Issue 6, 1996, Pages

Drug biotransformation by the cytochrome P-450 enzyme system

Author keywords

Cytochrome P 450; Pharmacology

Indexed keywords

ANTIBIOTIC AGENT; ANTIDEPRESSANT AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARBAMAZEPINE; CARDIOVASCULAR AGENT; CIMETIDINE; CLOMIPRAMINE; CORTICOSTEROID; CYTOCHROME P450; DAPSONE; DEBRISOQUINE; DIAZEPAM; DILTIAZEM; ENALAPRIL; GASTROINTESTINAL AGENT; ISONIAZID; ITRACONAZOLE; KETOCONAZOLE; NIFEDIPINE; NORFLOXACIN; OMEPRAZOLE; PARACETAMOL; PHENYTOIN; PSYCHOTROPIC AGENT; QUINIDINE; SERTRALINE; THEOPHYLLINE; UNINDEXED DRUG; VERAPAMIL; WARFARIN;

EID: 0029680201     PISSN: 07496524     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (11)

References (21)
  • 2
    • 0022534617 scopus 로고
    • Factors affecting drug biotransformation
    • Renton KW: Factors affecting drug biotransformation. Clin Biochem 19:72-75, 1986.
    • (1986) Clin Biochem , vol.19 , pp. 72-75
    • Renton, K.W.1
  • 3
    • 0029131555 scopus 로고
    • Clinical importance of hepatic cytochrome P450 in drug metabolism
    • Spatzenegger M, Jaeger W: Clinical importance of hepatic cytochrome P450 in drug metabolism. Drug Metab Rev 27:397-417, 1995.
    • (1995) Drug Metab Rev , vol.27 , pp. 397-417
    • Spatzenegger, M.1    Jaeger, W.2
  • 4
    • 0026644535 scopus 로고
    • Drug metabolism by cytochromes P450 in the liver and small bowel
    • Watkins PB: Drug metabolism by cytochromes P450 in the liver and small bowel. Gastroenterol Clin North Am 21:511-526, 1992.
    • (1992) Gastroenterol Clin North Am , vol.21 , pp. 511-526
    • Watkins, P.B.1
  • 5
    • 0026750647 scopus 로고
    • The human hepatic cytochrome P450 involved in drug metabolism
    • Wrighton SA, Stevens JC: The human hepatic cytochrome P450 involved in drug metabolism. Crit Rev Toxicol 22:1-21, 1992.
    • (1992) Crit Rev Toxicol , vol.22 , pp. 1-21
    • Wrighton, S.A.1    Stevens, J.C.2
  • 6
    • 0028252257 scopus 로고
    • The impact of genetic polymorphisms in risk assessment of drugs
    • Poulsen HE, Loft S: The impact of genetic polymorphisms in risk assessment of drugs. Arch Toxicol Suppl 16:211-222, 1994.
    • (1994) Arch Toxicol Suppl , vol.16 , pp. 211-222
    • Poulsen, H.E.1    Loft, S.2
  • 7
    • 0027946851 scopus 로고
    • Genetic differences in drug disposition
    • May DG: Genetic differences in drug disposition. J Clin Pharmacol 34:881-897, 1994.
    • (1994) J Clin Pharmacol , vol.34 , pp. 881-897
    • May, D.G.1
  • 8
    • 0004224123 scopus 로고
    • Drug interaction mechanisms and clinical characteristics
    • Vancouver, Washington, Applied Therapeutics
    • Hansten P, Horn J. Drug interaction mechanisms and clinical characteristics, in Drug Interactions and Updates. Vancouver, Washington, Applied Therapeutics, 1993, pp 1-29.
    • (1993) Drug Interactions and Updates , pp. 1-29
    • Hansten, P.1    Horn, J.2
  • 9
    • 0026681168 scopus 로고
    • P450 enzymes. Inhibition mechanisms, genetic regulation, and effects of liver disease
    • Murray M: P450 enzymes. Inhibition mechanisms, genetic regulation, and effects of liver disease. Clin Pharmacokinet 23:132-146, 1992.
    • (1992) Clin Pharmacokinet , vol.23 , pp. 132-146
    • Murray, M.1
  • 10
    • 0022253108 scopus 로고
    • On the mechanism of the inactivation of the major phenobarbital-inducible isoenzyme of rat liver cytochrome P-450 by chloramphenicol
    • Halpert JR, Miller NE, Gorksy LD: On the mechanism of the inactivation of the major phenobarbital-inducible isoenzyme of rat liver cytochrome P-450 by chloramphenicol. J Biol Chem 260:8397-8403, 1985.
    • (1985) J Biol Chem , vol.260 , pp. 8397-8403
    • Halpert, J.R.1    Miller, N.E.2    Gorksy, L.D.3
  • 11
    • 0019509069 scopus 로고
    • Covalent modification of lysine during the suicide inactivation of rat liver cytochrome P-450 by chloramphenicol
    • Halpert J: Covalent modification of lysine during the suicide inactivation of rat liver cytochrome P-450 by chloramphenicol. Biochem Pharmacol 30:875-881, 1981.
    • (1981) Biochem Pharmacol , vol.30 , pp. 875-881
    • Halpert, J.1
  • 12
    • 0027440142 scopus 로고
    • Pharmacokinetic drug interactions with antimicrobial agents
    • Gillum JG, Israel DS, Polk RE: Pharmacokinetic drug interactions with antimicrobial agents. Clin Pharmacokinet 25:450-482, 1993.
    • (1993) Clin Pharmacokinet , vol.25 , pp. 450-482
    • Gillum, J.G.1    Israel, D.S.2    Polk, R.E.3
  • 13
    • 0026565770 scopus 로고
    • Effect of the addition of ciprofloxacin on theophylline pharmacokinetics in subjects inhibited by cimetidine
    • Davis RL, Quenzer RW, Kelly HW, et al: Effect of the addition of ciprofloxacin on theophylline pharmacokinetics in subjects inhibited by cimetidine. Pharmacotherapy 26:11-13, 1992.
    • (1992) Pharmacotherapy , vol.26 , pp. 11-13
    • Davis, R.L.1    Quenzer, R.W.2    Kelly, H.W.3
  • 14
    • 0019415838 scopus 로고
    • Self-induction by erythromycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450
    • Danan G, Descatoire V, Pessayre D: Self-induction by erythromycin of its own transformation into a metabolite forming an inactive complex with reduced cytochrome P-450. J Pharmacol Exp Ther 218:509-514, 1981.
    • (1981) J Pharmacol Exp Ther , vol.218 , pp. 509-514
    • Danan, G.1    Descatoire, V.2    Pessayre, D.3
  • 15
    • 0020460723 scopus 로고
    • Effect of Interferon on hepatic cytochrome P-450 drug metabolizing systems
    • Singh G, Renton KW, Stebbing N: Effect of Interferon on hepatic cytochrome P-450 drug metabolizing systems. Biochem Biophys Res Commun 106:1256-1260, 1982.
    • (1982) Biochem Biophys Res Commun , vol.106 , pp. 1256-1260
    • Singh, G.1    Renton, K.W.2    Stebbing, N.3
  • 16
    • 0018871686 scopus 로고
    • Type II Interferon induction and passive transfer depress the murine cytochrome P-450 drug metabolism system
    • Sonnenfeld G, Harned CL, Thaniyavarn S, et al: Type II Interferon induction and passive transfer depress the murine cytochrome P-450 drug metabolism system. Antimicrob Agents Chemother 17:969-972, 1980.
    • (1980) Antimicrob Agents Chemother , vol.17 , pp. 969-972
    • Sonnenfeld, G.1    Harned, C.L.2    Thaniyavarn, S.3
  • 17
    • 0020454831 scopus 로고
    • Effects of three recombinant human leucocyte interferons on drug metabolism in mice
    • Parkinson A, Lasker J, Kramer MJ, et al: Effects of three recombinant human leucocyte interferons on drug metabolism in mice. Drug Metab Dispos 10:579-585, 1982.
    • (1982) Drug Metab Dispos , vol.10 , pp. 579-585
    • Parkinson, A.1    Lasker, J.2    Kramer, M.J.3
  • 19
    • 0026658578 scopus 로고
    • Effects of acute febrile infectious diseases in the oral pharmacokinetics and effects of nitrendapine enantiomers and bisoprolol
    • Soons PA, Grib C, Breimer DD, et al: Effects of acute febrile infectious diseases in the oral pharmacokinetics and effects of nitrendapine enantiomers and bisoprolol. Clin Pharmacokinet 23:238-248, 1992.
    • (1992) Clin Pharmacokinet , vol.23 , pp. 238-248
    • Soons, P.A.1    Grib, C.2    Breimer, D.D.3
  • 20
    • 0021280533 scopus 로고
    • Depression of cytochrome P-450 dependent drug biotransformation in hepatocytes after the activation of the RES by dextran sulphate
    • Peterson TC, Renton KW: Depression of cytochrome P-450 dependent drug biotransformation in hepatocytes after the activation of the RES by dextran sulphate. J Pharmacol Exp Ther 229:299-304, 1984.
    • (1984) J Pharmacol Exp Ther , vol.229 , pp. 299-304
    • Peterson, T.C.1    Renton, K.W.2
  • 21
    • 0027756106 scopus 로고
    • In vitro methods for assessing human hepatic drug metabolism: Their use in drug development
    • Wrighton SA, Vandenbranden M, Stevens JC, et al: In vitro methods for assessing human hepatic drug metabolism: Their use in drug development. Drug Metab Rev 25:453484, 1993.
    • (1993) Drug Metab Rev , vol.25 , pp. 453484
    • Wrighton, S.A.1    Vandenbranden, M.2    Stevens, J.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.