7-nitro indazole, a selective neuronal nitric oxide synthase inhibitor in vivo, impairs spatial learning in the rat

Learning and Memory

Volumn 2, Issue 6, 1996, Pages 267-278

  Hölscher, Christian ^a   McGlinchey, Liam ^a   Anwyl, Roger ^a   Rowan, Michael J ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

7 NITROINDAZOLE; 7-NITROINDAZOLE; ENZYME INHIBITOR; INDAZOLE DERIVATIVE; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE; NOS1 PROTEIN, RAT;

ANIMAL; ARTICLE; CHEMICAL PHENOMENA; DRUG ANTAGONISM; DRUG EFFECT; LEARNING; MALE; MAZE TEST; RAT; WISTAR RAT;

ANIMALS; DEPRESSION, CHEMICAL; ENZYME INHIBITORS; INDAZOLES; MALE; MAZE LEARNING; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE I; RATS; RATS, WISTAR; REVERSAL LEARNING; TRANSFER (PSYCHOLOGY);

EID: 0029677230     PISSN: 10720502     EISSN: None     Source Type: Journal    
DOI: 10.1101/lm.2.6.267     Document Type: Article

References (5)

1. Amir, S. 1992. Blocking NMDA receptors or nitric oxide production disrupts light transmission to the suprachiasmatic nucleus. Brain Res. 586: 336-339.
2. Babbedge, R.C., P.A. Blandward, S.L. Hart, and P.K. Moore. 1993. Inhibition of rat cerebellar nitric-oxide synthase by 7-nitro-indazole and related substituted indazoles. Br. J. Pharmacol. 110: 225-228.
3. Bannerman, D.M., P.F. Chapman, P.A.T. Kelly, S.P. Butcher, and R.G.M. Morris. 1994a. Inhibition of nitric-oxide synthase does not impair spatial learning. J. Neurosci. 14: 7404-7414.
4. Bannerman, D.M., S.P. Butcher, and R.G.M. Morris. 1994b. Intracerebroventricular injection of a nitric oxide synthase inhibitor does not affect long-term slope potentiation in vivo. Neuropharmacology 33: 1387-1397.
5. Received November 2, 1995; accepted in revised form April 1, 1996.