All-trans β-carotene enhances mitogenic responses and ornithine decarboxylase activity of BALB/c 3T3 fibroblast cells induced by tumor promoter and fetal bovine serum but suppresses mutagen-dependent umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002)

Cancer Letters

Volumn 99, Issue 1, 1996, Pages 15-21

  Okai, Yasuji ^a   Higashi Okai, Kiyoka ^a   Yano, Yoshihisa ^b   Otani, Shuzo ^b  

^a Osaka Kun ei Women's College   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Antimutagenesis; Cell proliferation; Ornithine decarboxylase; Tumor promotion; Carotene

Indexed keywords

2 AMINOANTHRACENE; BETA CAROTENE; ORNITHINE DECARBOXYLASE;

ANIMAL CELL; ARTICLE; BACTERIAL GENE; CELL STRAIN 3T3; DNA SYNTHESIS; FETAL CALF SERUM; GENE REPRESSION; MITOGENESIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; SALMONELLA TYPHIMURIUM; TUMOR PROMOTION;

3T3 CELLS; ANIMALS; ANTHRACENES; ANTIMUTAGENIC AGENTS; BACTERIAL PROTEINS; BETA CAROTENE; CARCINOGENS; CAROTENOIDS; CATTLE; CELL DIVISION; DNA; DNA-DIRECTED DNA POLYMERASE; DRUG INTERACTIONS; ENZYME INDUCTION; ESCHERICHIA COLI PROTEINS; FETAL BLOOD; GENE EXPRESSION; MICE; MICE, INBRED BALB C; MUTAGENS; ORNITHINE DECARBOXYLASE; SALMONELLA TYPHIMURIUM; TETRADECANOYLPHORBOL ACETATE;

ANIMALIA; BACTERIA (MICROORGANISMS); BOVINAE; SALMONELLA TYPHIMURIUM; TYPHIMURIUM;

EID: 0029671180     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(95)04032-3     Document Type: Article

References (13)

1. Bradford, M.M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing protein-dye binding. Anal. Biochem., 72, 248-254.
2. Epstein, J.H. (1977) Effects of β-carotene on ultraviolet-induced cancer formation in the hairless mouse skin. J. Photochem. Photobiol., 25, 211-213.
3. Kune, G.A., Kune, S., Field, B., Watson, L.F., Cleland, H., Merenstein, D. and Vitetta, L. (1993) Oral and pharyngeal cancer. Diet, smoking, alcohol and serum vitamin A and β-carotene level: a case-control study in men. Nutr. Cancer, 20, 61-70.
4. Matthews-Roth, M.M. (1982) Antitumor activity of β-carotene, canthaxanthin and phytoene. Oncology, 39, 33-37.
5. Mathews-Roth, M.M. and Krinsky, N.I. (1988) Carotenoid dose level and protection against UV-B-induced skin tumors. J. Photochem. Photobiol., 42, 35-38.
6. Moon, R.C. (1989) Comparative aspects of carotenoids and retinoids as chemopreventive agents for cancer. J. Nutr., 119, 127-134.
7. Murakoshi, M., Nishino, H., Satomi, Y., Takayasu, J., Hasegawa, T., Tokuda, H., Iwashima, A., Okuzumi, J., Okabe, H., Kitano, H. and Iwasaki, R. (1992) Potent preventive action of α-carotene against carcinogenesis: spontaneous liver carcinogenesis and promoting stage of lung and skin carcinogenesis in mice are suppressed more effectively by α-carotene than β-carotene. Cancer Res., 52, 6583-6587.
8. Okai, Y. (1984) 3T3 fibroblasts release a low-molecular-weight inhibitory peptide of lymphocyte DNA synthesis into serum-free culture medium. Biochim. Biophys. Acta, 802, 287-291.
9. Okai, Y., Higashi-Okai, K. and Nakamura, S. (1993) Identification of heterogenous antimutagenic activities in the extract of edible brown seaweeds, Laminaria japonica (Makonbu) and Undaria pinnatifida (Wakame) by umu gene expression system in Salmonella typhimurium (TA 1535/pSK 1002). Mutat. Res., 302, 63-70.
10. Okai, Y., Higashi-Okai, K., Nakamura, S., Yano, Y. and Otani, S. (1994) Suppressive effects of the extracts of Japanese edible seaweeds on mutagen-induced umu C gene expression in Salmonella typhimurium (TA 1535/pSK 1002) and tumor promoter-dependent ornithine decarboxylase induction in BALB/c 3T3 fibroblast cells. Cancer Lett., 87, 25-32.
11. Peto, R., Doll, R., Buckley, J.D. and Sporn, M.B. (1981) Can dietary beta-carotene materially reduce human cancer rate? Nature, 290, 201-208.
12. The α-Tocopherol, β-Carotene Cancer Prevention Study Group (1994) The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N. Engl. J. Med., 330, 1031-1035.
13. Willet, W.C. (1994) Diet and health: what should we eat? Science, 264, 532-537.