Serotonin 5-HT3 receptor binding kinetics in the cortex of suicide victims are normal

Journal of Neural Transmission

Volumn 103, Issue 1-2, 1996, Pages 165-171

  Mann, J J ^a   Arango, V ^a   Henteleff, R A ^a   Lagattuta, T F ^a   Wong, D T ^a  

^a NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

Brain; Serotonin; Serotonin 5 ht3 receptor; Suicide

Indexed keywords

SEROTONIN; SEROTONIN 3 RECEPTOR; 1 METHYL 3 INDAZOLECARBOXYLIC ACID N TROPANYLAMIDE; 5 HYDROXYINDOLEACETIC ACID; DIAGNOSTIC AGENT; INDAZOLE DERIVATIVE; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; TROPANE DERIVATIVE; TRYPTOPHAN;

ADULT; ARTICLE; BINDING KINETICS; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN TISSUE; MALE; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DENSITY; SEROTONIN BRAIN LEVEL; SEROTONINERGIC SYSTEM; SUICIDE; TEMPORAL CORTEX; BRAIN CORTEX; BRAIN LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; KINETICS; METABOLISM; PHYSIOLOGY;

ADULT; BRAIN CHEMISTRY; CEREBRAL CORTEX; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; HUMANS; HYDROXYINDOLEACETIC ACID; INDAZOLES; KINETICS; MALE; RECEPTORS, SEROTONIN; SEROTONIN; SEROTONIN ANTAGONISTS; SUICIDE; TROPANES; TRYPTOPHAN;

EID: 0029670905     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01292625     Document Type: Article

References (20)

1. 3H]LY278584 binding sites in human brain. J Neurochem 60: 730-737
2. Apud JA (1993) The 5-HT3 receptor in mammalian brain: a new target for the development of psychotropic drugs. Neuropsychopharmacology 8: 117-130
3. 2 and β-adrenergic receptor binding sites in the brain of suicide victims. Arch Gen Psychiatry 47: 1038-1047
4. 3 recognition sites in human brain tissue using [3H]zacopride. J Pharm Pharmacol 40: 668
5. Costall B (1993) The breadth of action of the 5-HT3 receptor antagonists. Int Clin Psychopharm 8: 3-9
6. Gorwood P, Ades J, Feingold J (1994) Are genes coding for dopamine receptors implicated in alcoholism. Eur Psychiatry 9: 63-69
7. IC receptor number is increased in hippocampus of suicide victims [Abstract]. Soc Neurosci Abstr 18: 1598
8. Korpi ER, Kleinman J, Goodman SI, Phillips I, DeLisi LE, Linnoila M, Wyatt RJ (1986) Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims. Comparison in chronic schizophrenic patients with suicide as cause of death. Arch Gen Psychiatry 43: 594-600
9. Lagattuta TF, Henteleff RA, Arango V, et al (1992) Reduction in cortical serotonin transporter site number in suicide victims in the absence of altered levels of serotonin, its precursors or metabolite [Abstract]. Soc Neurosci Abstr 18: 1598
10. Lowry OH, Rosenbrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the folin phenol reagent. J Biol Chem 193: 265-275
11. Mann JJ, McBride PA, Brown RP, Linnoila M, Leon AC, DeMeo MD, Nieczkowski TA, Myers JE, Stanley M (1992) Relationship between central and peripheral serotonin indexes in depressed and suicidal psychiatric inpatients. Arch Gen Psychiatry 49(6): 442-446
12. Mann JJ, Underwood MD, Arango V (1995) Postmortem studies of suicide victims. In: Watson SJ (ed) Biology of schizophrenia and affective disorders. Raven Press, New York
13. Maricq AV, Peterson AS, Brake AJ, Myers RM, Julius D (1991) Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel. Science 254: 432-437
14. McPherson GA (1985) Analysis of radioligand binding experiments: a collection of computer programs for the IBM PC. J Pharmacol Meth 14: 213-228
15. Munson PJ, Rodbard D (1980) LIGAND: a versatile computerized approach for characterization of ligand-binding systems. Anal Biochem 107: 220-239
16. Nauta WJH (1961) Fibre degeneration following lesions of the amygdaloid complex in the monkey. J Anat 95: 515-531
17. Nink M, Salomon E, Coutinho M, Treese N, Bernhard G, Krause U, Beyer J, Lehnert H (1994) Corticotropin-releasing hormone (CRH) is a respiratory stimulant in humans: a comparative study of human and ovine CRH. Life Sei 54: 1793-1799
18. Pratt GD, Bowery NG, Kilpatrick GJ, Leslie RA, Barnes NM, Naylor RJ, Jones BJ, Nelson DR, Palacios JM, Slater P, et al (1990) Consensus meeting agrees distribution of 5-HT3 receptors in mammalian hindbrain. Trends Pharmacol Sei 11: 135-137
19. Webster M-T, Francis PT, Procter AW, Stratmann GC, Doshi R, Mann DMA, Bowen DM (1994) Postmortem brains reveal similar but not identical amyloid precursor protein-like immunoreactivity in Alzheimer compared with other dementias. Brain Res 644: 347-351
20. Whitlock DG, Nauta WJH (1965) Subcortical projections from the temporal neocortex in Macacca mulatta. J Comp Neurol 106: 183-212