Synergy between μ/δ-opioid receptors mediates adenosine release from spinal cord synaptosomes

European Journal of Pharmacology

Volumn 298, Issue 1, 1996, Pages 45-49

  Cahill, Catherine M ^a   White, Thomas D ^a   Sawynok, Jana ^a  

^a DALHOUSIE UNIVERSITY   (Canada)

Author keywords

Adenosine; Opioid; Spinal cord; Synergy

Indexed keywords

ADENOSINE; DELTA OPIATE RECEPTOR; ENDORPHIN; ENKEPHALIN; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; ENKEPHALIN[2,5 DEXTRO PENICILLAMINE]; MORPHICEPTIN, N ME PHE(3); MORPHICEPTIN, N-ME-PHE(3)-; MU OPIATE RECEPTOR; DELTA 1 OPIATE RECEPTOR; DELTA 1 OPIOID RECEPTOR AGONIST; DELTA 2 OPIATE RECEPTOR; DELTA 2 OPIOID RECEPTOR AGONIST; DELTORPHIN[2 DEXTRO ALANINE 4 CYSTEINE]; MORPHICEPTIN[3 (N METHYLPHENYLALANINE) 4 DEXTRO PROLINAMIDE]; MORPHICEPTIN[3 (N METHYLPHENYLALANINE) 4 DEXTRO PROLINE]; MORPHINE; MU OPIATE RECEPTOR AGONIST; OPIATE AGONIST; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; DRUG POTENTIATION; MALE; PHYSIOLOGY; RAT; SECRETION; SPINAL CORD; SPRAGUE DAWLEY RAT; SYNAPTOSOME; ANIMAL TISSUE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DEPOLARIZATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PRIORITY JOURNAL;

ADENOSINE; ANIMALS; DRUG SYNERGISM; ENDORPHINS; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; ENKEPHALIN, D-PENICILLAMINE (2,5)-; ENKEPHALINS; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, DELTA; RECEPTORS, OPIOID, MU; SPINAL CORD; SYNAPTOSOMES;

EID: 0029670901     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(95)00775-X     Document Type: Article

References (33)

1. Barber, L.A. and M.R. Vasko, 1994, Activation of protein kinase C increases the release of neuropeptides from rat sensory neurons, Soc. Neurosci. Abstr. 20, 964.
2. Besse, D., M.C. Lombard and J.M. Bessen, 1991, Autoradiographic distribution of mu, delta and kappa opioid binding sites in the superficial dorsal horn, over the rostrocaudal axis of the rat spinal cord, Brain Res. 548, 287.
3. 2+ channels from dorsal spinal cord synaptosomes, Soc. Neurosci. Abstr. 18, 1371.
4. Cahill, C.M., T.D. White and J. Sawynok, 1993a, Involvement of calcium channels in depolarization-evoked release of adenosine from spinal cord synaptosomes, J. Neurochem. 60, 886.
5. 2+ channels to release adenosine from spinal cord synaptosomes, J. Neurochem. 60, 894.
6. Cahill, C.M., T.D. White and J. Sawynok, 1995, Spinal opioid receptors and adenosine release: neurochemical and behavioral characterization of subtypes, J. Pharmacol. Exp. Ther. (in press).
7. Chang, K.-J., E.T. Wei, A. Killian and J.-K. Chang, 1983, Potent morphiceptin analogs: structure-activity relationships and morphine-like activities, J. Pharmacol. Exp. Ther. 227, 403.
8. Cousins, M.J. and L.E. Mather, 1984, Intrathecal and epidural administration of opioids, Anesthesiology 61, 276.
9. DeLander, G.E., H.I. Mosberg and F. Porreca, 1992, Involvement of adenosine in antinociception produced by spinal or supraspinal receptor-selective opioid agonists: dissociation from gastrointestinal effects in mice, J. Pharmacol. Exp. Ther. 263, 1097.
10. Dickenson, A.H., 1993, Where and how do opioids act?, in: Proceedings of the 7th World Congress on Pain, eds. G.F. Gebhart, D.L. Hammond and T.S. Jensen (IASP Press) p. 525.
11. Erspamer, V., P. Melchiorri, G. Falconieri-Erspamer, L. Negri, R. Corsi, C. Severini, D. Barra, M. Simmaco and G. Kreil, 1989, Deltorphins: a family of naturally occurring peptides with a high affinity and selectivity for S opioid binding sites, Proc. Natl. Acad Sci. USA 86, 5188.
12. Fields, H.I., P.C. Einson, B.K. Keigh, R.F.T. Gilbert and L.L. Iverson, 1980, Multiple opioid receptor sites on primary afferent fibers, Nature 284, 351.
13. Goldstein, A., 1987, Binding selectivity profiles for ligands of multiple receptor types: focus on opioid receptors. Trends Pharmacol. Sci. 8, 456.
14. Heyman, J.S., Q. Jiang, R.B. Rothman, H.I. Mosberg and F. Porreca, 1989, Modulation of μ-mediated antinociception by δ opioid agonists: characterization with antagonists, Eur. J. Pharmacol. 169, 43.
15. James, I.F. and A. Goldstein, 1984, Site-directed alkylation of multiple opioid receptors, Mol. Pharmacol. 25, 337.
16. Jiang, Q., H.I. Mosberg and F. Porreca, 1990, Modulation of the potency and efficacy of μ-mediated antinociception by delta agonists in the mouse, J. Pharmacol. Exp. Ther. 254, 683.
17. Jin, W., N.M. Lee, H.H. Loh and S.A. Thayer, 1992, Dual excitatory and inhibitory effects of opioids on intracellular calcium in neuroblastoma × glioma hybrid NG108-15 cells, Mol. Pharmacol. 42, 1083.
18. Jin, W., N.M. Lee, H.H. Loh and S.A. Thayer, 1994, Opioids mobilize calcium from 1,4,5-trisphosphate-sensitive stores in NG108-15 cells, J. Neurosci. 14, 1920.
19. Malmberg, A.B. and T.L. Yaksh, 1992, Isobolographic and dose-response analysis of the interaction between intrathecal mu and delta agonists: effects of naltrindole and its benzofuran analog (NTB), J. Pharmacol. Exp. Ther. 263, 264.
20. Mattia, A., S.C. Farmer, A.E. Takemori, M. Sultana, P.S. Portoghese, H.I. Mosberg, W.D. Bowen and F. Porreca, 1992, Spinal opioid delta antinociception in the mouse: mediation by a single subtype of opioid delta receptor, J. Pharmacol. Exp. Ther. 260, 518.
21. Miaskowski, C., K.A. Sutters, Y.O. Taiwo and J.D. Levine, 1992, Antinociceptive and motor effects of delta/mu and kappa/mu combinations of intrathecal opioid agonists, Pain 49, 137.
22. Mosberg, H.I., R. Hurst, V.J. Hruby, K. Gee, H.I. Yamamura, J.J. Galligan and T.F. Burks, 1983, Bis-penicillamine enkephalins possess highly improved specificity towards δ opioid receptors, Proc. Natl. Acad. Sci. USA 80, 5871.
23. Porreca, F., A.E. Takemori, M. Sultana, P.S. Portoghese, W.D. Bowen and H.I. Mosberg, 1992, Modulation of mu-mediated antinociception in the mouse involves opioid delta-2 receptors, J. Pharmacol. Exp. Ther. 263, 147.
24. Sawynok, J. and M.I. Sweeney, 1989, The role of purines in nociception, Neuroscience 32, 557.
25. Shen, K.E. and S.M. Crain, 1989, Dual opioid modulation of the action potential duration of mouse dorsal root ganglion neurons in culture. Brain Res. 491, 227.
26. Smart, D., G. Smith and D.G. Lambert, 1994, μ-Opioid receptor stimulation of inositol (1,4,5)trisphosphatate formation via a pertussis toxin-sensitive G protein, J. Neurochem. 62, 1009.
27. Solomon, R.E. and G.F. Gebhart, 1994, Synergistic antinociceptive interactions among drugs administered to the spinal cord, Anesth. Analg. 78, 1164.
28. Stevens, C.W., C.B. Lacey, K.E. Miller, R.P. Elde and V.S. Seybold, 1991, Biochemical characterization and regional quantification of mu, delta and kappa opioid binding sites in rat spinal cord, Brain Res. 550, 77.
29. Sutters, K.A., C. Miaskowski, Y.O. Taiwo and J.D. Levine, 1990, Analgesic synergy and improved motor function produced by combinations of mu-delta and mu-kappa-opioids, Brain Res. 530, 290.
30. + release purines from capsaicin-sensitive primary afferent nerve terminals in the spinal cord, J. Pharmacol. Exp. Ther. 248, 447.
31. Traynor, J.R. and J. Elliot, 1993, δ-Opioid receptor subtypes and cross-talk with μ-receptors. Trends Pharmacol. Sci. 14, 84.
32. Wessinger, W.D., 1986, Approaches to the study of drug interactions in behavioral pharmacology, Neurosci. Biobehav. Rev. 10, 103.
33. Yaksh, T.L. and A.B. Malmberg, 1994, Central pharmacology of nociceptive transmission, in: Textbook of Pain, 3rd edn., eds. P.D. Wall and R. Melzack (Churchill Livingstone) p. 165.