A benzothiophene-carboxamide is a potent inhibitor of IL-1β induced VCAM-1 gene expression in human endothelial cells

FEBS Letters

Volumn 382, Issue 3, 1996, Pages 323-326

  Cobb, Ronald R ^a   Felts, Katherine A ^a   McKenzie, Thomas C ^a   Parry, Graham C N ^b   Mackman, Nigel ^b  

^a Tanabe Research Laboratories   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Benzothiophene carboxamide; Inhibition; Nuclear factor B; Transcription; VCAM 1

Indexed keywords

BENZOTHIOPHENE DERIVATIVE; BETA ACTIN; CELL ADHESION MOLECULE; INTERLEUKIN 1BETA; MESSENGER RNA; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; TRANSCRIPTION FACTOR; VASCULAR CELL ADHESION MOLECULE 1; 3 ISOPROPOXY 5 METHOXYBENZO(B)THIOPHENE 2 CARBOXAMIDE; 3-ISOPROPOXY-5-METHOXYBENZO(B)THIOPHENE-2-CARBOXAMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; THIOPHENE DERIVATIVE;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; NORMAL HUMAN; PRIORITY JOURNAL; UMBILICAL VEIN; VASCULAR ENDOTHELIUM; CELL CULTURE; CELL NUCLEUS; CYTOLOGY; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROMOTER REGION; SYNTHESIS; TRANSPORT AT THE CELLULAR LEVEL;

BASE SEQUENCE; BIOLOGICAL TRANSPORT; CELL NUCLEUS; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-1; MOLECULAR SEQUENCE DATA; NF-KAPPA B; PROMOTER REGIONS (GENETICS); RNA, MESSENGER; THIOPHENES; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; UMBILICAL VEINS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0029670423     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-5793(96)00202-5     Document Type: Article

References (24)

1. Springer, T.A. (1994) Cell 76, 301-314.
2. Osborn, L., Hession, C., Tizard, R., Vassallo, C., Luhowskyj, S., Chi-Rosso, G. and Lobb, R. (1989) Cell 59, 1203-1211.
3. Elices, M.J., Osborn, L., Takada, Y., Crouse, C., Luhowskyj, S., Hemler, M.E. and Lobb, R. (1990) Cell 60, 577-584.
4. Iademarco, M.F., McQuillan, J.J., Rosen, G.D. and Dean, D.C. (1992) J. Biol. Chem. 267, 16323-16329.
5. Neish, A.S., Williams, A.J., Palmer, H.J., Whitley, M.Z. and Collins, T. (1992) J. Exp. Med. 176, 1583-1593.
6. Lenardo, M.J. and Baltimore, D. (1989) Cell 58, 227-229.
7. Kawakami, K., Scheidereit, C. and Roeder, R.G. (1988) Proc. Natl. Acad. Sci. USA 85, 4700-4704.
8. Lenardo, M.J., Kuang, A., Gifford, A. and Baltimore, D. (1988) Proc. Natl. Acad. Sci. USA 85, 8825-8829.
9. Ghosh, S., Gifford, A.M., Riviere, L.R., Tempst, P., Nolan, G.P. and Baltimore, D. (1990) Cell 62, 1019-1029.
10. Baeuerle, P. and Baltimore, D. (1988) Science 242, 540-546.
11. Kieran, M., Blank, V., Logeat, F., Vandederckhove, J., Lottspeich, F., LeBail, O., Urban, M., Kourilsky, P., Baeuerle, P.A. and Israel, A. (1990) Cell 62, 1007-1028.
12. Ruben, S.M., Dillon, P.J., Schreck, R., Henkel, T., Chen, C.H., Maaher, M., Baeuerle, P.A. and Rosen, C.A. (1991) Science 251, 1490-1493.
13. Beg, A.A., Finco, T.S., Nantermet, P.V. and Baldwin, A.S., Jr. (1993) Mol. Cell. Biol. 13, 3301-3310.
14. Henkel, T., Machleidt, T., Alkaly, I., Kronke, M., Ben-Neriah, Y. and Baeuerle, P.A. (1993) Nature 365, 182-185.
15. Baeuerle, P.A. and Baltimore, D. (1988) Cell 53, 211-217.
16. Traenckner, E.B.-M., Wilk, S. and Baeuerle, P.A. (1994) EMBO J. 13, 5433-5441.
17. Finco, T.S., Beg, A.A. and Baldwin, A.S., Jr. (1994) Proc. Natl. Acad. Sci. USA 91, 11884-11888.
18. Boschelli, D.H., Kramer, J.B., Connor, D.T., Lesch, M.E., Schrier, D.J., Ferin, M.A. and Wright, C.D. (1994) J. Med. Chem. 37, 717-718.
19. Cobb, R.R., Martin, J., Korytynski, E., Monteith, L. and Hughes, T.J. (1989) Mutat. Res. 226, 253-258.
20. Maniatis, T., Fritsch, E.F. and Sambrook, J. (1982) Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory, NY.
21. Parry, G.C.N. and Mackman, N. (1994) J. Biol. Chem. 269, 20823-20825.
22. Deescheemaeker, K.A., Wyns, S., Nelles, L., Auwerz, J., Ny, T. and Collen, D. (1992) J. Biol. Chem. 267, 15086-15091.
23. Stuhlmeir, K.M., Csizmadia, V., Cheng, Q., Winkler, H. and Bach, F.H. (1994) Eur. J. Immunol. 24, 2186-2190.
24. Neish, A.S., Read, M.A., Thanos, D., Pine, R., Maniatis, T. and Collins, T. (1995) Mol. Cell. Biol. 15, 2558-2569.