Propanolol suppression of ocular HSV-1 recurrence and associated corneal lesions following spontaneous reactivation in the rabbit

Current Eye Research

Volumn 15, Issue 6, 1996, Pages 680-684

  Kaufman, Herbert E ^a,b   Varnell, Emily D ^a   Gebhardt, Bryan M ^a   Thompson, Hilary W ^a   Hill, James M ^a  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b LSU EYE CENTER   (United States)

Author keywords

Cornea; Herpes virus latency; Propranolol; Rabbit; Reactivation

Indexed keywords

PROPRANOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA INJURY; DRUG EFFICACY; FEMALE; HERPES; HERPES SIMPLEX VIRUS 1; INTRAMUSCULAR DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; RABBIT; VIRUS LATENCY; ANIMAL; CORNEA; DRUG EFFECT; EPITHELIUM; HERPES SIMPLEX KERATITIS; MOUSE; PATHOLOGY; RECURRENT DISEASE;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CORNEA; EPITHELIUM; FEMALE; KERATITIS, HERPETIC; MALE; MICE; PROPRANOLOL; RABBITS; RECURRENCE;

EID: 0029666465     PISSN: 02713683     EISSN: None     Source Type: Journal    
DOI: 10.3109/02713689609008909     Document Type: Article

References (28)

1. Straus, S. E., Moderator, Rooney, J. F., Sever, J. L., Seidlin, M., Nusinoff-Lehrman, S. and Cremer, K. (1985) Discussants NIH Conference. Herpes simplex virus infection: Biology, treatment, and prevention. Ann. Int. Med. 103, 404-419.
2. Cook, S. D. (1992) Herpes simplex virus in the eye. Br. J. Ophthalmol. 76, 365-366.
3. Harding, S. P. (1993) Viral infections of the eye. Reviews in Medical Virology, 3, 161-171.
4. Varnell, E. D., Kaufman, H. E., Hill, J. M. and Thompson, H. W. (1995) Cold stress-induced recurrences of herpetic keratitis in the squirrel monkey. Invest. Ophthalmol. Vis. Sci. 36, 1181-1183.
5. Laibson, P. R. and Kibrick, S. (1966) Reactivation of herpetic keratitis by epinephrine in rabbit. Arch. Ophthalmol. 75, 254-260.
6. Kwon, B. S. Ocular herpes simplex virus shedding by iontophoresis or epinephrine into rabbit cornea. Invest. Ophthalmol. Vis. Sci. 21, 442-449.
7. Kwon, B. S., Gangarosa, L. P., Green, K. and Hill, J. M. (1982) Kinetics of ocular herpes simplex virus shedding induced by epinephrine iontophoresis. Invest. Ophthalmol. Vis. Sci. 22, 818-821.
8. Hill, J. M., Shimomura, Y., Kwon, B. S. and Gangarosa, L. P. (1985) Iontophoresis of epinephrine isomers to rabbit eyes. Induced HSV-1 ocular shedding. Invest. Ophthalmol. Vis. Sci. 26, 1299-1303.
9. Hill, J. M., Dudley, J. B., Shimomura, Y. and Kaufman, H. E. (1986) Quantitation and kinetics of induced HSV-1 ocular shedding. Curr. Eye Res. 5, 241-246.
10. Shimomura, Y., Gangarosa, L. P., Sr., Kataoka, M. and Hill, J. M. (1983) HSV-1 shedding by iontophoresis of 6-hydroxydopamine followed by topical epinephrine. Invest. Ophthalmol. Vis. Sci. 24, 1588-1594.
11. Hill, J. M., Haruta, Y. and Rootman, D. S. (1987) Adrener-gically induced recurrent HSV-1 corneal epithelial lesions. Curr. Eye Res. 6, 1065-1071.
12. Hill, J. M., Shimomura, Y., Dudley, J. B., Berman, E., Haruta, Y., Kwon, B. S. and Maguire, L. J. (1987) Timolol induces HSV-1 ocular shedding in the latently infected rabbit. Invest. Ophthalmol. Vis. Sci. 28, 585-590.
13. Haruta, Y., Rootman, D. S. and Hill, J. M. (1988) Recurrent HSV-1 corneal epithelial lesions induced by timolol iontophoresis in latently infected rabbits. Invest. Ophthalmol. Vis. Sci. 29, 387-392.
14. Gordon, Y. I., Romanowski, E., Berman, J., Vikoren, P., Lin, L. S., Schlessinger, D. and Araullo-Cruz, T. (1990) Vanadate promotes reactivation and iontophoresis-induced ocular shedding of latent HSV-1 W in different host animals. Curr. Eye Res. 9, 1015-1021.
15. Gordon, Y. I., Romanowski, E., Harwick, J., Berman, J., Olsakovsky, L. and Araullo-Cruz, T. (1990) The effect of alpha blockade on iontophoresis-induced ocular shedding of latent HSV-1 W in different host animals. Curr. Eye Res. 9, 1007-1014.
16. Hill, J. M., Rayfield, M. A. and Haruta, Y. (1987) Strain specificity of spontaneous and adrenergically induced HSV-1 ocular reactivation in latently infected rabbits. Curr. Eye Res. 6, 91-97.
17. Gebhardt, B. M. and Kaufman, H. E. (1995) Propranolol suppresses reactivation of herpesvirus. Antiviral Res. 27, 255-261.
18. Milliken, G. A. and Johnson, D. E. (1984) Analysis of Messy Data, Volume I: Designed Experiments. Pp. 413-423. Van Nostrand Reinhold, New York, NY.
19. Siegel, S. (1956) Nonparametric Statistics for the Behavioral Sciences. Pp. 35-60. McGraw-Hill Book Co., New York, NY.
20. Beyer, C. F., Hill, J. M., Reidy, J. J. and Beuerman, R. W. (1990) Corneal nerve disruption reactivates virus in rabbits latently infected with HSV-1. Invest. Ophthalmol. Vis. Sci. 31, 925-932.
21. Haruta, Y., Maguire, L. J., Rootman, D. S. and Hill, J. M. (1987) Recurrent herpes simplex virus type 1 corneal epithelial lesions after radial keratotomy in the rabbit. Arch. Ophthalmol. 105, 692-694.
22. Portnoy, S. L., Beyer, C. F., Hill, J. M. and Kaufman, H. E. (1991) The coincidence of HSV-1 ocular cultures with HSV-1 corneal epithelial defects in rabbits after experimental penetrating keratoplasty. Cornea, 10, 17-20.
23. Spruance, S. L., Freeman, D. J., Stewart, J. C. B., McKeough, M. B., Wenerstrom, L. G., Krueger, G. G., Piepkorn, M. W., Stroop, W. G. and Rowe, N. H. (1991) The natural history of ultraviolet radiation-induced herpes simplex labialis and response to therapy with peroral and topical formulations of acyclovir. J. Infect. Dis. 163, 728-734.
24. Gebhardt, B. M. and Hill, J. M. (1988) T lymphocytes in the trigeminal ganglia of rabbits during corneal HSV infection. Invest. Ophthalmol. Vis. Sci. 29, 1683-1691.
25. Catnin, E. M., Hinton, D. R., Chen, J. and Openshaw, H. (1995) Gamma interferon expression during acute and latent nervous system infection by herpes simplex virus type 1. J. Virol. 69, 4898-4905.
26. Liu, T., Tang, Q. and Hendricks, R. L. (1996) Inflammatory infiltration of the trigeminal ganglion after herpes simplex virus type 1 corneal infection. J. Virol. 70, 264-271.
27. Olin, B. R., Ed. (1993) Drug Facts and Comparisons.® Pp. 750-771. Facts and Comparisons, St. Louis, MO.
28. Bennett, D. R., Ed. (1994) Drug Evaluations Annual 1994. Pp. 539-549. American Medical Association, Chicago, IL.