Stimulus-response characteristics of CO2-induced air hunger in normal subjects

Respiration Physiology

Volumn 103, Issue 1, 1996, Pages 19-31

  Banzett, Robert B ^a,b   Lansing, Robert W ^a,c   Evans, Karleyton C ^a   Shea, Steven A ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c University of Arizona   (United States)

Author keywords

Breath hold; Breathlessness; Control of breathing; Dyspnea; Mammals, humans; Sensation, respiratory, air hunger

Indexed keywords

CARBON DIOXIDE;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DYSPNEA; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERCAPNIA; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RESPIRATION CONTROL;

EID: 0029670599     PISSN: 00345687     EISSN: None     Source Type: Journal    
DOI: 10.1016/0034-5687(95)00050-X     Document Type: Article

References (24)

1. Adams, L., R. Lane, S.A. Shea, A. Cockcroft and A. Guz (1985). Breathlessness during different forms of ventilatory stimulation: a study of mechanisms in normal subjects and respiratory patients. Clin. Sci. 69: 663-672.
2. CO2 in mechanically ventilated quadriplegics. Respir. Physiol. 76: 53-67.
3. CO2 persists after complete neuromuscular block in humans. Respir. Physiol. 81: 1-17.
4. Bartlett, D., Jr. (1977). Effects of Valsalva and Mueller maneuvers on breath-holding time. J. Appl. Physiol. 42: 717-721.
5. Camacho, J., G. Farkas, P. Gay and R. Hubmayr (1993). Inspiratory muscle activity in mechanically ventilated humans. Am. Rev. Respir. Dis. 147: A701.
6. Chonan, T., M.B. Mulholland, M.D. Altose and N.S. Cherniack (1990a). Effects of changes in level and pattern of breathing on the sensation of dyspnea. J. Appl. Physiol. 69: 1290-1295.
7. Chonan, T., M.B. Mulholland, J. Leitner, M.D. Altose and N.S. Cherniack (1990b). Sensation of dyspnea during hypercapnia, exercise, and voluntary hyperventilation. J. Appl. Physiol. 68: 2100-2106.
8. 2 and in arterial pH. In: Handbook of Physiology, Section 3: The Respiratory System, Vol. II: Control of Breathing, part 2, edited by N.S. Cherniack and J.G. Widdicombe. Washington, DC: American Physiological Society, pp. 475-528.
9. Flume, P., F. Eldridge, L. Edwards and L. Houser (1994). The Fowler breathholding study revisited: continuous rating of respiratory sensation. Respir. Physiol. 95: 53-66.
10. Fowler, W.S. (1954). Breaking point of breath holding. J. Appl. Physiol. 6: 539-545.
11. Gandevia, S.C., K. Killian, D.K. McKenzie, M. Crawford, G.M. Allen, R.B. Gorman and J.P. Hales (1993). Respiratory sensations, cardiovascular control, kinaesthesia and transcranial stimulation during paralysis in humans. J. Physiol. (London) 470: 85-107.
12. Hill, L. and F. Flack (1908). The effect of excess of carbon dioxide and of want of oxygen upon the respiration and the circulation. J. Physiol. (London) 37: 77-111.
13. Hirshman, C., R. McCullough and J. Weil (1975). Normal values for hypoxic and hypercapnic ventilatory drives in man. J. Appl. Physiol. 38: 1095-1098.
14. Killian, K.J., S.C. Gandevia, E. Summers and E.J. Campbell (1984). Effect of increased lung volume on perception of breathlessness, effort, and tension. J. Appl. Physiol. 57: 686-691.
15. Lane, R., L. Adams and A. Guz (1990). The effects of hypoxia and hypercapnia on perceived breathlessness during exercise in humans. J. Physiol. (London) 428: 579-593.
16. CO2 in ventilated quadriplegics. Respir. Physiol. 90: 19-30.
17. Marshall, R., R. Stone and R. Christie (1954). The relationship of dyspnea to respiratory effort in normal subjects, mitral stenosis and emphysema. Clin. Sci. 13: 625-631.
18. Prechter, G.C., S.B. Nelson and R.D. Hubmayr (1990). The ventilatory recruitment threshold for carbon dioxide. Am. Rev. Respir. Dis. 141: 758-764.
19. Remmers, J.E., J. Brooks and S.M. Tenney (1968). Effect of controlled ventilation on the tolerable limit of hypercapnia. Respir. Physiol. 4: 78-90.
20. Schwartzstein, R.M., P.M. Simon, J.W. Weiss, V. Fencl and S.E. Weinberger (1989). Breathlessness induced by dissociation between ventilation and chemical drive. Am. Rev. Respir. Dis. 139: 1231-1237.
21. Simon, P.M., D.M. Griffin, D.M. Landry and J.B. Skatrud (1993). Inhibition of respiratory activity during passive ventilation: a role for intercostal afferents? Respir. Physiol. 92: 53-64.
22. Sternbach, R. (1978). Psychological dimensions and perceptual analyses, including pathologies of pain. In: Handbook of Perception, Vol. VI B: Feeling and Hurting, edited by E. Arteret and M. Friedman. New York: Academic Press, pp. 231-261.
23. Tuxen, D.V. (1994). Permissive hypercapnic ventilation. Am. J. Respir. Crit. Care Med. 150: 870-874.
24. Whitelaw, W., B. McBride, J. Amar and K. Corbet (1981). Respiratory neuromuscular output during breath holding. J. Appl. Physiol. 50: 435-443.