Presence of neuropeptide Y Y1 receptor mediating vasoconstriction in human cerebral arteries

Neuroscience Letters

Volumn 204, Issue 3, 1996, Pages 145-148

  Nilsson, Torun ^a   Cantera, Leonor ^a   Edvinsson, Lars ^a  

^a LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

BIBP3226; Cerebral artery; Neuropeptide Y; NPY Y1; Polymerase chain reaction; Receptor; Reverse transcriptase

Indexed keywords

BORATE SODIUM; MESSENGER RNA; NALPHA (DIPHENYLACETYL) N (4 HYDROXYBENZYL) DEXTRO ARGININAMIDE; NEUROPEPTIDE Y; NEUROPEPTIDE Y [13-36]; NEUROPEPTIDE Y [34 PROLINE]; NEUROPEPTIDE Y RECEPTOR; NEUROPEPTIDE Y RECEPTOR ANTAGONIST; RECEPTOR SUBTYPE; RNA DIRECTED DNA POLYMERASE; UNCLASSIFIED DRUG; ARGININE; DRUG DERIVATIVE; NEUROPEPTIDE Y Y1 RECEPTOR; NEUROPEPTIDE Y-Y1 RECEPTOR; PRIMER DNA;

ARTICLE; BRAIN ARTERY; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; VASOCONSTRICTION; AGAR GEL ELECTROPHORESIS; CHEMISTRY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY;

ARGININE; BASE SEQUENCE; CEREBRAL ARTERIES; DNA PRIMERS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; HUMANS; MOLECULAR SEQUENCE DATA; NEUROPEPTIDE Y; POLYMERASE CHAIN REACTION; RECEPTORS, NEUROPEPTIDE Y; RNA, MESSENGER; VASOCONSTRICTION;

EID: 0029670702     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12315-6     Document Type: Article

References (20)

1. 1 antagonist BIBP3226, Br. J. Pharmacol., 116 (1995) 2245-2250.
2. Chomczynski, P. and Sacchi, N., Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal. Biochem., 162 (1987) 156-159.
3. Daughty, M.B., Chu, S.S., Miller, D.W., Li, K. and Tessel, R.E., Benextramine: a long lasting neuropeptide Y receptor antagonist, Eur. J. Pharmacol., 185 (1990) 113-114.
4. Edvinsson, L., Ekblad, E., Håkanson, R. and Wahlestedt, C., Neuropeptide Y potentiates the effect of various vasoconstrictor agents on rabbit blood vessels, Br. J. Pharmacol., 83 (1984) 519-525.
5. Edvinsson, L., Erlinge, D., Sun, X.Y. and Hedner, T., Neuropeptide Y in sympathetic co-transmission: recent advances in the search for neuropeptide Y antagonist, Pharmacol. Toxicol., 74 (1994) 193-201.
6. Erlinge, D., Brunkwall, J. and Edvinsson, L., Neuropeptide Y stimulates DNA synthesis in human vascular smooth muscle cells: cooperation with noradrenaline and ATP, Regul. Pept., 50 (1994) 259-265.
7. Erlinge, D., The sympathetic cotransmitters neuropeptide Y and ATP in the regulation of the vascular smooth muscle cell, Lund, 1994, pp. 51.
8. Fallgren, B., Ekblad, E. and Edvinsson, L., Co-existence of neuropeptides and differential inhibition of vasodilator responses by neuropeptide Y in guinea pig uterine arteries., Neurosci. Lett., 100 (1989) 71-76.
9. Fried, G., Terenius, L., Hökfelt, T. and Goldstein, M., Evidence for differential localization of noradrenaline and neuropeptide Y (NPY) in neuronal storage vesicles isolated from rat vas deference, J. Neurosci., 5 (1985) 450-458.
10. Grundemar, L. and Håkanson, R., Neuropeptide Y effector systems: perspective for drug development, Trends Pharmacol. Sci., 15 (1993) 153-159.
11. Grundemar, L., Mörner, J., Högestedt, E., Wahlestedt, C. and Håkansson, R., Characterization of vascular receptors for neuropeptide Y, Br. J. Pharmacol., 105 (1992) 45-50.
12. 1 receptor, J. Biol. Chem., 268 (1993) 6073.
13. Högestedt, E.D., Andersson, K.E. and Edvinsson, L., Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels, Acta Physiol. Scand., 117 (1983) 49-61.
14. 3 receptors, Eur. J. Pharmacol., 278 (1995) R3-R5.
15. 1 type, J. Biol. Chem., 267 (1992) 10935.
16. Linton-Dahlöf, P., Modulatory interactions of neuropeptide Y (NPY) on sympathetic neurotransmission, Acta Physiol. Scand., 137 (suppl. 586) (1989) 1-85.
17. Lundberg, J.M. and Tatemoto, K., Pancreatic polypeptide family (APP, BPP, NPY and PYY) in relation to sympathetic vasoconstriction resistant to α-adrenoceptor blockade, Acta Physiol. Scand., 116 (1982) 393-402.
18. Rudolf, H., Eberlein, W., Engel, W., Wieland, H.A., Willim, K.D., Entzeroth, M., Wienen, W., Beck-Sickinger, A.G. and Doods, H.N., The first highly potent and selective non-peptide neuropeptide Y Y1 receptor antagonist, Eur. J. Pharmacol., 271 (1994) 11-13.
19. 1 receptors for neuropeptide Y and PYY on vascular smooth muscle cells in rat pancreas, Am. J. Physiol., 260 (1991) G250.
20. 2 and receptor differentiation: a statistical analysis of competitive antagonism, Life Sci., 25 (1979) 637-654.