Relative Fasting Hypoinsulinaemia and Ultrasonically Measured Early Arterial Disease in Type 2 Diabetes

Diabetic Medicine

Volumn 13, Issue 3, 1996, Pages 247-253

  Elkeles, R S ^a   Diamond, J R ^a   El Bahghouti, N ^a   Dhanjil, S ^a   Nicolaides, A ^a   Geroulakos, G ^a   Renton, S ^a   Anyaoku, V ^a   Richmond, W ^a   Mather, H ^b   Sharp, P ^c  

^a ST MARY S HOSPITAL   (United Kingdom)

^b EALING HOSPITAL   (United Kingdom)

^c NORTHWICK PARK HOSPITAL   (United Kingdom)

Author keywords

Arterial ultrasonic score; Intima media thickness; Serum insulin; Type 2 diabetes

Indexed keywords

C PEPTIDE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LIPID;

ADULT; AGE; AGED; ARTERY DISEASE; ARTERY INTIMA PROLIFERATION; ARTICLE; CAROTID ARTERY; ECHOGRAPHY; FEMALE; FEMORAL ARTERY; HUMAN; HYPOINSULINEMIA; MAJOR CLINICAL STUDY; MALE; MULTIPLE REGRESSION; NON INSULIN DEPENDENT DIABETES MELLITUS;

EID: 0029670457     PISSN: 07423071     EISSN: None     Source Type: Journal    
DOI: 10.1002/(sici)1096-9136(199603)13:3<247::aid-dia28>3.0.co;2-x     Document Type: Article

References (32)

1. Pyorala K, Laakso M. Macrovascular disease in diabetes. In: Mann J, Pyorala K, Teuscher A, eds. Diabetes in Epidemiological Perspective. Edinburgh: Churchill Livingstone, 1983: 183-247.
2. Kannel WB, McCee DL. Diabetes and cardiovascular risk factors: The Framingham Study. Circulation 1979; 59: 8-13.
3. Janka HU. Five year incidence of major macrovascular complications in diabetes mellitus. Horm Metab Res 1985; 15 (suppl): 15-19.
4. Uusituppa MIJ, Niskanen LK, Siitonen O, Voutilainen E, Pyorala K. 5-year incidence of atherosclerotic vascular disease in relation to general risk factors, insulin level, and abnormalities in lipoprotein composition in non-insulin dependent diabetic and non-diabetic subjects. Circulation 1990; 82: 27-36.
5. Uusitupa MIJ, Niskanen LK, Siitonen O, Voutilainen E, Pyorala K. Ten-year incidence of cardiovascular mortality in relation to risk factors and abnormalities in lipoprotein composition in Type 2 diabetic and non-diabetic subjects. Diabetologia 1993; 36: 1175-1184.
6. Seviour PW, Teal TK, Richmond W, Elkeles RS. Serum lipids, lipoproteins and macrovascular disease in non-insulin dependent diabetics: a possible new approach to prevention. Diabetic Med 1988; 5: 166-171.
7. Fontbonne A, Charles MA, Thibult N, Richard JL, Claude JR, Warnet JM, et al. Hyperinsulinaemia as a predictor of coronary heart disease in a healthy population. The Paris Prospective Study, 15 year follow-up. Diabetologia 1991; 34: 356-361.
8. Ronnemaa T, Laakso M, Pyorala K, Kallio V, Puukka P. High fasting plasma insulin is an indicator of coronary heart disease in non-insulin dependent diabetic patients and non-diabetic subjects. Arterioscl and Thromb 1991; 11: 80-90.
9. Salonen JT, Salonen R. Ultrasound B-mode imaging in observational studies of atherosclerotic progression. Circulation 1993; 87 (suppl 11): 56-65.
10. Poli A, Tremoli E, Colombo A, Sirtori M, Pignoli P, Paoletti R. Ultrasonographic measurements of the common carotid artery wall thickness in hypercholesterolaemic patients: a new model for the quantitation and follow-up of preclinical atherosclerosis in living human subjects. Atherosclerosis 11988; 70: 253-61.
11. Belcaro C, Barsotti A, Nicolaides AN. Ultrasonic biopsy: A non-invasive screening technique to evaluate the cardiovascular risk and to follow up the progression and the regression of arteriosclerosis. Vasa 1991; 20: 40-50.
12. Belcaro G, Geroulakos G, Laudora G, Cesarone MR, De Sanctis MT, Incandela, I, et al. Inter/intraobserver variability of carotid and femoral bifuraction intima-media thickness measurements. Panminerva Med 1993; 35: 75-79.
13. Garg A, Grundy S. Management of dyslipidaemia in NIDDM. Diabetes Care 1990; 13: 153-169.
14. Havel RJ, Rapaport E. Management of primary hyperlipidaemia. New Engl J Med 1995; 332: 1491-1498.
15. Hampton SM, Morgan LM, Tredger JA, Cramb R, Marks V. Insulin and C-peptide levels after oral and intravenous glucose. Diabetes 1986; 35: 612-616.
16. Pignoli P, Tremoli E, Poli A, Oreste P, Paoletti R. Intima plus medial thickness of the arterial wall: a direct measurement with ultrasound imaging. Circulation 1986; 74: 1399-1406.
17. 7. Geroulakos G, O'Gorman DJ, Kalodiki E, Sheridan DJ, Nicolaides A. The intima media thickness as a marker of the presence of severe symptomatic coronary artery disease. Europ Heart J 1994; 15: 781-785.
18. Geroulakos G, O'Gorman D, Nicolaides A, Sheridan D, Elkeles R, Shaper AG. Carotid intima-media thickness: correlation with the British Regional Heart Study risk score. J Int Med 1994; 235: 431-433.
19. Kawamori R, Yamasaki Y, Matsushima H, Nishizawa H, Nao K, Hougaku H, et al. Prevalence of carotid atherosclerosis in diabetic patients. Diabetes Care 1992; 15: 1290-1294.
20. Geroulakos G, Ramaswami G, Veller MG, Fisher GM, Renton S, Nicolaides A, et al. Arterial wall changes in Type 2 diabetic subjects. Diabetic Med 1994; 11: 692-695.
21. Welborn TA, Wearne K. Coronary heart disease incidence and cardiovascular mortality in Busselton with reference to glucose and insulin concentration. Diabetes 1979; 2: 154-160.
22. Pyorala K, Savolainen E, Kaukola S, Haapakoski J. Plasma insulin as coronary heart disease risk factor: relation to other risk factors and predictive value during 9 year follow-up of the Helsinki Policeman Study population. Acta Med Scand 1985; 701 suppl: 38-52.
23. Fontbonne A, Eschwege E, Cambien F, Richard J, Ducimetiere P, Thibult N, et al. Hyperinsulinaemia as a risk factor of coronary heart disease mortality in subjects with impaired glucose tolerance or diabetes. Results from 11 year follow-up of the Paris Prospective Study. Diabetologia 1989; 32: 300-304.
24. Welin L, Eriksson H, Larsson B, Ohlson L-O, Svardsudd K, Tibblin G. Hyperinsulinaemia is not a major coronary risk factor in elderly men. Diabetologia 1992; 35: 766-770.
25. Jarrett RJ, McCartney P, Keen H. The Bedford Survey: Ten year mortality rate in newly diagnosed diabetics, borderline diabetics and normoglycaemic controls and risk indices for coronary heart disease in borderline diabetics. Diabetologia 1982; 22: 79-84.
26. Jarrett RJ. Why insulin is not a risk factor for coronary disease. Diabetologia 1994; 37: 945-947.
27. Durrington PN. Is insulin atherogenic? Diabetic Med 1992; 9: 597-600.
28. Davies MJ, Metcalfe J, Gray IP, Day JL, Hales CN. Insulin deficiency rather than hyperinsulinaemia in newly diagnosed Type 2 diabetes. Diabetic Med 1993; 10: 305-312.
29. Faber OK, Binder C. C-peptide response to glucagon. A test for residual B-cell function in diabetes mellitus. Diabetes 1977; 26: 6050-610.
30. Hovorka R, Jones RH. How to measure insulin secretion. Diabetes and Metabolism Reviews 1994; 10: 91-117.
31. Ledet T, Heickendorff L, Rasmussen LM. Pathology of macrovascular disease. In: Nattrass M, Hale PJ, eds. Clinical Endocrinology and Metabolism: Non-Insulin-Dependent Diabetes, Vol. 2. London: Baillière Tindall, 1988: 391-405.
32. Heickendorff L, Ledet T, Rasmussen LM. Glycosaminoglycans in the human aorta in diabetes mellitus: a study of tunica media from areas with and without atherosclerotic plaque. Diabetologia 1994; 37: 286-292.