trans-Acting proteins involved in RNA encapsidation and viral assembly in human immunodeficiency virus type

Journal of Virology

Volumn 70, Issue 2, 1996, Pages 880-886

  Kaye, Jane F ^a   Lever, Andrew M L ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAG PROTEIN; POL PROTEIN; PROTEINASE; TRANS ACTING FACTOR; VIRUS RNA;

ANIMAL CELL; ARTICLE; CELL STRAIN COS1; CONTROLLED STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LEUKEMIA CELL LINE; NONHUMAN; PRIORITY JOURNAL; RNA TRANSPORT; T LYMPHOCYTE SUBPOPULATION; VIRUS ASSEMBLY; VIRUS CAPSID; VIRUS GENOME; VIRUS NUCLEOCAPSID; VIRUS PARTICLE;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CELL LINE; GENE PRODUCTS, GAG; GENE PRODUCTS, POL; GENES, GAG; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN PRECURSORS; RNA, VIRAL; TRANS-ACTIVATORS; VIRION; VIRUS ASSEMBLY;

EID: 0029671218     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/jvi.70.2.880-886.1996     Document Type: Article

References (62)

1. Adam, M. A., and A. D. Miller. 1988. Identification of a signal in a murine retrovirus that is sufficient for packaging of nonretroviral RNA into virions. J Virol. 62:3802-3806.
2. Aldovini, A., and R. A. Young. 1990 Mutations of RNA and protein sequences involved in human immunodeficiency virus type 1 packaging result in production of noninfectious virus. J. Virol. 64:1920-1926
3. Allain, B., M. Lapadat-Tapolsky, C. Berlioz, and J.-L. Darlix. 1994. Transactivation of the minus-strand DNA transfer by nucleocapsid protein during reverse transcription of the retroviral genome. EMBO J. 13:973-981
4. Aronoff, R., A. M. Hajjar, and M. L. Linial. 1993. Avian retroviral RNA encapsidation: reexamination of functional 5′ RNA sequences and the role of nucleocapsid Cys-His motifs. J. Virol. 67:178-188.
5. Baudin, F., R. Marquet, C. Isel, J.-L. Darlix, B. Ehresmann, and C. Ehresmann. 1993 Functional sites in the 5′ region of human immunodeficiency virus type 1 RNA form defined structural domains J. Mol Biol. 229:382-397.
6. Bender, M. A., T. D. Palmer, R. E. Gelinas, and A. D. Miller. 1987. Evidence that the packaging signal of Moloney murine leukemia virus, extends into the gag region. J. Virol. 61:1639-1646
7. Berg, J. 1986 Potential metal-binding domains in nucleic acid binding proteins. Science 232:485-487
8. Berkowitz, R. D., J. Luban, and S. P. Goff. 1993. Specific binding of human immunodeficiency virus type 1 gag polyprotein and nucleocapsid to viral RNAs detected by RNA mobility shift assays. J Virol 67:7190-7200.
9. Bryant, M., and L. Ratner. 1990. Myristoylation-dependem replication and assembly of human immunodeficiency virus 1. Proc. Natl. Acad Sci. USA 87: 523-527.
10. Bukrinskaya, A. G., G. K. Vorkunova, and Y. Y. Tentsov. 1993. HIV-1 matrix protein p17 is translocated into the cell-nucleus and binds to viral genomic RNA. Mol Biol. 27:22-27.
11. Bukrinsky, M. I., S. Haggerty, M. P. Dempsey, N. Sharova, A. Adzhubei, L. Spitz, P. Lewis, D. Goldfarb, M. Emerman, and M. Stevenson. 1993. A nuclear localization signal within HIV-1 matrix protein that governs infection of nondividing cells. Nature (London) 365:666-669.
12. Clavel, F., and J. M. Orenstein. 1990 A mutant of human immunodeficiency virus with reduced RNA packaging and abnormal particle morphology J. Virol. 64:5230-5234.
13. Clever, J., C. Sassetti, and T. G. Parslow. 1995. RNA secondary structure and binding sites for gag gene products in the 5′ packaging signal of human immunodeficiency virus type 1. J. Virol. 69:2101-2109.
14. Covey, S. N. 1986. Amino acid sequence homology in a gag region of reverse transcribing elements and the coal protein gene of cauliflower mosaic virus. Nucleic Acids Res. 14:623-633.
15. Dannull, J., A. Surovoy, G. Jung, and K. Moelling. 1994. Specific binding of HIV-1 nucleocapsid protein to PSI RNA in vitro requires N-terminal zinc finger and flanking basic amino acid residues. EMBO J. 13:1525-1533.
16. De Rocquigny, H., C. Gabus, A. Vincent, M.-C. Fournié-Zaluski, B. Roques, and J.-L. Darlix. 1992. Viral RNA annealing activities of human immunodeficiency virus type 1 nucleocapsid protein require only peptide domains outside the zinc fingers. Proc. Natl. Acad. Sci. USA 89:6472-6576.
17. Dupraz, P., S. Oertle, C. Meric, P. Damay, and P.-F. Spahr, 1990. Point mutations in the proximal Cys-His box of Rous sarcoma virus nueleocapsid protein. J Virol. 61:4978-4987
18. Fisher, A. G., E. Collati, L. Ratner, R. C. Gallo, and F. Wong-Staal. 1985. A molecular clone of HTLV-III with biological activity. Nature (London) 316: 262-265.
19. Fujimura, T., J. C. Ribas, A. M. Makhov, and R. B. Wickner. 1992. Pol of gag-pol fusion protein required for encapsidation of viral RNA of yeast L-A virus. Nature (London) 359:746-749.
20. gag virus-like particles from recombinant baculovirus-infected cells. Cell 59:103-112.
21. 20a.Gorelick, R. J., D. J. Chabot, A. Rein, L. E. Henderson, and L. O. Arthur. 1993 The two zinc fingers in the human immunodeficiency virus type 1 nucleocapsid protein are not functionally equivalent J. Virol. 67:4027-4036.
22. Gorelick, R. J., L. E. Henderson, J. P. Hanser, and A. Rein. 1988. Point mutants of Moloney murine leukemia virus that fail to package viral RNA evidence for specific RNA recognition by a "zinc finger-like" protein sequence. Proc. Natl. Acad. Sci. USA 85:8420-8424.
23. Gorelick, R. J., S. M. Nigida, Jr., J. R. Bess, Jr., L. O. Arthur, L. E. Henderson, and A. Rein. 1990. Noninfectious human immunodeficiency virus type 1 mutants deficient in genomic RNA. J. Virol. 64:3207-3211.
24. Gottlinger, H. G., T. Dorfman, J. G. Sodroski, and W. A. Haseltine. 1991. Effects of mutations affecting the Pr6 Gag protein on human immunodeficiency virus particle release. Proc Natl. Acad. Sci USA 88:3195-3199
25. Gottlinger, H. G., J. G. Sodroski, and W. A. Haseltine. 1989. Role of capsid precursor processing and myristylation in morphogenesis and infectivity of human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA 86:5781-5785.
26. Guy, B., M. Geist, K. Dott, D. Spehner, M.-P. Kieny, and J.-P. Lecocq. 1991. A specific inhibitor of cysteine proteases impairs a Vif-dependem modification of human immunodeficiency virus type 1 Env protein. J. Virol. 65:1325-1331.
27. Hansen, M. S. T., and E. Barklis. 1995. Structural interactions between retroviral Gag proteins examined by cysteine cross-linking. J. Virol. 69: 1150-1159.
28. Harrison, G. P., and A. M. L. Lever. 1992. The human immunodeficiency virus type 1 packaging signal and major splice donor region have a conserved stable secondary structure. J Virol. 66:4144-4153.
29. Hayashi, T., T. Shioda, Y. Iwakura, and H. Shibuta. 1992. RNA packaging signal of human immunodeficiency virus type 1 Virology 188:590-599.
30. Jentoff, J. E., L. M. Smith, X. Fu, M. Johnson, and J. Leis. 1988. Conserved cysteine and histidine residues of the avian myeloblastosis virus nucleocapsid protein are essential for viral replication hut not "zinc-binding fingers." Proc. Natl Acad. Sci USA 85:7094-7098.
31. Jowett, J. M. B., D. J. Hockley, M. V. Nermut, and I. M. Junes. 1992. Distinct signals in human immunodeficiency virus type 1 Pr55 necessary for RNA binding and particle formation. J. Gen. Virol. 73:3079-3086.
32. Karacostas, V., K. Nagashima, M. A. Gonda, and B. Moss. 1989. Human immunodeficiency virus-like particles produced by a vaccinia virus, expression vector. Proc. Nat!. Acad. Sci. USA 86:8964-8967.
33. Katz, R. A., R. W. Terry, and A. M. Skalka. 1986. A conserved cis-acting sequence in the 5′ leader of avian sarcoma virus RNA is required for packaging J Virol. 59:163-167.
34. Kowatski, M., J. Potz, L. Basiripour, T. Dorfman, W. C. Goh, E. Terwilliger, A. Dayton, C. Rosen, W. Haseltine, and J. Sodroski. 1987. Functional regions of the envelope glycoprotein of human immunodeficiency virus type 1. Science 237:1351-1355.
35. Lapadat-Tapolsky, M., H. De Rocquigny, D. Vangent, B. Roques, R. Plasterk, and J.-L. Darlix. 1993. Interactions between HIV-1 nucleocapsid protein and viral-DNA may have important functions in the viral life-cycle. Nucleic Acids Res 21:831-839.
36. 34a.Lee, P. P., and M. L. Linial. 1994 Efficient particle formation can occur if the matrix domain of human immunodeficiency virus type 1 Gag is substituted by a myristylation signal J. Virol. 68:6644-6654.
37. Lever, A. 1991. Regulatory proteins of HIV Rev. Med. Virol. 1:155-163.
38. Lever, A., H. Gottlinger, W. Haseltine, and J. Sodroski. 1989. Identification of a sequence required for efficient packaging of human immunodeficiency virus type 1 RNA into virions. J. Virol. 63:4085-1087
39. Luban, J., and S. P. Gaff. 1991. Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein. J. Virol. 65: 3203-3212.
40. Mann, R., R. C. Mulligan, and D. Baltimore. 1983 Construction of a retroviral packaging mutant and its use to produce helper free defective retrovirus. Cell 33:153-159.
41. Mergener, K., M. Facke, R. Welker, V. Brinkmann, H. R. Gelderblom, and H.-G. Kransslich. 1992. Analysis of HIV particle formation using transient expression of subviral constructs in mammalian cells. Virology 186:25-39.
42. Méric, C., and S. P. Goff. 1989. Characterization of Moloney murine leukemia virus mutants with single-amino-acid substitutions in the Cys-His box of the nucleocapsid protein. J. Virol. 63:1558-1568.
43. 1H NMR. EMBO J. 11:3059-3065.
44. Oertle, S., and P.-F. Spahr. 1990. Role of the gag polyprotein precursor in packaging and maturation of Rous sarcoma virus genomic RNA. J. Virol. 64: 5757-5763
45. Omichinski, J., G. M. Clore, K. Sakaguchi, E. Appells, and A. M. Gronenborn. 1991. Structural characterization of a 39-residue synthetic peptide containing the two zinc binding domains from the HIV-1 p7 nucleocapsid protein by CD and NMR spectroscopy. FEES Lett. 292:25-30.
46. Park, J., and C. D. Morrow. 1991. Overexpression of the gag-pol precursor from human immunodeficiency virus type 1 proviral genomes results in efficient proteolytic processing in the absence of virion production. J. Virol. 65:5111-5117.
47. gag and is incorporated into viruslike particles. J. Virol 66:6304-6313.
48. Potter, H. 1987. Transfection by electroporation, p. 9.3.1-9.3 3. In R Ausubel. R. E. Brent, D. D. Kingston, J. G. Moore, J A. Seidman, J. A. Smith, and K. Struhl (ed.). Current protocols in molecular biology, vol. 1. Greene Publishing Associates and Wiley Interscience, New York.
49. Richardson, J. H., L. A. Child, and A. M. L. Lever. 1993. Packaging of human immunodeficiency virus type 1 RNA requires cis-actins. sequences outside the 5′ leader region. J. Virol. 67:3997-4005.
50. Rosen, C. A., J. G. Sodroski, K. Campbell, and W. A. Haseltine. 1986. Construction of recombinant murine retroviruses that express the human T-cell leukemia virus type III and human T-cell lymphotropic virus typo III trans activator genes. J. Virol. 57:379-384.
51. Sakaguchi, K., N. Zambrano, E. T. Baldwin, B. A. Shapiro, J. W. Erickson, J. G. Omichinski, G. M. Clore, A. M. Gronenborn, and E. Appella. 1993 Identification of a binding site for the human immunodeficiency virus type 1 nucleocapsid protein. Proc. Natl. Acad. Sci. USA 90:5219-5223.
52. Selden, R. F. 1987. Transfection using DEAE-dextran. p 9.2.1-9 2.6. In R. Ausubel, R. E. Brent, D. D. Kingston, J. G. Moore, J. A. Seidman, J A. Smith, and K. Struhl (ed.). Current protocols in molecular biology. vol 1. Greene Publishing Associates and Wiley Interscience. New York.
53. Shields, A., W. N. Witte, E. Rothenberg, and U. Baltimore. 1978. High frequency of aberrant expression of Moloney murine leukemia virus in clonal infections. Cell 14:601-609.
54. Shioda, T., and H. Shibuta. 1990. Production of human immunodeficiency virus (HIV)-like particles from cells infected with recombinant vaccinia viruses carrying the gag gene of HIV. Virology 175:139-148
55. gag-pol expressed from a simian virus 40 late replacement vector are efficiently processed and assembled into viruslike particles. J. Virol. 64:2743-2750.
56. gag-pol from human immunodeficiency virus type 1 into virus-like particles. J Virol. 67:2266-2275
57. South, T. L., and M. F. Summers. 1993 Zinc- and sequence-dependent binding to nucleic acids by the N-terminal zinc finger of the HIV-1 nucleocapsid protein NMR structure of the complex with the psi-site analog, dACGCC. Protein Sci. 2:3-19.
58. Tenwilliger, E., B. Godin, J. G. Sodroski, and W. A. Haseltine. 1989. Construction and use of a replication-competent human immunodeficiency virus (HIV-1) that expresses the chloramphenicol acetyltransferase enzyme Proc. Natl. Acad. Sci. USA 86:3857-3861.
59. Terwilliger, E., J. Proulx, J. Sodroski, and W. A. Haseltine. 1988. Cell lines that express stably env gene products from three strains of HIV-1. J Acquired Immune Defic. Syndr. 1:317-323.
60. 57a Wang, C.-T., and E. Barklis. 1993. Assembly, processing and infectivity of human immunodeficiency virus type 1 Gag mutants. J. Virol. 67:4264-1273.
61. Watanabe, S., and H. M. Temin. 1982. Encapsidation sequences for spleen necrosis virus, an avian retrovirus, are between the 5′ long terminal repeat and the start of the gag gene Proc. Natl. Acad Sci. USA 79:5986-5990.
62. Wills, J. W., and R. C. Craven. 1991 Form, function, and use of retroviral gag proteins. AIDS 5:639-654.