Gene expression of interleukin-3 and granulocyte macrophage colony-stimulating factor in circulating CD4+ T cells in acute severe asthma

Clinical and Experimental Allergy

Volumn 26, Issue 2, 1996, Pages 138-146

  Lai, C K W ^a   Ho, S S ^a   Chan, C H S ^a   Leung, R ^a   Lai, K N ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Asthma; Corticosteroids; Cytokines; Eosinophil cationic protein; Eosinophils; Granulocyte macrophage colony stimulating factor; Interleukin 3; T lymphocytes

Indexed keywords

CD4 ANTIGEN; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; INTERLEUKIN 3; MESSENGER RNA; PROTEIN;

ADULT; ARTICLE; ASTHMA; CONTROLLED STUDY; EOSINOPHIL; FEMALE; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION;

ACUTE DISEASE; ADULT; ASTHMA; BLOOD PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; EOSINOPHIL GRANULE PROTEINS; FEMALE; GENE EXPRESSION; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; INTERLEUKIN-3; MALE; MIDDLE AGED; PEAK EXPIRATORY FLOW RATE; POLYMERASE CHAIN REACTION; RIBONUCLEASES; RNA, MESSENGER;

EID: 0029671394     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2222.1996.tb00072.x     Document Type: Article

References (36)

1. Djukanovic R, Wilson JW, Britten KM et al. Mucosal inflammation in asthma. Am Rev Respir Dis 1990; 142: 434-57.
2. Bousquet J, Chanez P, Lacoste JY et al. Eosinophilic inflammation in asthma. N Engl J Med 1990; 323:1033-9.
3. Lai CKW, Chan CHS, Leung JCK, Lai KN. Serum concentration of soluble interleukin 2 receptors in asthma: correlation with disease activity. Chest 1993; 103:782-6.
4. Monteforte S, Lai CKW, Kapahi P et al. Circulating adhesion molecules in asthma. Am J Respir Crit Care Med 1994; 149:1149-52.
5. Venge P. Serum measurements of eosinophil cationic protein (ECP) in bronchial asthma. Clin Exp Allergy 1993; 23(suppl. 2):3-7.
6. Gleich GJ. The eosinophil and bronchial asthma: current understanding. J Allergy Clin Immunol 1990; 85:422-36.
7. Kay AB. T cells, cytokines and asthma. J R Coll Physicians Lond 1994; 28:325-31.
8. Weller PF. Cytokine regulation of eosinophil function. Clin Immunol Immunopathol 1992; 62:S55-9.
9. Hamid Q, Azzawi M, Ying S et al. Expression of mRNA for interleukin-5 in mucosal bronchial biopsies from asthma. J Clin Invest 1991; 87:1541-6.
10. Robinson DS, Hamid Q, Ying S et al. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. N Engl J Med 1992; 326:298-304.
11. Robinson DS, Ying S, Bentley AM et al. Relationships among numbers of bronchoalveolar lavage cells expressing mRNA for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma. J Allergy Clin Immunol 1993; 92:397-403.
12. Robinson DS, Hamid Q, Bentley AM et al. Activation of CD4+ T cells and increased IL-4, IL-5, and GM-CSF mRNA positive cells in bronchoalveolar lavage fluid (BAL) 24 hours after allergen inhalation challenge of atopic asthmatic patients. J Allergy Clin lmmunol 1993; 92:313-24.
13. Wooley KL, Adelroth E, Woolley MJ et al. Granulocyte-macrophage colony-stimulating factor, eosinophils and eosinophil cationic protein in subjects with and without mild, stable, atopic asthma. Eur Respir J 1994; 7:1576-84.
14. Lai CKW, Ho SS, Tang J, Chan CHS, Lai KN. Interleukin-5 (IL-5) messenger RNA expression in peripheral blood CD4+ cells in asthma. Am J Respir Crit Care Med 1994; 149:A961.
15. Lai KN, Leung J, Li PKT, Larche M, Ritter MA. The effects of blockade of interleukin 2 receptors and interleukin 4 receptors on cytokine production. APMIS 1991; 99:434-42.
16. Lai KN, Leung JCK, Li PKT, Lui SF. Cytokine production by peripheral blood mononuclear cells in IgA nephropathy. Clin Exp Immunol 1991; 85:240-5.
17. Leung JCK, Lai CKW, Chui YL et al. Characterization of cytokine gene expression in CD4+ and CD8+ T cells after activation with phorbol myristate acetate and phytohaemagglutinin. Clin Exp lmmunol 1992; 90:147-53.
18. Brenner CA, Tam AW, Nelson PA et al. Message amplification phenotyping (MAPPing): a technique to simultaneously measure mRNAs from small numbers of cells. BioTechniques 1989; 7:1096-103.
19. Peterson CGB, Enander I, Nystrand J et al. Radioimmunoassay of human eosinophil cationic protein (ECP) by an improved method. Establishment of normal levels in serum and turnover in vivo. Clin Exp Allergy 1991; 21:561-7.
20. Murphy LD, Herzog CE, Rudick JB et al. Use of the polymerase chain reaction in the quantification of mdr-1 gene expression. Biochemistry 1990; 29:10351-6.
21. Corrigan CJ, Hartnell A, Kay AB. T lymphocyte activation in acute severe asthma. Lancet 1988; 1:1129-31.
22. Corrigan CJ, Kay AB. CD4 T-lymphocyte activation in acute severe asthma: relationship to disease activity and atopic status. Am Rev Respir Dis 1990; 141:970-7.
23. Brown PH, Crompton GK, Greening AP. Proinflammatory cytokines in acute asthma. Lancet 1991;338:590-3.
24. Corrigan CJ, Haczku A, Gemou-Engesaeth et al. CD4 T-lymphocyte activation in asthma is accompanied by increased serum concentrations of interleukin-5: effect of glucocorticoid therapy. Am Rev Respir Dis 1993; 147:540-7.
25. Alexander AG, Barkans J, Moqbel R et al. Serum interleukin 5 concentrations in atopic and non-atopic patients with glucocorticoid-dependent chronic severe asthma. Thorax 1994; 49:1231-3.
26. van Leeuwen BH, Martinson ME, Webb GC, Young IG. Molecular organisation of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5 and GM-CSF genes, on human chromosome 5. Blood 1989; 73:1142-8.
27. Cockerill PN, Shannon MF, Bert AG, Ryan GR, Vadas MA. The granulocyte-macrophage colony-stimulating factor/interleukin-3 locus is regulated by an inducible cyclosporin A-sensitive enhancer. Proc Natl Acad Sci USA 1993; 90:2466-79.
28. Lee HJ, Koyano-Nakagawa N, Naito Y et al. cAMP activates IL-5 promoter synergistically with phorbol ester through the signaling pathway involving protein kinase A in mouse thymoma line EL-4. J Immunol 1993; 151:6135-42.
29. Kelly EAB, Hoffman DP, Busse WW, Jariour NN. Differential regulation of TH1- and TH2-associated cytokines by the β-adrenergic agonist, albuterol. Am J Respir Crit Care Med 1995 (abstract book: in press).
30. Lane SJ, Wilkinson JRW, Cochrane GM, Lee TH, Arm JP. Differential in vitro regulation by glucocorticosteroids of monocyte-derived cytokine generation in glucocorticoid-resistant bronchial asthma. Am Rev Respir Dis 1993; 147: 690-6.
31. Sousa AR, Poston RN, Lane SJ, Nakhosteen JA, Lee TH. Detection of GM-CSF in asthmatic bronchial epithelium and decrease by inhaled corticosteroids. Am Rev Respir Dis 1993; 147:1557-61.
32. Wang JH, Trigg CJ, Devalia JL, Jordan S, Davis RJ. Effect of inhaled beclomethasone dipropionate on expression of proinflammatory cytokines and activated eosinophils in the bronchial epithelium of patients with mild asthma. J Allergy Clin Immunol 1994; 94:1025-34.
33. Robinson D, Hamid Q, Ying S et al. Prednisolone treatment in asthma is associated with modulation of bronchoalveolar lavage cell interleukin-4, interleukin-5, and interferon-g cytokine gene expression. Am Rev Respir Dis 1993; 148:401-6.
34. Vadas M, Lopez A, Gamble J et al. Cytokines and allergy. J Allergy Clin Immunol 1994; 94:1289-93.
35. Broide DH, Paine MM, Firestein GS. Eosinophils express interleukin-5 and granulocyte macrophage colony-stimulating factor mRNA at sites of allergic inflammation in asthmatics. J Clin Invest 1992; 90:1414-24.
36. Marini M, Soloperto M, Mezzetti M, Fasoli A, Mattoli S. Interleukin-1 binds to specific receptors on human bronchial epithelial cells and upregulates granulocyte-macrophage colony-stimulating factor synthesis and release. Am J Respir Cell Mol Biol 1991; 4:519-24.