Transforming growth factor-β2 increases NMDA receptor-mediated excitotoxicity in rat cerebral cortical neurons independently of glia

Neuroscience Letters

Volumn 204, Issue 1-2, 1996, Pages 93-96

  Kane, Cynthia J M ^a   Brown, Ginger J ^a   Phelan, Kevin D ^a  

^a UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Cerebral cortex; Excitotoxicity; Glia; Glutamate; N Methyl D aspartate receptors; Neurotoxicity; Transforming growth factor beta

Indexed keywords

EXCITOTOXIN; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; TRANSFORMING GROWTH FACTOR BETA2;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; EMBRYO; GLIA; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT;

2-AMINO-5-PHOSPHONOVALERATE; ANIMALS; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CEREBRAL CORTEX; EXCITATORY AMINO ACID AGONISTS; EXCITATORY AMINO ACID ANTAGONISTS; EXCITATORY AMINO ACIDS; FEMALE; N-METHYLASPARTATE; NEUROGLIA; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, N-METHYL-D-ASPARTATE; TRANSFORMING GROWTH FACTOR BETA;

EID: 0029670982     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12332-6     Document Type: Article

References (20)

1. Brewer, G.J. and Cotman, C.W., Survival and growth of hippocampal neurons in defined medium at low density: advantages of a sandwich culture technique or low oxygen, Brain Res., 494 (1989) 65-74.
2. Chao, C.C., Hu, S., Tsang, M., Weatherbee, J., Molitor, T.W., Anderson, W.R. and Peterson, P.K., Effects of transforming growth factor-β on murine astrocyte glutamine synthetase activity, J. Clin. Invest., 90 (1992) 1786-1793.
3. Choi, D.W., Glutamate neurotoxicity in cortical cell culture is calcium dependent, Neurosci. Lett., 58 (1985) 293-297.
4. Choi, D.W., Koh, J.Y. and Peters, S., Pharmacology of glutamate neurotoxicity in cortical cell culture: attentuation by NMDA antagonists, J. Neurosci., 8 (1988) 185-196.
5. Constam, D.B., Schmid, P., Aguzzi, A., Schachner, M. and Fontana, A., Transient production of TGF-β2 by postnatal cerebellar neurons and its effect on neuroblast proliferation, Eur. J. Neurosci., 6 (1994) 766-778.
6. Finch, C.E., Laping, N.J., Morgan, T.E., Nichols, N.R. and Painetti, G.M., TGF-β1 is an organizer of responses to neurodegeneration, J. Cell. Biochem., 53 (1993) 314-322.
7. Flanders, K.C., Lüdecke, G., Engels, S., Cissel, D.S., Roberts, A.B., Kondaiah, P., Lafyatis, R., Sporn, M.B. and Unsicker, K., Localization and actions of transforming growth factor-βs in the embryonic nervous system, Development, 113 (1991) 183-191.
8. Ishihara, A., Saito, H. and Abe, K., Transforming growth factor-β1 and -β2 promote neurite sprouting and elongation of cultured rat hippocampal neurons, Brain Res., 639 (1994) 21-25.
9. Kane, C.J.M., Phelan, K.D. and Chang, J.Y., TGF-β2 delays the developmental decrease in fast transient A-current expression in cultured rat superior cervical ganglion neurons, Soc. Neurosci. Abstr., 20 (1994) 719.
10. Koh, J.Y. and Choi, D.W., Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay, J. Neurosci. Methods, 20 (1987) 83-90.
11. Krieglstein, K., Suter-Crazzolara, C., Fischer, W.H. and Unsicker, K., TGF-β superfamily members promote survival of midbrain dopaminergic neurons and protect them against MPP toxicity, EMBO J., 14 (1995) 736-742.
12. Legido, A., Reichlin, S., Dichter, M.A. and Buchhalter, J., Expression of somatostatin and GABA immunoreactivity in cultures of rat hippocampus, Peptides, 11 (1990) 103-109.
13. Mahanthappa, N.K. and Schwarting, G.A., Peptide growth factor control of olfactory neurogenesis and neuron survival in vitro: roles of EGF and TGF-βs, Neuron, 10 ( 1993) 293-305.
14. Monyer, H., Barnshev, N., Laurie, D.J., Sakmann, B. and Seeburg, P.H., Development and regional expression in the rat brain and functional properties of four NMDA receptors, Neuron, 12 (1994) 529-540.
15. Poulsen, K.T., Armanini, M.P., Klein, R.D., Hynes, M.A., Phillips, H.S. and Rosenthal, A., TGFβ2 and TGFβ3 are potent survival factors for midbrain dopaminergic neurons, Neuron, 13 (1994) 1245-1252.
16. Prehn, J.H.M., Backhauß, C. and Krieglstein, J., Transforming growth factor-β1 prevents glutamate neurotoxicity in rat neocortical cultures and protects mouse neocortex from ischemic injury in vivo, J. Cereb. Blood Flow Metab., 13 (1993) 521-525.
17. Prehn, J.H.M. and Krieglstein, J., Opposing effects of transforming growth factor-β1 on glutamate neurotoxicity, Neuroscience, 60 (1994) 7-10.
18. Prehn, J.H.M., Peruche, B., Unsicker, K. and Krieglstein, J., Isoform-specific effects of transforming growth factors-β on degeneration of primary neuronal cultures induced by cytotoxic hypoxia or glutamate, J. Neurochem., 60 (1993) 1665-1672.
19. Roberts, A.B. and Sporn, M.B., The transforming growth factors-β. In M.B. Sporn and A.B. Roberts (Eds.), Handbook of Experimental Pharmacology, Peptide Growth Factors and Their Receptors, Springer-Verlag, Heidelberg, 1990, pp. 419-472.
20. Uto, A., Dux, E. and Hossmann, K.A., Effect of serum on intracellular calcium homeostasis and survival of primary cortical and hippocampal CA1 neurons following brief glutamate treatment, Metab. Brain Dis., 9 (1994) 333-345.