Expression of Ca2+/calmodulin-dependent protein kinase types II and IV, and reduced DNA synthesis due to the Ca2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine) in small cell lung carcinoma

Biochemical Pharmacology

Volumn 51, Issue 5, 1996, Pages 707-715

  Williams, Carol L ^a   Phelps, Scott H ^a   Porter, Rebecca A ^a  

^a GUTHRIE RESEARCH INSTITUTE   (United States)

Author keywords

Ca2+ calmodulin dependent protein kinase; Cell cycle; Cell proliferation; DNA synthesis; KN 62; Small cell lung carcinoma

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 1 [N,O BIS(5 ISOQUINOLINESULFONYL) N METHYLTYROSYL] 4 PHENYLPIPERAZINE; CALCIUM; CALMODULIN DEPENDENT PROTEIN KINASE II; CALMODULIN DEPENDENT PROTEIN KINASE IV; CALMODULIN-DEPENDENT PROTEIN KINASE II; CALMODULIN-DEPENDENT PROTEIN KINASE IV; DNA; DRUG DERIVATIVE; ENZYME INHIBITOR; ISOQUINOLINE DERIVATIVE; PIPERAZINE DERIVATIVE; PROTEIN KINASE (CALCIUM,CALMODULIN); CALCIUM CHANNEL; ENZYME ANTIBODY; ISOENZYME; PROTEIN KINASE INHIBITOR;

ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DIVISION; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; LUNG TUMOR; METABOLISM; PATHOLOGY; PHYSIOLOGY; SMALL CELL CARCINOMA; AUTOPHOSPHORYLATION; CALCIUM TRANSPORT; CANCER CELL CULTURE; CELL CYCLE; CELL CYCLE S PHASE; CELL STRAIN K 562; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME SUBUNIT; HUMAN CELL; IMMUNOPRECIPITATION; LUNG SMALL CELL CANCER; NEUROBLASTOMA CELL; PRIORITY JOURNAL; REGULATORY MECHANISM;

1-(5-ISOQUINOLINESULFONYL)-2-METHYLPIPERAZINE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CALCIUM; CARCINOMA, SMALL CELL; CELL DIVISION; DNA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; ISOQUINOLINES; LUNG NEOPLASMS; PIPERAZINES; TUMOR CELLS, CULTURED;

EID: 0029670380     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(95)02393-3     Document Type: Article

References (50)

1. Poenie M, Alderton J, Tsien RY and Steinhardt RA, Changes of free calcium levels with stages of the cell division cycle. Nature 315: 147-149, 1985.
2. Whitaker M and Patel R, Calcium and the cell cycle. Development 108: 525-542, 1990.
3. Berridge MJ, Inositol triphosphate and calcium signalling. Nature 361: 315-325, 1993.
4. 2+ in Saccharomyces cerevisiae. J Biol Chem 265: 21222-21226, 1990.
5. 2+/calmodulin-dependent protein kinase is necessary for nuclear envelope breakdown. J Cell Biol 111: 1763-1773, 1990.
6. 1 phase of the human WI-38 fibroblast. J Cell Physiol 104: 97-103, 1980.
7. Means AR, VanBerkum MFA, Bagchi I, Lu KP and Rasrnussen CD, Regulatory functions of calmodulin. Pharmacol Ther 50: 255-270, 1991.
8. Dawson RA and Mac Neil S, Mitogenic role for extracellular calmodulin-like activity in normal human umbilical vein endothelial cells. Br J Haematol 82: 151-160, 1992.
9. Rasmussen CD and Means AR, Calmodulin is involved in regulation of cell proliferation. EMBO J 6: 3961-3968, 1987.
10. 1 and mitosis. EMBO J 8: 73-82, 1989.
11. Lopez-Girona A, Colomer J, Pujol MJ, Bachs O and Agell N, Calmodulin regulates DNA polymerase a activity during proliferative activation of NRK cells. Biochem Biophys Res Commun 184: 1517-1523, 1992.
12. Reddy GPV, Reed WC, Deacon DH and Quesenberry PJ, Growth factor-dependent proliferative stimulation of hematopoietic cells is associated with the modulation of cytoplasmic and nuclear 63-Kd calmodulin-binding protein. Blood 79: 1946-1955, 1992.
13. Reddy GPV, Reed WC, Sheehan E and Sacks DB, Calmodulin-specific monoclonal antibodies inhibit DNA replication in mammalian cells. Biochemistry 31: 10426-10430, 1992.
14. 2+/calmodulin-dependent protein kinases. Curr Opin Cell Biol 5: 247-253, 1993.
15. 2+/ calmodulin-dependent protein kinase IV gene. FEBS Lett 289: 105-109, 1991.
16. 2+-calmodulin-dependent protein kinase and a male germ cell-specific calmodulin-binding protein are derived from the same gene. Mol Biol Cell 11: 3960-3971, 1991.
17. 2+/calmodulin-dependent protein kinase Gr and calspermin: A gene within a gene. Proc Natl Acad Sci USA 88: 5784-5788, 1991.
18. 2+/calmodulin-dependent protein kinase-Gr from human brain and thymus. Gene 142: 191-197, 1994-
19. 2+/calmodulin-dependent protein kinase enriched in cerebellar granule cells. Identification of a novel neuronal calmodulin-dependent protein kinase. J Biol Chem 264: 5866-5875, 1989.
20. 2+/calmodulin-dependent protein kinase type Gr in rat cerebellar cortex. Proc Natl Acad Sci USA 88: 2850-2853, 1991.
21. Lorca T, Cruzalegul FH, Fesquet D, Cavadore J-C, Mery J, Means A and Doree M, Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs. Nature 366: 270-273, 1993.
22. 2+/calmodulin-dependent pro-tein kinase type IV. J Biol Chem 269: 15520-15527, 1994.
23. Matthews RP, Guthrie CR, Wailes LM, Zhao X, Means A and McKnight GS, Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol Cell Biol 14: 6107-6116, 1994.
24. 3 muscarinic acetylcholine receptors inhibits voltage-dependent calcium influx in small cell lung carcinoma. J Biol Chem 265: 1443-1447, 1990.
25. Wegner M, Cao Z and Rosenfeld MG, Calcium-regulated phosphorylation within the leucine zipper of C/EBPβ. Science 256: 370-373, 1992.
26. Ito I, Hidaka H and Sugiyama H, Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II on long-term potentiation in the rat hippocampus. Neurosci Lett 121: 119-121, 1991.
27. Tansey MG, Word RA, Hidaka H, Singer HA, Schworer CM, Kamm KE and Stull JT, Phosphorylation of myosin light chain kinase by the multifunctional calmodulin-dependent protein kinase II in smooth muscle cells. J Biol Chem 267: 12511-12516, 1992.
28. 2+/calmodulin-dependent protein kinase II. J Biol Chem 265: 4315-4320, 1990.
29. 2+-calmodulin-dependent protein kinase II inhibitor on GABA release in cerebrospinal fluid of the rat. J Pharmacol Exp Ther 254: 598-602, 1990.
30. 2+ channels. Mol Pharmacol 42: 489-498, 1992.
31. Ämmälä C, Eliasson L, Bokvist K, Larsson O, Ashcroft FM and Rorsman P, Exocytosis elicited by action potentials and voltage-clamp calcium currents in individual mouse pancreatic B-cells. J Physiol (Lond) 472: 665-688, 1993.
32. 2+/calmodulin-dependent protein kinase II. Biochem Biophys Res Commun 189: 128-133, 1992.
33. Williams CL and Lennon VA, Activation of muscarinic acetylcholine receptors inhibits cell cycle progression of small cell lung carcinoma. Mol Biol Cell 2: 373-381, 1991.
34. tylcholine receptors in small cell lung carcinoma. J Cell Biol 121: 643-654, 1993.
35. 2+/calmodulin-dependent protein kinases. Annu Rev Biochem 61: 559-601, 1992.
36. 2+/calmodulin-dependent protein kinase, CaM kinase-Gr, in human T lymphocytes. Regulation of kinase activity by T cell receptor signaling. J Biol Chem 268: 20055-20063, 1993.
37. Mangels LA and Gnegy ME, Carbachol stimulates binding of a photoreactive calmodulin derivative to calmodulin-binding proteins in intact SK-N-SH human neuroblastoma cells. J Biol Chem 267: 5847-5854, 1992.
38. Rutherford T, Clegg JB, Higgs DR, Jones RW, Thompson J and Weatherall DF, Embryonic erythroid differentiation in the human leukemic cell line K562. Proc Natl Acad Sci USA 78: 348-352, 1981.
39. 2+/ calmodulin-dependent protein kinase II inhibitor on cell cycle. Biochem Biophys Res Commun 199: 241-248, 1994.
40. 282 and multiple basic residues. J Biol Chem 267: 1761-1768, 1992.
41. 2+/calmodulin-dependent protein kinase and mutational analysis of its autoregulation. Neuron 3: 59-70, 1989.
42. 3 cells. J Biol Chem 266: 1484-1490, 1991.
43. 2+/ calmodulin-dependent kinase in intact hippocampal slices. Neuron 6: 907-914, 1991.
44. 2+/calmodulin-dependent protein kinase. J Biol Chem 267: 12197-12201, 1992.
45. 2+/calmodulin-dependent protein kinase inhibitor KN-62 (1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazine). Biochem Pharmacol 50: 1979-1985, 1995.
46. 2+/calmodulin-dependent protein kinase type "GR." J Biol Chem 268: 10054-10059, 1993.
47. 2+-channel blocker verapamil on human lung cancer cell lines. Carcinogenesis 12: 2301-2303, 1991.
48. 2+/calmodulin antagonists. Cancer Res 52: 2723s-2726s, 1992.
49. Mac Neil S, Dawson RA, Crocker G, Tucker WFG, Bittiner B, Singleton JG, Hunter T and Tierney DF, Antiproliferative effects on keratinocytes of a range of clinically used drugs with calmodulin antagonist activity. Br J Dermatol 128: 143-150, 1993.
50. Mannhold R and Timmerman H, Putative therapeutic applications of calmodulin antagonists. Pharm Weekbl [Sci] 14: 161-166, 1992.