The role of 5-fluorouracil dose in the adjuvant therapy of colorectal cancer

Annals of Oncology

Volumn 7, Issue 1, 1996, Pages 41-46

  Zalcberg, J R ^a   Siderov, J ^a   Simes, J ^b  

^a AUSTIN HEALTH   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

5 Fluorouracil; Colorectal carcinoma; Dose intensity; Levamisole; Total dose

Indexed keywords

CYTARABINE; FLUOROURACIL; LEVAMISOLE; MITOMYCIN C; SEMUSTINE; VINCRISTINE; ANTINEOPLASTIC AGENT; ANTINEOPLASTIC ANTIMETABOLITE;

ADJUVANT THERAPY; ARTICLE; CLINICAL TRIAL; COLORECTAL CANCER; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MAJOR CLINICAL STUDY; META ANALYSIS; PRIORITY JOURNAL; ADJUVANT CHEMOTHERAPY; COLORECTAL TUMOR; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DOSE RESPONSE; MORTALITY; RANDOMIZED CONTROLLED TRIAL;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMOTHERAPY, ADJUVANT; COLORECTAL NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUOROURACIL; HUMANS; LEVAMISOLE; RANDOMIZED CONTROLLED TRIALS;

EID: 0029678551     PISSN: 09237534     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.annonc.a010475     Document Type: Article

References (41)

1. Moertel CG, Fleming TR, MacDonald JS et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N Engl J Med 1990; 322: 352-8.
2. Buyse M, Zeleniuch-Jacquotte A, Chalmers TC. Adjuvant therapy of colorectal cancer. Why we still don't know. JAMA 1988; 259: 3571-8.
3. Gray R, James R, Mossman J, Stenning S. AXIS - a suitable case for treatment. Br J Cancer 1991; 63: 851-5.
4. Wirth A, Green M, Zalcberg JR. Adjuvant therapy of colorectal cancer: An overview. Aust NZJ Surg 1991; 61: 13-22.
5. Alberto P. Adjuvant and palliative treatments of colon cancer. Eur J Cancer 1992; 28A: 924-6.
6. Reynolds JEF (ed). Martindale. The Extra Pharmacopoeia, 30th edition. London: Pharmaceutical Press 1992.
7. Takimoto CH. Enigma of fluorouracil and levamisole. J Natl Cancer Inst 1995;87:471-3.
8. Arnaud JP, Buyse M, Nordlinger B et al. Adjuvant therapy of poor prognosis colon cancer with levamisole: Results of an EORTC double-blind randomized clinical trial. Br J Surg 1989; 76: 284-9.
9. Krauss S, Comas F, Perez C et al. Treatment of inoperable nonsmall cell carcinoma of the lung with radiation therapy, with or without levamisole. Am J Clin Oncol 1984; 7: 405-12.
10. Spitler LE. A randomized trial of levamisole versus placebo as adjuvant therapy in malignant melanoma. J Clin Oncol 1991; 9: 736-40.
11. Khoo SK, Whitaker SV, Jones ISC et al. Levamisole as adjuvant to chemotherapy of ovarian cancer: Results of a randomized trial and 4-year follow-up. Cancer 1984; 54: 986-90.
12. White JE, Chen T, Reed R et al. Limited squamous cell carcinoma of the lung: A Southwest Oncology Group randomized study of radiation with or without doxorobucin chemotherapy and with or without levamisole immunotherapy. Cancer Treat Rep 1982; 66: 1113-20.
13. Disney APS (ed). Fourteenth Report of the Australia and New Zealand Dialysis and Transplant Registry (ANZDATA), Adelaide, South Australia 1991.
14. Arbuck S. Overview of clinical trials using 5-fluorouracil and leucovorin for the treatment of colorectal cancer. Cancer 1989; 63: 1036-44.
15. Erlichman C, Marsoni S, Seitz JF et al. Event free and overall survival is increased by FUFA in resected B and C colon cancer. A prospective pooled analysis of 3 randomised trials (RCTS). Proc Am Soc Clin Oncol 1994; 13: 194 (Abstr 562).
16. International Multicentre Pooled Analysis of Colon Cancer Trials (IMPACT) investigators. Efficacy of adjuvant fluorouracil and folinic acid in colon cancer. Lancet 1995; 345: 939-44.
17. Laurie JA, Moertel CG, Fleming TR et al. Surgical adjuvant therapy of large-bowel carcinoma: An evaluation of levamisole and the combination of levamisole and fluorouracil. J Clin Onol 1989; 7: 1447-56.
18. Krook JE, Moertel CG, Gunderson LL et al. Effective surgical adjuvant therapy for high-risk rectal carcinoma. N Engl J Med 1991; 324: 709-15.
19. Early Breast Cancer Triallists' Collaborative Group. Systemic treatment of early breast cancer by hormonal, cytotoxic, or immune therapy. Lancet 1992; 339: 1-15, 71-85.
20. Armitage P, Berry G. Statistical Methods in Medical Research. Oxford: Blackwell Scientific Publications 1971; 312-8.
21. Grage TB, Moss SE. Adjuvant therapy in cancer of the colon and rectum: Demonstration of effectiveness of prolonged 5-FU chemotherapy in a prospectively controlled, randomized trial. Surg Clin North Am 1981; 61: 1321-9.
22. Grage TB, Hill GJ, Cornell GN et al. Adjuvant chemotherapy in large-bowel cancer: Demonstration of effectiveness of single agent chemotherapy in a prospectively controlled, randomised trial. Recent Results Cancer Res 1978; 68: 222-30.
23. Grage TB, Metter GE, Cornell GN et al. Adjuvant chemotherapy with 5-fluorouracil after surgical resection of colorectal carcinoma (COG Protocol 7041). Am J Surg 1977; 133: 59-66.
24. Higgins GA, Lee LE, Dwight RW et al. The case for adjuvant 5-fluorouracil in colorectal cancer. Cancer Clin Trials 1978; 1: 35-41.
25. Higgins GA, Humphrey E, Juler GL et al. Adjuvant chemotherapy in the surgical treatment of large bowel cancer. Cancer 1976; 38: 1461-7.
26. Wolmark N, Fisher B, Rockette H et al. Postoperative adjuvant chemotherapy or BCG for colon cancer: Results from NSABP Protocol C-01. J Natl Cancer Inst 1988; 80: 30-6.
27. Fisher B, Wolmark N, Rockette H et al. Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: Results from NSABP Protocol R-01. J Natl Cancer Inst 1988; 80: 21-9.
28. Gastrointestinal Tumour Study Group. Survival after postoperative combination treatment of rectal cancer. N Engl J Med 1986; 315: 9.
29. Gastrointestinal Tumour Study Group. Prolongation of the disease-free interval in surgically treated rectal carcinoma. N Engl J Med 1985; 312: 1465-72.
30. Gastrointestinal Tumour Study Group. Adjuvant therapy of colon cancer - results of a prospectively randomised trial. N Engl J Med 1986; 310: 737-43.
31. Lawrence W Jr. Terz JJ, Horsley JS et al. Chemotherapy as an adjuvant to surgery for colorectal cancer. Arch Surg 1978; 113: 164-8.
32. Lawrence W Jr, Terz JJ, Horsley JS et al. Chemotherapy as an adjuvant to surgery for colorectal cancer. Arch Surg 1975; 181: 616-23.
33. Higgins GA, Amadeo JH, McElhinney J et al. Efficacy of prolonged intermittent therapy wit combined 5-fluorouracil and methyl-CCNU following resection for carcinoma of the large bowel. Cancer 1984; 53: 1-8.
34. Panettiere FJ, Goodman PJ, Costanzi JJ et al. Adjuvant therapy in large bowel adenocarcinoma: Long-term results of a Southwest Oncology Group Study. J Clin Oncol 1988; 6: 947-54.
35. Wunderlich M, Schiessel R, Rainer H et al. Effect of adjuvant chemo- or immunotherapy on the prognosis of colorectal cancer operated for cure. Br J Surg 1985; 72(Suppl): 107-10.
36. Rainer H, Kovats E, Lehman HG et al. Effectiveness of postoperatie adjuvant therapy with cytotoxic chemotherapy (cytosine arabinoside. mitomycin C, 5-fluorouracil) or immunotherapy (neuraminidase-modified allogenic cells) in the prevention of recurrence of Dukes' D and C colon cancer. Recent Results Cancer Res 1981; 79: 41-7.
37. Higgins GA, Dwight RW, Smith JV et al. Fluorouracil as an adjuvant to surgery in carcinoma of the colon. Arch Surg 1971; 102: 339-43.
38. Irvin T, Vowles KDJ, Golby MG. Fluorouracil in chemoprophylaxis of colorectal cancer. Results of a controlled clinical trial. Dis Colon Rectum 1986; 29: 704-6.
39. Hafstrom L, Rudenstam CM, Domellof A. A randomized trial of oral 5-fluorouracil versus placebo as adjuvant therapy in colorectal cancer Dukes B and C: Results after 5 years observation time. Br J Surg 1985; 72: 138-41.
40. Bancewicz J, Calman KC, MacPherson SG et al. Adjuvant chemotherapy and immunotherapy for colorectal cancer: Preliminary communication. J R Soc Med 1980; 73: 197-9.
41. Hryniuk WM. The importance of dose intensity in the outcome of chemotherapy. In De Vita V, Hellman S, Rosenberg S (eds): Important Advances in Oncology. Philadelphia: Lippincott Company 1988.