Cytoxicity of [(5,6-dichloro-9a-n-propyl-2,3,9,9a-tetrahydro-3-oxo-1H fluoren-7-yl)oxy]acetic acid, an agent known to reduce brain edema

Biomedicine and Pharmacotherapy

Volumn 50, Issue 1, 1996, Pages 19-23

  Hall, I H ^a   Wyrick, S D ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

Cytotoxic agents; Leukemia; Purine synthesis inhibitor

Indexed keywords

(5,6 DICHLORO 2,3,9,9A TETRAHYDRO 3 OXO 9A PROPYL 1H FLUOREN 7 YLOXY)ACETIC ACID; DIHYDROFOLATE REDUCTASE; ENZYME INHIBITOR;

ANIMAL CELL; ARTICLE; BRAIN EDEMA; CANCER CELL; CELL CULTURE; CELL METABOLISM; CYTOTOXICITY; DNA SYNTHESIS; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; RAT; RNA SYNTHESIS;

ACETIC ACIDS; ANIMALS; BRAIN EDEMA; CELL DIVISION; CYTOTOXICITY, IMMUNOLOGIC; HUMANS; LEUKEMIA L1210; MICE; PURINES; RATS; TUMOR CELLS, CULTURED;

EID: 0029669977     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/0753-3322(96)85093-1     Document Type: Article

References (33)

1. Wyrick SD, Smith FT, Kemp WE, Grippo AA. Effects of [(N-alkyl-1,3-dioxo-1H, 3H-isoindolin-5-y1)oxy]alkanoic acids, [(N-alkyl-1-oxo-1H, 3H-isoindolin-5-yl)]butanoic acids and related derivatives on chloride influx in primary asrtroglial cultures. J Med Chem 1987;30:1798
2. Waller CL, Wyrick SD, Park HM, Kemp WE, Smith FT. Effects of [N-alkyl-1,3-dihydro-1-oxoisoindolone-5-yl)alkanoic acids on chloride transport in primary astroglial cultures. J Pharm Sci 1994;83:571
3. Hall IH, Wong OT, Chi LK, Chen SY. The cytotoxicity of substituted indan-1.3-diones in murine and human tissue culture cells. Anticancer Drugs 1994;4:2053
4. Hall IH, Wong OT, Hall ES, Chen LK. The cytotoxicity of N-substituted indazolones in murine and human tumor cells. Anticancer Drugs 1993;4:389
5. Hall IH, Wong OT. The cytotoxicity of 3-imino-1-oxoisoindolines-in murine and human tissue culture cells. Anticancer Drugs 1994;5:207
6. Hall IH, Wyrick SD. The cytotoxicity of [(N-alkyl-1,3-dioxo-1H,3H-isoindolin-5-yl)oxylulkanoic acids in murine and human tissue cultured cell lines. Anticancer Res 1995;in press
7. Hall IH, Wyrick SD, Waller CL. The cytotoxicity of [(N-alkyl-1H, 3H-1-oxoisoindolin-5-yl)oxy]alkanoatcs and related benzamides in murine and human tissue cultures cell lines. Anticancer Res 1995;in press
8. Cragoe EJ, Jr, Woltersdorf OW, Jr. Gould NP et al. Agents for the treatment of brain edema. 2. [(2, 3, 9, 9a-tetrahydro-3-oxo-9a-substitutued -1H-fluoren-7-yl)oxylalkanoic acids and some of their analogs. J Med Chem 1986;29:825
9. Geran RJ, Greenburg NH, MacDonald MM, Schumacher AM, Abbott BJ. Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemo Rep 1972;3:9
10. Liao LL, Kupchan SM, Horwitz, SB. Mode of action of the antitumor compound bruceatin, an inhibitor of protein synthesis. Mol Pharmacol 1976;12:167
11. Cadman E, Heimer R, Benz C. The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells. J Biol Chem 1981;256:1695
12. Christopherson RI, Yu ML, Jones ME. An overall radioassay for the first three reactions of de novo pyrimidine synthesis. Anal Biochem 1981;11:240
13. Eichler DC, Fisher PA, Korn D. Effect of calcium on the recovery distribution of DNA polymerase from cultured human cells. J Biol Chem 1977;252:4011
14. Mamaril FP, Dobrjasky A, Green S. A rapid method for isolated of nuclei of Ehrlich ascites tumor cells. Cancer Res 1970;30:352
15. Sawada H, Tatsumi K, Sadada M, Shirakawa S, Nakamura T. Wakisaka G. Effects of neocarzinostatin on DNA synthesis in L1210 cells. Cancer Res 1974;34:3341
16. Anderson KM, Mendelson IS, Guzik G. Solubilized DNA-dependent nuclear RNA polymerases from the mammary g1 ands of late-pregnant rats. Biochem Biophys Acta 1975;383:56
17. Hall IH, Carlson GL, Abernathy GS, Piantadosi C. Cycloalkanones IV. Antifertility agents. J Med Chem 1974;17:1253
18. Moore EC, Hurlbert RB. Regulation of mammalian deoxyribonucletide biosynthesis by nucleotide or activators and inhibitors. J Biol Chem 1966;241:4802
19. Maley F, Ochoa S. Enzymatic phosphorylation of deoxycytidylic acid. J Biol Chem 1958;233:1538
20. Spassova MK, Russev GC, Goovinsky EV. Some pyrazoles as inhibitors of purine biosynthesis de novo. Biochem Pharmacol 1976;25:923
21. Becker JH, Lohr GW. Inosine-5′-phosphate dehydrogenase activity in normal and leukemic blood cells. Klin Wochenschr 1979;57:1109
22. Kalman SM, Duffield PH, Brzozwki TJ. Purification and properties of a bacterial carbamyl phosphate synthetase. J Biol Chem 1966;241:871
23. Archibald RM. Determination of citrulline and allontoin and demonstration of citrulline in blood plasma. J Biol Chem 1944;156:121
24. Koritz SB, Cohen PP. Colorimetic determination of carbamyl amino acid and related compounds. J Biol Chem 1954;209:145
25. Kampf A, Barfknecht RL, Schaffer PJ, Osaki S, Mertes MP. Synthetic inhibitors of Escherichia coli calf thymus and Ehrlich ascites tumor thymidylate synthetase. J Med Chem 1976;19:903
26. Ho YK, Hakala T, Zakrzewski SF. 5-(1-Adamatyl) pyrimidines as inhibitors of folate metabolism. Cancer Res 1971;32:1023
27. Lowry OH, Rosebrough J, Farr AL. Randall RJ. Protein measurement with folin phenol reagent. J Biol Chem 1951;193:265
28. Bagnara AS, Finch LR. Quantitative extraction and estimation of intracellular nucleostide-triphosphate in Escherichia coli. Anal Biochem 1971;45:24
29. Hunting D, Henderson JF. Determination of deoxyribonucleoside triphosphates using DNA polymerase: a critical evaluation. Can J Biochem 1982;59:723
30. Suzuki H, Nishimura T. Muto SK, Tanaka N. Mechanism of action of macromomycin: DNA strand scission, inhibition of DNA synthesis mitosis. J Antibacteriol 1978;32:875
31. Pera JF Sr, Rawlings CJ, Shackleton J, Roberts JJ. Quantitative aspects of the formation and loss of DNA. Biochem Biophy Acta 1981;655:152
32. Woynarowski JW, Beerman TA, Konopa J. Introduction of deoxyribonucleic acid damage in HeLa S3 cells by cytotoxic and antitumor sesquiterpine lactones. Biochem Pharmacol 1981;30:3005
33. Zhao Y, Hall IH, Oswald CB, Yokoi T, Lee KH. Anti-malarial agents III. Mechanism of action of artesunate against Plasmodium berghi infection. Chem Phar Bull 1987;35: 2052