Growth and a-amylase production by Aspergillus oryzae during continuous cultivations

Journal of Biotechnology

Volumn 45, Issue 1, 1996, Pages 81-93

  Carlsen, Morten ^a   Nielsen, Jens ^a   Villadsen, John ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Aspergillus oryzae; Continuous cultivation; Glucose metabolism; Protein production; Submerged growth

Indexed keywords

AMYLASE; GLUCOSE;

ARTICLE; ASPERGILLUS ORYZAE; CONTROLLED STUDY; ENZYME SYNTHESIS; FUNGUS GROWTH; GLUCOSE METABOLISM; NONHUMAN; PRIORITY JOURNAL;

BIOMASS; CARBON; ENZYMES; GLUCOSE; GROWTH KINETICS; PLANT CELL CULTURE; PROTEINS; RECOVERY; SATURATION (MATERIALS COMPOSITION); SYNTHESIS (CHEMICAL);

AMYLASE; ASPUGILLUS ORYZAE; GLUCOSE UPTAKE; MYCELLIUM; PROTEIN SYNTHESIS SYSTEM;

FUNGI;

EID: 0029669439     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/0168-1656(95)00147-6     Document Type: Article

References (30)

1. Barbesgaard, P., Heldt-Hansen H.P. and Diderichsen B. (1992) Mini-review - On the safety of Aspergillus oryzae. Appl. Microbiol. Biotechnol. 36, 569-572.
2. Benthin, S., Nielsen, J. and Villadsen, J. (1991) A simple and reliable method for the determination of cellular RNA content. Biotech. Tech. 5, 39-42.
3. Benthin, S., Nielsen, J. and Villadsen, J. (1992) Flow injection analysis of micromolar concentration of glucose and lactate in fermentation media. Anal. Chim. Acta 261, 145-153.
4. Bhella, R.S. and Altosaar, I. (1987) Translational control of α-amylase gene expression in Aspergillus awamori. Biotechnol. Appl. Biochem. 9, 287-293.
5. Brown, C.E. and Romano, A.H. (1969) Evidence against necessary phosphorylation during hexose transport in Aspergillus nidulans. J. Bacteriol. 100, 1198-1203.
6. Carlsen, M. (1994) α-Amylase production by Aspergillus oryzae. Ph.D. thesis. Department of Biotechnology. Technical University of Denmark, Lyngby, Denmark.
7. Carlsen, M., Marcher, J. and Nielsen, J. (1994) An improved FIA-method for measuring α-amylase in cultivation media. Biotech. Tech. 8, 479-482.
8. Carlsen, M., Nielsen, J. and Villadsen, J. (1995a) Investigation of pH-stability of α-amylase from Aspergillus oryzae. Chem. Sci. Eng., in press.
9. Carlsen, M., Spohr, A.B., Nielsen, J. and Villadsen, J. (1995b) Morphology and physiology of an α-amylase producing strain of Aspergillus oryzae during batch cultivations. Biotech. Bioeng., in press.
10. Chang, P.L.Y. and Trevithick, J.R. (1974) How important is secretion of exoenzymes through apical cell walls of fungi? Arch. Microbiol. 101, 281-293.
11. Christensen, T., Woeldike, H., Boel, E., Mortensen, S.B., Hjortshoej, K., Thim, L. and Hansen, M.T. (1988) High level expression of recombinant genes in Aspergillus oryzae. Bio/Technology 6, 1419-1422.
12. Erratt, J.A., Douglas, P.E., Moranelli, F. and Seligy, V.L. (1984) The induction of α-amylase by starch in Aspergillus oryzae: evidence for controlled mRNA expression. Can. J. Biochem. Cell Biol. 62, 678-690.
13. Garraway, M.O. and Evans, R.C. (1984) Fungal Nutrition and Physiology. John Wiley & Sons, New York.
14. Hansen, P.W. (1984) Determination of fungal α-amylase by flow injection analysis. Anal. Chim. Acta 158, 375-377.
15. Huge-Jensen, B. Andreasen, F., Christensen, T., Christensen, M., Thim, L. and Boel, E. (1989) Rhizomucor miehei triglyceride lipase is processed and secreted from transformed Aspergillus oryzae. Lipids 24, 781-785.
16. Lachmund, A., Urmann, U., Minol, K., Wirsel, S. and Ruttkowski, E. (1993) Regulation of α-amylase formation in Aspergillus oryzae and Aspergillus nidulans transformants. Curr. Microbiol. 26, 47-51.
17. Laemmli, U.K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.) 227, 680-685.
18. Mark, C.G. and Romano, A.M. (1971) Properties of the hexose transport systems of Aspergillus nidulans. Biochim. Biophys. Acta 249, 216-226.
19. Mason, H.R.S. and Righelato, R.C. (1976) Energetics of fungal growth: the effect of growth-limiting substrates on respiration of Penicillium chrysogenum. J. Appl. Chem. Biotechnol. 26, 145-152.
20. Mørkeberg, R., Carlsen, M. and Nielsen, J. (1995) Induction and repression of α-amylase production in batch and continuous cultures of Aspergillus oryzae. Microbiology 141, 2449-2454.
21. Nielsen, J. and Villadsen, J. (1994) Bioreaction Engineering Principles. Plenum Press, New York.
22. Nielsen, J., Johansen, C.L., Jacobsen, M., Krabben, P. and Villadsen, J. (1995) Pellet formation and fragmentation in submerged cultures of Penicillium chrysogenum and its relation to penicillin production. Biotechnol. Prog. 11, 93-98.
23. Peberdy, J.F. (1994) Protein secretion in filamentous fungi-trying to understand a highly productive black box. Trends in Biotechnology 12, 50-57.
24. Piper, P.W., Curran, B., Davies, M.W., Hirst, K., Lockheart, A. and Seward, K. (1988) Catabolite control of the elevation of PGK mRNA levels by heat shock in Saccharomyces cerevisiae. Mol. Microbiol. 2, 353-361.
25. Schneider, R.P. and Wiley, W.R. (1971) Kinetic characteristics of the two glucose transport systems in Neurospora crassa. J. Bacteriol. 106, 479-486.
26. Schrickx, J.M., Krave, A.S., Verdoes, J.C., Van den Hondel, C.A.M.J.J., Stouthamer, A.M. and van Verseveld, H.W. (1993) Growth and product formation in chemostat and recycling cultures by Aspergillus niger N402 and a glucoamylase over-production transformant, provided with multiple copies of the glaA gene. J. Gen. Microbiol. 139, 2801-2810.
27. Tada, S., Iimura, Y., Gomi, K., Takahashi, K., Hara, S. and Yoshizawa, K. (1989) Cloning and nucleotide sequence of the genomic Taka-amylase A gene of Aspergillus oryzae. Agric. Biol. Chem. 53, 593-599.
28. Tada, S., Gomi, K., Kitamoto, K., Takahashi, K., Tamura, G. and Hara, S. (1991) Construction of a fusion gene comprising the Taka-amylase A promoter and the Escherichia coli β-glucuronidase gene and analysis of its expression in Aspergillus oryzae. Mol. Gen. Genet. 229, 301-306.
29. Yabuki, M., Ono, N., Hoshino, K. and Fukui, S. (1977) Rapid induction of α-amylase by nongrowing mycelia of Aspergillus oryzae. Appl. Environ. Microbiol. 34, 1-6.
30. Wösten, H.A.B., Moukha, S.M., Sietsma, J.H. and Wessels, J.G.H. (1991) Localization of growth and secretion of proteins in Aspergillus niger. J. Gen. Microbiol. 137, 2017-2023.