Controlled Release of Antibodies for Long-Term Topical Passive Immunoprotection of Female Mice Against Genital Herpes

Nature Biotechnology

Volumn 14, Issue 4, 1996, Pages 467-471

  Sherwood, Jill K ^a   Zeitlin, Larry ^a   Whaley, Kevin J ^a   Cone, Richard A ^a   Saltzman, Mark ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; ANTIBODY;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; INFECTION PREVENTION; INTRAVAGINAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PASSIVE IMMUNIZATION; PRIORITY JOURNAL; SUSTAINED RELEASE PREPARATION; IMMUNITY;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, VIRAL; BIOTECHNOLOGY; DELAYED-ACTION PREPARATIONS; DISEASE MODELS, ANIMAL; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; IMMUNIZATION, PASSIVE; IMMUNOGLOBULIN G; MEMBRANES, ARTIFICIAL; MICE; MICE, INBRED C57BL; TIME FACTORS;

ANIMALIA; HERPES; HUMAN HERPESVIRUS 2;

EID: 0029670578     PISSN: 10870156     EISSN: 15461696     Source Type: Journal    
DOI: 10.1038/nbt0496-468     Document Type: Article

References (22)

1. Division of STD/HIV Prevention. Annual Report 1994. U.S. Department of Health and Human Services, Public Health Service. Atlanta: Centers for Disease Control and Prevention. September 1995.
2. Koutsky, L. A., Stevens, C. E., Holmes, K. K., Ashley, R. L, Kiviat, N. B., Critchlow, C. W., and Corey, L. 1992. Underdiagnosis of genital herpes by current clinical and viral-isolation procedures. N. Engl. J. Med. 326:1533-1539.
3. Hook, E. W., Cannon, R. O., Nahmias, A. J., Lee, F. E, Campbell Jr., C. H., Glasser, D., and Quinn, T. C. 1992. Herpes simplex virus infection as a risk factor for human immunodeficiency virus infection in heterosexuals. J. Infect. Dis. 165:251-255.
4. Stone, K. M. 1994. HIV, other STDs, and barriers, pp. 203-212 in Barrier Contraceptives: Current Status and Future Prospects. Mauck, C, Cordero, M., Gabelnick, H., Spieler, J., and Rivera, R. (eds.). Wiley-Liss, New York.
5. Cohen, J. 1995. Women: absent term in the AIDS research equation. Science 269:777-780.
6. S. Para, M. F., Parish, M. L., Noble, A. G., and Spear, P. G. 1985. Potent neutralizing activity associated with anti-glycoprotein D specificity among monoclonal antibodies selected for binding to herpes simplex virions. J. Virol. 55:483-488.
7. Fuller, A. O. and Spear, P. G. 1987. Anti-glycoprotein D antibodies that permit adsorption but block infection by herpes simplex virus 1 prevent virion-cell fusion at the cell surface. Proc. Natl. Acad. Sci. USA 84:5454-5458.
8. Whaley, K. J., Zeitlin, L, Barratt, R. A., Hoen, T. E., and Cone, R. A. 1994. Passive immunization of the vagina protects mice against vaginal transmission of genital herpes infections. J. Infect. Dis. 169:647-649.
9. Sherwood, J. K., Zeitlin, L, Chen, X., Whaley, K. J., and Cone, R. A. 1996. Residence half-life of IgG administered topically to the mouse vagina. Biol. Reprod. 54:264-269.
10. Bias, C. J. and Heise, L. L 1994. Challenges for the development of female-controlled vaginal microbicides. AIDS 8:1-9.
11. Feldblum, P. and Joanis, C. 1994. Modern Barrier Methods: Effective Contraception and Disease Prevention. Family Health International, Research Triangle Park, NC.
12. Zador, G., Nilsson, B. A., Nilsson, B., Sjoberg, N. D., Westrom, L., and Wiese, J. 1976. Clinical experience with the uterine progesterone (Progestasert). Contraception 13:559-568.
13. Langer, R., Brem, H., and Tapper, D. 1981. Biocompatibility of polymeric delivery systems for macromolecules. J. Biomed. Mat. Res. 15:267-277.
14. Rhine, W. D., Hsieh, D. S. T, and Langer, R. 1980. Polymers for sustained macro-molecular release: procedures to fabricate reproducible delivery systems and control release kinetics. J. Pharm. Sci. 69:265-270.
15. Saltzman, W. M. and Langer, R. 1989. Transport rates of proteins in porous materials of known microgeometry. Biophys. J. 55:163-171.
16. Saltzman, W. M., Radomsky, M. L, Whaley, K. J. and Cone, R. A. 1994. Antibody diffusion in human cervical mucus. Biophys. J. 66:508-515.
17. Radomsky, M. L, Whaley, K. J., Cone, R. A., and Saltzman, W. M. 1992. Controlled vaginal delivery of antibodies in the mouse. Biol. Reprod. 47:133-140.
18. Siegel, R. A. and Langer, R. 1984. Controlled release of polypeptides and other macromolecules. Pharm. Res. 1:2-10.
19. Niruthisard, S., Roddy, R. E., and Chutivongse, S. 1991. The effects of frequent nonoxynol-9 use on the vaginal and cervical mucosa. Sex. Transm. Dis. 18:176-179.
20. Cone, R. A. and Whaley, K. J. 1994. Monoclonal antibodies for reproductive health: part I. preventing sexual transmission of disease and pregnancy with topically applied antibodies. Am. J. Reprod. Immunol. 32:114-131.
21. Whaley, K. J., Barratt, R. A., Zeitlin, L., Hoen, T. E., and Cone, R. A. 1993. Nonoxynol-9 protects mice against vaginal transmission of genital herpes infections. J. Infect. Dis. 168:1009-1011.
22. Snedecor, G. W. and Cochran, W. G. 1980. Statistical Methods, 7th ed. The Iowa State University Press, Iowa.