Use of YAC fragmentation to delimit a duplicated region on human Chromosome 21

Mammalian Genome

Volumn 7, Issue 1, 1996, Pages 85-88

  Potier, M C ^a   Dutriaux, A ^a   Reeves, R ^b  

^a CNRS   (France)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHROMOSOME 21; GENE DELETION; GENE VECTOR; GENETIC MARKER; GENETICS; HUMAN; MOLECULAR CLONING; MOLECULAR GENETICS; MULTIGENE FAMILY; NUCLEOTIDE REPEAT; NUCLEOTIDE SEQUENCE; SOUTHERN BLOTTING; TELOMERE; YEAST ARTIFICIAL CHROMOSOME;

BASE SEQUENCE; BLOTTING, SOUTHERN; CHROMOSOMES, ARTIFICIAL, YEAST; CHROMOSOMES, HUMAN, PAIR 21; CLONING, MOLECULAR; GENETIC MARKERS; GENETIC VECTORS; HUMANS; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; REPETITIVE SEQUENCES, NUCLEIC ACID; SEQUENCE DELETION; TELOMERE;

EID: 0029678618     PISSN: 09388990     EISSN: None     Source Type: Journal    
DOI: 10.1007/s003359900022     Document Type: Article

References (11)

1. Burke, D.T., Carle, G.F., Olson, M.V. (1987). Cloning of large segments of exogenous DNA into yeast by means of artificial chromosome vectors. Science 236, 806-812.
2. Campbell, C., Gulati, R., Anandi, A.K. Floy, K., Hieter, P., Kucherlapati, R.S. (1991). Generation of a nested series of interstitial deletion in yeast artificial chromosomes carrying human DNA. Proc. Natl. Acad. Sci. USA, 88, 5744-5748.
3. Chettouh, Z., Croquette, M.-F., Delobel, B., Gilgenkrants, S., Leonard, C., Maunoury, C., Prieur, M., Rethore, M.-O., Sinet, P.-M., Chery, M., Delabar, J.-M. (1995). Molecular mapping of 21 features associated with partial monosomy 21: involvement of the APP-SOD1 region. Am. J. Hum. Genet. 57, in press.
4. Dutriaux, A., Rossier, J., Van Hul, W., Nizetic, D., Theophille, D., Delabar, J.M., Van Broeckhoven, C., Potier, M.-C. (1994). Cloning and characterization of a 135- to 500-kb region of homology on the long arm of human chromosome 21. Genomics 22, 472-477.
5. Gardiner, K., Horisberger, M., Kraus, J., Tantravahi, U., Korenberg, J., Rao, V., Reddy, S., Patterson, D. (1990). Analysis of human chromosome 21: correlation of physical and cytogenetic maps; gene and CpG island distributions. EMBO J., 9, 25-34.
6. Korenberg, J.R., Kalousek, D.K., Anneren, G., Pulst, S.M., Hall, J.G., Epstein, C.J., Cox, D.R. (1991). Deletion of chromosome 21 and normal intelligence: molecular definition of the lesion. Hum. Genet., 87, 112-118.
7. Pavan, W.J., Hieter, P., Reeves, R.H. (1990). Generation of deletion derivatives by targeted transformation of human-derived yeast artificial chromosomes. Proc. Natl. Acad. Sci. USA 87, 1300-1304.
8. Pavan, W.J., Hieter, P., Sears, D., Burkoff, A., Reeves, R.H. (1991). High-efficiency yeast artificial chromosome fragmentation vectors. Gene 106, 125-127.
9. Riley, J., Butler, R., Ogilvie, D., Finniear, R., Jenner, D., Powell, S., Anand, R., Smith, J.C., Markham, A.F. (1990). A novel, rapid method for the isolation of terminal sequence from yeast artificial chromosome (YAC) clones. Nucleic Acids Res. 18, 2887-2890.
10. Riley, J.H., Morten, J.E.N., Anand, R. (1992). Targeted integration of neomycin into yeast artificial chromosomes (YACs) for transfection into mammalian cells. Nucleic Acids Res. 20, 2971-2976.
11. Spencer, F., Hugerat, Y., Simchen, G., Hurko, O., Connelly, C., Hieter P. (1994). Yeast KAR-1 mutants provide an effective method for YAC transfer to new hosts. Genomics, 22, 118-126.