α2u-globulins in the urine of male rats: A reliable indicator for α2u-globulin accumulation in the kidney

Toxicology

Volumn 106, Issue 1-3, 1996, Pages 149-157

  Saito, Koichi ^a   Uwagawa, Satoshi ^a   Kaneko, Hideo ^a   Shiba, Kunio ^a   Tomigahara, Yoshitaka ^a   Nakatsuka, Iwao ^a  

^a SUMITOMO CHEMICAL CO LTD   (Japan)

Author keywords

Hyaline droplet; Indicator; Nephrotoxicity; 2u globulin; 2u globulin nephropathy

Indexed keywords

1,4 DICHLOROBENZENE; ALPHA 2U GLOBULIN; BIOLOGICAL MARKER; DECALIN; HEXACHLOROBUTADIENE; ISOPHORONE; LIMONENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; KIDNEY DISEASE; KIDNEY EPITHELIUM; MALE; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; URINARY EXCRETION; URINE;

ADMINISTRATION, ORAL; ALPHA-GLOBULINS; AMINO ACID SEQUENCE; ANIMALS; ANTI-BACTERIAL AGENTS; BUTADIENES; CARCINOGENS; CYCLOHEXENES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, POLYACRYLAMIDE GEL; KIDNEY; KIDNEY DISEASES; KIDNEY TUBULES, PROXIMAL; MALE; MOLECULAR SEQUENCE DATA; PUROMYCIN; RATS; RATS, SPRAGUE-DAWLEY; TERPENES;

ANIMALIA;

EID: 0029671173     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/0300-483X(95)03176-G     Document Type: Article

References (21)

1. 2u-globulin through the hepatic endoplasmic reticulum and Golgi apparatus during secretion. Biochim. Biophys. Acta 521, 333-341.
2. 2u-globulin in dichlorobenzene-induced nephrotoxicity. Toxicol. Appl. Pharmacol. 99, 122-132.
3. Feldeman, J.D. and Fisher, E.R. (1959) Renal lesions of aminonucleoside nephrosis as revealed by electron microscopy. Lab. Invest. 8, 371-378.
4. Ishmael, J., Pratt, I. and Lock, E. A. (1982) Necrosis of the pars recta (S3 segment) of the rat kidney produced by hexachloro 1:3 butadiene, J. Pathol. 138, 99-113.
5. Kanerva, R.L., Ridder, G.M., Stone, L.C. and Alden, C.L. (1987a) Characterization of spontaneous and decalininduced hyaline droplets in kidneys of adult male rats. Food Chem. Toxicol. 25, 63-83.
6. Kanerva, R.L., Ridder, G.M., Lefever, F.R. and Alden, C.L. (1987b) Comparison of the short-term renal effects due to oral administration of decalin or d-limonene in young adult male Fischer-344 rats. Food Chem. Toxicol. 25, 345-353.
7. Laemmli, U.K. (1970) Cleavage of structural proteins during assembly of the head of bacteriophage T4. Nature (Lond.) 227, 680-685.
8. 2u-globulin. Toxicol. Appl. Pharmacol. 99, 250-259.
9. 2u-globulin. Toxicol. Appl. Pharmacol. 91, 182-192.
10. 2u-globulin. Proc. Soc. Exp. Biol. Med. 182, 531-539.
11. 2u-globulin. Kidney Int. 16, 409-415.
12. 2u-globulin and albumin by adult male rats following treatment with nephrotoxic agents. Nephron 28, 133-140.
13. 2u-globulin in the hepatic and renal tissues of rat. J. Histochem. Cytochem. 20, 89-96.
14. 2u-globulin in the urine as a marker of d-limonene nephropathy. Toxicology 70, 173-183.
15. 2u-globulin. Toxicology 76, 177-186.
16. 2u-Globulin: measurement in rat kidney following administration of 2,2,4-trimethylpentane. Toxicology 41, 161-168.
17. Stonard, M.D., Gore, C.W., Oliver, G.J.A. and Smith, I.K. (1987) Urinary enzymes and protein patterns as indicators of injury to different regions of the kidney. Fundam. Appl. Toxicol. 9, 339-351.
18. Strasser, J. Jr., Charbonneau, M., Borghoff, S., Turner, M.J. and Swenberg, J.A. (1988) Renal protein droplet formation in male Fischer-344 rats after isophorone (IPH) treatment. Toxicologist 8, 136.
19. 2u-globulin nephropathy. Toxicol. Appl. Pharmacol. 97, 35-46.
20. 2u-globulin cDNAs. Proc. Natl. Acad. Sci. USA, 78, 3478-3482.
21. 2u-globulin nephropathy. J. Toxicol. Pathol. 5, 195-203.