Effect of (±)-8-hydroxy-2-(di-n-propylamino)tetralin hydrobromide on spinal motor systems in anesthetized intact and spinalized rats

European Journal of Pharmacology

Volumn 295, Issue 2-3, 1996, Pages 211-214

  Hasegawa, Yutaka ^a   Ono, Hideki ^a  

^a UNIVERSITY OF TOKYO   (Japan)

Author keywords

5 HT1A receptor; 8 OH DPAT (( ) 8 hydroxy 2 (di n propylamino)tetralin hydrobromide); Motor function; Spinal cord; Spinal reflex

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; SEROTONIN 1A AGONIST;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; INTRAVENOUS DRUG ADMINISTRATION; MALE; MONOSYNAPTIC REFLEX; MOTOR PERFORMANCE; NONHUMAN; POLYSYNAPTIC REFLEX; PRIORITY JOURNAL; RAT; SPINAL CORD TRANSSECTION; SPINAL REFLEX;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; RATS; RATS, WISTAR; REFLEX; SPINAL CORD;

EID: 0029671209     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00759-8     Document Type: Article

References (20)

1. Anderson, E.G. and T. Shibuya, 1966, The effect of 5-hydroxytryptophan and 1-tryptophan on spinal synaptic activity, J. Pharmacol. Exp. Ther. 153, 352.
2. Barasi, S. and M.H.T. Roberts, 1974, The modification of lumbar motoneurone excitability by stimulation of a putative 5-hydroxytryptamine pathway, Br. J. Pharmacol. 52, 339.
3. Basbaum, A.I., F. Godefroy and J. Weil-Fugazza, 1987, A new microdissection technique for regional biochemical analysis of the spinal cord: serotonin, norepinephrine, dopamine and uric acid, Brain Res. 419, 229.
4. 1A receptors in the dorsal raphe and hippocampus. I. Effect of spiperone, J. Pharmacol. Exp. Ther. 265, 7.
5. Carels, G., 1962, Depression par la serotonone de la transgrenouille, Arch. Int. Pharmacodyn. 138, 326.
6. Connell, L.A. and D.I. Wallis, 1988, Responses to 5-hydroxytryptamine evoked in the hemisected spinal cord of the neonate rat, Br. J. Pharmacol. 94, 1101.
7. Crick, H. and D.I. Wallis,1991, Inhibition of reflex responses of neonate rat lumbar spinal cord by 5-hydroxytryptamine, Br. J. Pharmacol. 103, 1769.
8. Dahlström, A. and K. Fuxe, 1964, Evidence for the existence of monoamine-containing neurons in the central nervous system. I. Demonstration of monoamines in the cell bodies of brain stem neurons, Acta Physiol. Scand. 62 (Suppl. 232), 3.
9. Hall, E.D., 1981, Non-serotonergic depression of spinal monosynaptic reflex transmission by 5-hydroxytryptophan, Neuropharmacology 20, 109.
10. Martin, G.F., T. Cabana, F.J. Ditirro, R.H. Ho and A.O. Humbertson, 1982, Raphespinal projections in the North American opossum: evidence for connectional heterogeneity, J. Comp. Neurol. 208, 67.
11. Nagano, N., H. Ono, M. Ozawa and H. Fukuda, 1988, The spinal reflex of chronic spinal rat is supersensitive to 5-HTP but not to TRH or 5-HT agonists, Eur. J. Pharmacol. 149, 337.
12. Nygren, L.-G., L. Fuxe, G. Jonsson and L. Olson, 1974, Functional regeneration of 5-hydroxytryptamine nerve terminals in the rat spinal cord following 5,6-dihydroxytryptamine induced degeneration, Brain Res. 78, 377.
13. Roberts, M.H.T., M. Davies, D. Girdlestone and G.A. Foster, 1988, Effects of 5-hydroxytryptamine agonists and antagonists on the responses of rat spinal motoneurones to raphe obscurus stimulation, Br. J. Pharmacol. 95, 437.
14. Saito, K., S. Ito, T. Kitazawa and A. Ohga, 1982, Selective inhibition by methysergide of the monosynaptic reflex discharge in the isolated spinal cord of the newborn rat, Brain Res. 251, 117.
15. 7 receptor positively coupled to adenylyl cyclase, J. Neurochem. 63, 456.
16. Wallis, D.I., J. Wu and X. Wang, 1993, Descending inhibition in the neonate rat spinal cord is mediated by 5-hydroxytryptamine. Neuropharmacology 32, 73.
17. White, S.R. and S.J. Fung, 1989, Serotonin depolarizes cat spinal motoneurons in situ and decreases motoneuron afterhyperpolarizing potentials, Brain Res. 50 2, 205.
18. Wiklund, L., L. Leger and M. Persson, 1981, Monoamine cell distribution in the cat brain stem: a fluorescence histochemical study with quantification of indoleaminergic and locus coeruleus cell groups, J. Comp. Neurol. 203, 613.
19. 1 receptors attenuates synaptic transmission to immature rat motoneurons in vitro, Brain Res. 554, 111.
20. Yamazaki, J., H. Ono and T. Nagao, 1991, Stimulatory and inhibitory effects of serotoninergic hallucinogens on spinal mono- and polysynaptic reflex pathways in the rat, Neuropharmacology 31, 635.