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Volumn 64, Issue 2, 1996, Pages 151-161

Immunoregulatory effects of interferon-β and interacting cytokines on human vascular endothelial cells implications for multiple sclerosis and other autoimmune diseases

Author keywords

Adhesion molecules; Human vascular endothelial cells; Interferon ; Interferon ; Major histocompatibility complex; Tumor necrosis factor

Indexed keywords

BETA INTERFERON; GAMMA INTERFERON; HLA DR ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

EID: 0029670139     PISSN: 01655728     EISSN: None     Source Type: Journal    
DOI: 10.1016/0165-5728(95)00164-6     Document Type: Article
Times cited : (67)

References (47)
  • 3
    • 0023794099 scopus 로고
    • Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation of multiple sclerosis: Do cytokines trigger exacerbations?
    • Beck, J., Rondol, P., Catinol, L., Falcoff, E., Kirchner, H. and Weitzerbin, J. (1988) Increased production of interferon gamma and tumor necrosis factor precedes clinical manifestation of multiple sclerosis: do cytokines trigger exacerbations? Acta Neurol. Scand. 78, 318-323.
    • (1988) Acta Neurol. Scand. , vol.78 , pp. 318-323
    • Beck, J.1    Rondol, P.2    Catinol, L.3    Falcoff, E.4    Kirchner, H.5    Weitzerbin, J.6
  • 4
    • 0342401140 scopus 로고
    • Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblast
    • Collins, T., Korman, A.J., Wake, C.T., Boss, J.M., Kappesd, D.J., Fiers, W., Ault, K.A, Gimbrone, M.A., Strominger, J.L. and Pober, J.S. (1984) Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblast. Proc. Natl. Acad. Sci. USA 81, 4917-4921.
    • (1984) Proc. Natl. Acad. Sci. USA , vol.81 , pp. 4917-4921
    • Collins, T.1    Korman, A.J.2    Wake, C.T.3    Boss, J.M.4    Kappesd, D.J.5    Fiers, W.6    Ault, K.A.7    Gimbrone, M.A.8    Strominger, J.L.9    Pober, J.S.10
  • 5
    • 0039024457 scopus 로고
    • Inhibition of interferon-γ-induced MHC class II gene transcription by interferon-β and type b1 TGF in human astrocytoma cells
    • Devajyothi, C., Kalvakolanu, I., Babcock, G.T., Vasavada, H.A., Hower, P.H. and Ransohoff, R.M. (1993) Inhibition of interferon-γ-induced MHC class II gene transcription by interferon-β and type b1 TGF in human astrocytoma cells. J. Biol. Chem. 268, 18974-18800.
    • (1993) J. Biol. Chem. , vol.268 , pp. 18974-118800
    • Devajyothi, C.1    Kalvakolanu, I.2    Babcock, G.T.3    Vasavada, H.A.4    Hower, P.H.5    Ransohoff, R.M.6
  • 6
    • 0028963171 scopus 로고
    • Circulating soluble adhesion proteins in cerebrospinal fluid and serum of patients with multiple sclerosis: Correlation with clinical activity
    • Dore-Duffy, P., Newman, W., Balabanov, R., Lisak, R.P., Mainolfi, E., Rothlein, R. and Peterson, M. (1995) Circulating soluble adhesion proteins in cerebrospinal fluid and serum of patients with multiple sclerosis: correlation with clinical activity. Ann. Neurol. 37, 55-62.
    • (1995) Ann. Neurol. , vol.37 , pp. 55-62
    • Dore-Duffy, P.1    Newman, W.2    Balabanov, R.3    Lisak, R.P.4    Mainolfi, E.5    Rothlein, R.6    Peterson, M.7
  • 7
    • 0025037064 scopus 로고
    • IFN-gamma enhances endothelial activation induced by tumor necrosis factor but not IL-1
    • Doukas, J. and Pober, J.S. (1990) IFN-gamma enhances endothelial activation induced by tumor necrosis factor but not IL-1. J. Immunol. 145, 1727-1733.
    • (1990) J. Immunol. , vol.145 , pp. 1727-1733
    • Doukas, J.1    Pober, J.S.2
  • 8
    • 0027158422 scopus 로고
    • Regulation of MHC class I and beta 2-microglobulin gene expression in human neuronal cells. Factor binding to conserved cis-acting regulatory sequences correlated with expression of the genes
    • Drew, P.D., Lonergan, M., Goldstein, M.E., Lampson, L.A., Ozato, K. and McFarlin, D.E. (1993) Regulation of MHC class I and beta 2-microglobulin gene expression in human neuronal cells. Factor binding to conserved cis-acting regulatory sequences correlated with expression of the genes. J. Immunol. 150, 3300-3310.
    • (1993) J. Immunol. , vol.150 , pp. 3300-3310
    • Drew, P.D.1    Lonergan, M.2    Goldstein, M.E.3    Lampson, L.A.4    Ozato, K.5    McFarlin, D.E.6
  • 9
    • 0028308758 scopus 로고
    • Influx of leukocytes and platelets in an involving brain infarct (Wistar rat)
    • Garcia, J.H., Liu, R.F., Yoshida, Y., Lian, J., Chen, S. and del-Zoppo, G.L. (1994) Influx of leukocytes and platelets in an involving brain infarct (Wistar rat). Am. J. Pathol. 144, 188-199.
    • (1994) Am. J. Pathol. , vol.144 , pp. 188-199
    • Garcia, J.H.1    Liu, R.F.2    Yoshida, Y.3    Lian, J.4    Chen, S.5    Del-Zoppo, G.L.6
  • 10
    • 0027156071 scopus 로고
    • Regulation of the expression of ICAM-1 in cultured human endothelial cells derived from rheumatoid arthritis synovium
    • Gerritsen, M.E., Kelley, K.A., Ligon, G., Perry, C.A., Shen, C.-P., Szczepanski, A. and Carley, W.W. (1993) Regulation of the expression of ICAM-1 in cultured human endothelial cells derived from rheumatoid arthritis synovium. Arthr. Rheum. 36, 593-602.
    • (1993) Arthr. Rheum. , vol.36 , pp. 593-602
    • Gerritsen, M.E.1    Kelley, K.A.2    Ligon, G.3    Perry, C.A.4    Shen, C.-P.5    Szczepanski, A.6    Carley, W.W.7
  • 11
    • 0028075830 scopus 로고
    • Interleukin-6 signaling via four transcription factors binding palindromic enhancers of different genes
    • Harroch, S., Revel, M. and Chebath, J. (1994) Interleukin-6 signaling via four transcription factors binding palindromic enhancers of different genes. J. Biol. Chem. 269, 26191-26195.
    • (1994) J. Biol. Chem. , vol.269 , pp. 26191-26195
    • Harroch, S.1    Revel, M.2    Chebath, J.3
  • 13
    • 0024366885 scopus 로고
    • Tumor necrosis factor identified in multiple sclerosis brain
    • Hofman, F.M., Hinton, D.R., Johnson, K. and Merrill, J.E. (1989) Tumor necrosis factor identified in multiple sclerosis brain. J. Exp. Med. 170, 607-612.
    • (1989) J. Exp. Med. , vol.170 , pp. 607-612
    • Hofman, F.M.1    Hinton, D.R.2    Johnson, K.3    Merrill, J.E.4
  • 14
    • 0028093436 scopus 로고
    • Expression of the chemokine superfamily in rheumatoid arthritis
    • Hosaka, S., Akahoshi, T. and Wada, C. (1994) Expression of the chemokine superfamily in rheumatoid arthritis. Clin. Exp. Immunol. 97, 451-457.
    • (1994) Clin. Exp. Immunol. , vol.97 , pp. 451-457
    • Hosaka, S.1    Akahoshi, T.2    Wada, C.3
  • 15
    • 0022482909 scopus 로고
    • Contrasting effect of α/β- and γ-interferons on expression of macrophage 1a antigen
    • Inaba, K., Kitaura, M., Kato, T., Watanabe, Y., Kawade, Y. and Muramatsu, S. (1990) Contrasting effect of α/β- and γ-interferons on expression of macrophage 1a antigen. J. Exp. Med. 163, 1030-1035.
    • (1990) J. Exp. Med. , vol.163 , pp. 1030-1035
    • Inaba, K.1    Kitaura, M.2    Kato, T.3    Watanabe, Y.4    Kawade, Y.5    Muramatsu, S.6
  • 16
    • 0015822275 scopus 로고
    • Cultures of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria
    • Jaffe, E.A., Nachman, N.L., Becker, C.G. and Minick, C.R. (1973) Cultures of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52, 2745-2756.
    • (1973) J. Clin. Invest. , vol.52 , pp. 2745-2756
    • Jaffe, E.A.1    Nachman, N.L.2    Becker, C.G.3    Minick, C.R.4
  • 17
    • 0026516799 scopus 로고
    • Augmentation of major histocompatibility complex class I and ICAM-1 expression on glial cells following measles virus infection: Evidence for the role of type-1 interferon
    • Kraus, E., Schneider-Schaulies, S., Miyasaka, M., Tamatani, T. and Sedgwick, J. (1992) Augmentation of major histocompatibility complex class I and ICAM-1 expression on glial cells following measles virus infection: evidence for the role of type-1 interferon. Eur. J. Immunol. 22, 175-182.
    • (1992) Eur. J. Immunol. , vol.22 , pp. 175-182
    • Kraus, E.1    Schneider-Schaulies, S.2    Miyasaka, M.3    Tamatani, T.4    Sedgwick, J.5
  • 18
    • 0026063914 scopus 로고
    • Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both ELAM-1 and ICAM-1
    • Luscinskas, F.W., Cybulsky, M.I., Kiely, J.-M., Peckins, C.S., Davis, V.M. and Gimbrone, M.A. (1991) Cytokine-activated human endothelial monolayers support enhanced neutrophil transmigration via a mechanism involving both ELAM-1 and ICAM-1. J. Immunol. 146,1617-1625.
    • (1991) J. Immunol. , vol.146 , pp. 1617-1625
    • Luscinskas, F.W.1    Cybulsky, M.I.2    Kiely, J.-M.3    Peckins, C.S.4    Davis, V.M.5    Gimbrone, M.A.6
  • 19
    • 0026725537 scopus 로고
    • Cytokine regulation of endothelial cell function
    • Mantovani, A., Bussolino, F. and Dejana, E. (1992) Cytokine regulation of endothelial cell function. FASEB J. 6, 2591-2599.
    • (1992) FASEB J. , vol.6 , pp. 2591-2599
    • Mantovani, A.1    Bussolino, F.2    Dejana, E.3
  • 20
    • 0025213264 scopus 로고
    • Interferon-β augments suppressor cell function in multiple sclerosis
    • Noronha, A., Toscas, A. and Jensen, M.A. (1990) Interferon-β augments suppressor cell function in multiple sclerosis. Ann. Neurol. 27, 207-210.
    • (1990) Ann. Neurol. , vol.27 , pp. 207-210
    • Noronha, A.1    Toscas, A.2    Jensen, M.A.3
  • 21
    • 0041366377 scopus 로고
    • Interferon-β modulates immune function: Implications for multiple sclerosis
    • Noronha, A., Toscas, A. and Jensen, M.A. (1993) Interferon-β modulates immune function: implications for multiple sclerosis [abstract]. J. Immunol. 150, 148A.
    • (1993) J. Immunol. , vol.150
    • Noronha, A.1    Toscas, A.2    Jensen, M.A.3
  • 22
    • 0025817428 scopus 로고
    • MHC class-II molecules and autoimmunity
    • Neptom, G.T. and Erlich, H. (1991) MHC class-II molecules and autoimmunity. Annu. Rev. Immunol. 9, 493-520.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 493-520
    • Neptom, G.T.1    Erlich, H.2
  • 23
    • 0026756731 scopus 로고
    • Downregulation of interleukin-8 gene expression in human fibroblasts: Unique mechanism of transcriptional inhibition by interferon
    • Oliveira, I.C., Sciavolino, P.J., Lee, T.H. and Vilcek, J. (1992) Downregulation of interleukin-8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon. Proc. Natl. Acad. Sci, USA 89, 9049-9053.
    • (1992) Proc. Natl. Acad. Sci, USA , vol.89 , pp. 9049-9053
    • Oliveira, I.C.1    Sciavolino, P.J.2    Lee, T.H.3    Vilcek, J.4
  • 24
    • 0028175988 scopus 로고
    • GM-CSF, IL-1α, IL-1β, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated with LPS, IL-1 α and TNFα
    • Pang, G., Couch, L., Batey, R., Clancy, R. and Cripps, A. (1994) GM-CSF, IL-1α, IL-1β, IL-6, IL-8, IL-10, ICAM-1 and VCAM-1 gene expression and cytokine production in human duodenal fibroblasts stimulated with LPS, IL-1 α and TNFα. Clin. Exp. Immunol. 96, 437-443.
    • (1994) Clin. Exp. Immunol. , vol.96 , pp. 437-443
    • Pang, G.1    Couch, L.2    Batey, R.3    Clancy, R.4    Cripps, A.5
  • 25
    • 0039616728 scopus 로고
    • Recombinant interferon-β inhibits IFN-γ production in MS
    • Panitch, H.S., Folus, J.S. and Jonson, K.P. (1987a) Recombinant interferon-β inhibits IFN-γ production in MS [abstract]. Ann. Neurol. 22, 137.
    • (1987) Ann. Neurol. , vol.22 , pp. 137
    • Panitch, H.S.1    Folus, J.S.2    Jonson, K.P.3
  • 26
    • 0023221133 scopus 로고
    • Treatment of multiple sclerosis with gamma interferon: Exacerbations associated with activation of the immune system
    • Panitch, H.S., Hirsch, R.L., Schindler, J. and Jonson, K.P. (1987b) Treatment of multiple sclerosis with gamma interferon: exacerbations associated with activation of the immune system. Neurology 37, 1097-1102.
    • (1987) Neurology , vol.37 , pp. 1097-1102
    • Panitch, H.S.1    Hirsch, R.L.2    Schindler, J.3    Jonson, K.P.4
  • 27
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis of multicenter, randomized, double-blind, placebo-controlled trial
    • Paty, D.W., MS/MRI study group and The IFNβ Multiple Sclerosis Study Group (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis of multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43, 662-667.
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.W.1
  • 28
    • 0023141075 scopus 로고
    • Lymphokine regulation of HLA-DR gene expression in human thyroid cell monolayers
    • Piccini, L.A., Mackenzie, W.A., Platzer, M. and Davies, T.F. (1987) Lymphokine regulation of HLA-DR gene expression in human thyroid cell monolayers. J. Clin. Endocrin. Metab. 64, 543-548.
    • (1987) J. Clin. Endocrin. Metab. , vol.64 , pp. 543-548
    • Piccini, L.A.1    Mackenzie, W.A.2    Platzer, M.3    Davies, T.F.4
  • 29
    • 0025165359 scopus 로고
    • The role of endothelial cells in inflammation
    • Pober, J.S. and Cotran, R.S (1990a) The role of endothelial cells in inflammation. Transplantation 50, 537-544.
    • (1990) Transplantation , vol.50 , pp. 537-544
    • Pober, J.S.1    Cotran, R.S.2
  • 30
    • 0025304016 scopus 로고
    • Cytokines and endothelial cell biology
    • Pober, J.S. and Cotran, R.S. (1990b) Cytokines and endothelial cell biology. Physiol. Rev. 70, 427-451.
    • (1990) Physiol. Rev. , vol.70 , pp. 427-451
    • Pober, J.S.1    Cotran, R.S.2
  • 31
    • 0029420295 scopus 로고
    • Antagonism of interferon-beta on interferon gamma: Inhibition of signal transduction in vitro and reduction of serum levels in multiple sclerosis patients
    • Revel, M., Chebath, J., Mangelus, M., Harroch, S. and Moviglia, G.A. (1995) Antagonism of interferon-beta on interferon gamma: inhibition of signal transduction in vitro and reduction of serum levels in multiple sclerosis patients. Multiple Sclerosis 1, S5-S11.
    • (1995) Multiple Sclerosis , vol.1
    • Revel, M.1    Chebath, J.2    Mangelus, M.3    Harroch, S.4    Moviglia, G.A.5
  • 32
    • 0025000863 scopus 로고
    • An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental autoimmune encephalomyelitis
    • Ruddle, N.H., Bergman, C.M., McGrath, K., Lingenheld, E.G., Grunnet, M., Padula, S.J. and Clark, R.B. (1990) An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental autoimmune encephalomyelitis. J. Exp. Med. 172, 1193-1200.
    • (1990) J. Exp. Med. , vol.172 , pp. 1193-1200
    • Ruddle, N.H.1    Bergman, C.M.2    McGrath, K.3    Lingenheld, E.G.4    Grunnet, M.5    Padula, S.J.6    Clark, R.B.7
  • 33
    • 0027432017 scopus 로고
    • In vitro and in vivo inhibition of mitogen-driven T cell activation by recombinant interferon beta
    • Rudick, R.A., Carpenter, C.S., Cookfair, D.L., Tuohy, V.K. and Ransohoff, R.M. (1993) In vitro and in vivo inhibition of mitogen-driven T cell activation by recombinant interferon beta. Neurology 43, 2080-2087.
    • (1993) Neurology , vol.43 , pp. 2080-2087
    • Rudick, R.A.1    Carpenter, C.S.2    Cookfair, D.L.3    Tuohy, V.K.4    Ransohoff, R.M.5
  • 34
    • 0028817194 scopus 로고
    • Differential effects of beta and gamma interferons on expression of major histocompatibility complex antigens and intercellular adhesion molecule-1 in cultured fetal human astrocytes
    • Satoh, J., Paty, D.W. and Kim, S.U. (1995) Differential effects of beta and gamma interferons on expression of major histocompatibility complex antigens and intercellular adhesion molecule-1 in cultured fetal human astrocytes. Neurology 45, 367-373.
    • (1995) Neurology , vol.45 , pp. 367-373
    • Satoh, J.1    Paty, D.W.2    Kim, S.U.3
  • 36
    • 0025773147 scopus 로고
    • Association between tumor necrosis factor-α and disease progression in patients with multiple sclerosis
    • Sharief, M.K. and Hentges, R. (1991) Association between tumor necrosis factor-α and disease progression in patients with multiple sclerosis. N. Engl. J. Med. 325, 467-472.
    • (1991) N. Engl. J. Med. , vol.325 , pp. 467-472
    • Sharief, M.K.1    Hentges, R.2
  • 37
    • 0028926093 scopus 로고
    • Type I interferon inhibition of superantigen stimulation: Implication of treatment of superantigen-associated disease
    • Soos, J.M. and Johnson, H.M. (1995) Type I interferon inhibition of superantigen stimulation: implication of treatment of superantigen-associated disease. J. Interferon Cytokine Res. 15, 39-45.
    • (1995) J. Interferon Cytokine Res. , vol.15 , pp. 39-45
    • Soos, J.M.1    Johnson, H.M.2
  • 38
    • 0027982876 scopus 로고
    • Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
    • Springer, T.A. (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm. Cell 76, 301-314.
    • (1994) Cell , vol.76 , pp. 301-314
    • Springer, T.A.1
  • 39
    • 0027489765 scopus 로고
    • Binding of an SJL T cell clone specific for myelin basic protein to SJL brain microvessel endothelial cells is inhibited by anti-VLA-4 or its ligand VCAM-1 antibody
    • Tanaka, M., Sato, A., Makino, M. and Tabira, T. (1993) Binding of an SJL T cell clone specific for myelin basic protein to SJL brain microvessel endothelial cells is inhibited by anti-VLA-4 or its ligand VCAM-1 antibody. J. Neuroimmunol. 46, 253-257.
    • (1993) J. Neuroimmunol. , vol.46 , pp. 253-257
    • Tanaka, M.1    Sato, A.2    Makino, M.3    Tabira, T.4
  • 40
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. Clinical results of multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNβ Multiple Sclerosis Study Group (1993) Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. Clinical results of multicenter, randomized, double-blind, placebo-controlled trial. Neurology 43, 655-661.
    • (1993) Neurology , vol.43 , pp. 655-661
  • 41
    • 0025305624 scopus 로고
    • IL-4 increases human endothelial cell adhesiveness for T cells but not for neutrophils
    • Thotnhill, M.H., Kyan-Aung, U. and Hascard, D.O. (1990) IL-4 increases human endothelial cell adhesiveness for T cells but not for neutrophils J. Immunol. 144, 3060-3065.
    • (1990) J. Immunol. , vol.144 , pp. 3060-3065
    • Thotnhill, M.H.1    Kyan-Aung, U.2    Hascard, D.O.3
  • 42
    • 0026717674 scopus 로고
    • The pathophysiology of Tumor necrosis factors
    • Vassalli, P. (1992) The pathophysiology of Tumor necrosis factors. Annu. Rev. Immunol. 10, 411-452.
    • (1992) Annu. Rev. Immunol. , vol.10 , pp. 411-452
    • Vassalli, P.1
  • 43
    • 0039024452 scopus 로고
    • The potential role of cytokines in the treatment of viral infections
    • Warren, R.P. and Sidwell, R.W. (1994) The potential role of cytokines in the treatment of viral infections. Clin. Immunother. 1, 15-30.
    • (1994) Clin. Immunother. , vol.1 , pp. 15-30
    • Warren, R.P.1    Sidwell, R.W.2
  • 44
    • 0024502952 scopus 로고
    • Role of β2-microglobulin in the intracellular transport and surface expression of murine class-I histocompatibility molecules
    • Williams, D.B., Barber, B.H., Flavell, R.A. and Allen, H. (1989) Role of β2-microglobulin in the intracellular transport and surface expression of murine class-I histocompatibility molecules. J. Immunol. 142, 2796-2801.
    • (1989) J. Immunol. , vol.142 , pp. 2796-2801
    • Williams, D.B.1    Barber, B.H.2    Flavell, R.A.3    Allen, H.4
  • 45
    • 0026650384 scopus 로고
    • Upregulation of ICAM-1 expression in primary culture of human brain microvessel endothelial cells by cytokines and lipopolysaccharide
    • Wong, D. and Dorovini-Zis, K. (1992) Upregulation of ICAM-1 expression in primary culture of human brain microvessel endothelial cells by cytokines and lipopolysaccharide. J. Neuroimmunol. 39, 11-22.
    • (1992) J. Neuroimmunol. , vol.39 , pp. 11-22
    • Wong, D.1    Dorovini-Zis, K.2
  • 46
    • 0040802846 scopus 로고
    • Inflammation and ischemia: Implication for treatment
    • J, Krieglstein and H. Oberpichler-Schwenk (Eds.), Medpharm Scientific Publishers Stuttgart
    • Yasuma, Y., Tasaki, K., McCarron, R.M., Frerichs, K.U., Spatz, M. and Hallenbeck, J.M. (1994) Inflammation and ischemia: implication for treatment. In: J, Krieglstein and H. Oberpichler-Schwenk (Eds.), Pharmacology of Cerebral Ischemia. Medpharm Scientific Publishers Stuttgart, pp. 437-443.
    • (1994) Pharmacology of Cerebral Ischemia , pp. 437-443
    • Yasuma, Y.1    Tasaki, K.2    McCarron, R.M.3    Frerichs, K.U.4    Spatz, M.5    Hallenbeck, J.M.6
  • 47
    • 0028211553 scopus 로고
    • The signalling pathways of interleukin-6 and gamma-interferon converge by activation of different transcription factors which bind common responsive DNA elements
    • Yuan, J., Wgenka, U.M., Lutticken, C., Buschmann, J., Decker, T., Schindler, C., Heinrich, P. and Horn, F. (1994) The signalling pathways of interleukin-6 and gamma-interferon converge by activation of different transcription factors which bind common responsive DNA elements. Mol. Cell. Biol. 14, 1657-1668.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1657-1668
    • Yuan, J.1    Wgenka, U.M.2    Lutticken, C.3    Buschmann, J.4    Decker, T.5    Schindler, C.6    Heinrich, P.7    Horn, F.8


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