Expression of the human α2 integrin subunit in mouse melanoma cells confers the ability to undergo collagen-directed adhesion, migration, and matrix reorganization

Journal of Investigative Dermatology

Volumn 106, Issue 6, 1996, Pages 1175-1181

  Schön, Margarete ^a,d   Schön, Michael P ^a   Kuhröber, Andreas ^b   Schirmbeck, Reinhold ^b   Kaufmann, Roland ^c   Klein, C Eberhard ^d  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF ULM   (Germany)

^c GOETHE UNIVERSITY   (Germany)

^d UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

collagen receptor; integrins; VLA 2

Indexed keywords

COLLAGEN RECEPTOR; COLLAGEN TYPE 1; INTEGRIN; UNCLASSIFIED DRUG; ALPHA2 INTEGRIN; BETA1 INTEGRIN; COLLAGEN; LEUKOCYTE ANTIGEN;

ANIMAL CELL; ARTICLE; CELL ADHESION; CONTROLLED STUDY; MELANOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR GROWTH; ANIMAL; CELL CULTURE; CELL MOTION; EXTRACELLULAR MATRIX; GENETIC TRANSFECTION; HUMAN; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ANIMALS; ANTIGENS, CD; ANTIGENS, CD29; CELL ADHESION; CELL MOVEMENT; COLLAGEN; EXTRACELLULAR MATRIX; HUMANS; INTEGRIN ALPHA2; MELANOMA; MICE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0029666229     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/1523-1747.ep12347929     Document Type: Article

References (29)

1. 3 subunit with tumor progression. Cancer Res 50:6757-6764, 1990
2. Argraves WS, Suzuki S, Avai H, Thompson K, Pierschbacher MD, Ruoslathi E: Amino acid sequence of the human fibronectin receptor. J Cell Biol 105:1183-1190, 1987
3. 1 subunit. J Cell Biol 117:659-670, 1992
4. Artelt P, Morelle C, Ausmeier M, Fitzek M, Hauser HJ: Vectors for efficient expression in mammalian fibroblastoid, myeloid and lymphoid cells via transfection or infection. Gen 68:213-219, 1988
5. Chan BMC, Matsuura N, Takada Y, Zetter BR, Hemler ME: In vitro and in invo consequences of VLA-2 expression in rhabdomyosarcoma cells. Science 251: 1600-1602, 1990
6. Chen FA, Repasky EA, Bankert RB: Human lung tumor-associated antigen identified as an extracellular matrix adhesion molecule. J Exp Med 173:1111-1119, 1991
7. v gene expression in human melanoma tumorigenicity. J Clin Invest 89:2018-2022, 1992
8. Felgner PL, Gadek TR, Hohn M, Roman R, Chan HW, Wenz M, Northrop JP, Ringold GM, Danielsen M: Lipofectin: a highly efficient, lipid-mediated DNA-transfection procedure. Proc Natl Acad Sci USA 84:7413-7417, 1987
9. 1 fibronectin receptor suppress the transformed phenotype of Chinese hamster ovary cells. Cell 60:849-859, 1990
10. Humphries MJ, Mould AP, Yamada KM: Matrix receptors in cell migration. In: McDonald JA, Mecham RP (eds.). Receptors for Extracellular Matrix. Academic Press, San Diego, 1991
11. Hynes RO: Integrins: versatility, modulation and signaling in cell adhesion. Cell 69:11-25, 1992
12. 1 is upregulated in fibroblasts and highly aggressive melanoma cells in 3-dimensional collagen lattices and mediates the reorganization of collagen I fibrils. J Cell Biol 115:1427-1436, 1991
13. Kramer RH, Marks N: Identification of integrin collagen receptors on human melanoma cells. J Biol Chem 264:15642-15649, 1989
14. Mauch CA, Hatamochi A, Scharfetter K, Krieg T: Regulation of collagen synthesis in fibroblasts within a 3-dimensional collagen gel. Exp Cell Res 178:493-503, 1988
15. 3 to adhere to lymph node vitronectin. J Clin Invest 90:1406-1413, 1992
16. Plantefaber LC, Hynes RO: Changes in integrin receptors on oncogenically transformed cells. Cell 56:281-290, 1989
17. 1 on melanoma cells can inhibit the invasive stage of metastasis formation. Cell 77:335-347, 1994
18. Quevedo WC, Dyckman J, Halaban R, Moellmann GE, Cowan JM, Holstein TJ: The BULT melanoma: a spontaneous transplantable tumor in mice. Pigment Cell Res 1 (suppl):124-131, 1988
19. Rünger TM, Klein CE, Becker JC, Bröcker EB: The role of genetic instability, adhesion, cell motility and immune escape mechanisms in melanoma progression. Curr Opin Oncol 6:188-196, 1994
20. 1 (VLA-2) mediates reorganization and contraction of collagen matrices by human cells. Cell 67:403-410, 1991
21. Schwartz MA: Signaling by integrins: implications for tumorigenesis. Cancer Res 53:1503-1506, 1993
22. Solowska J, Guan J-L, Marcantonio EE, Trevithick JE, Buck CA, Hynes RO: Expression of normal and mutant avian integrin subunits in rodent cells. J Cell Biol 109:853-861, 1989
23. 2-subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain. J Cell Biol 109:397-407, 1989
24. van Muijen GNP, Cornelissen IMHA, Jansen CFJ, Ruiter DJ: Progression markers in metastasizing human melanoma cells xenografted to nude mice. Anticancer Res 9:879-884, 1989
25. Virtanen I, Korhonen M, Kariniemi AL, Gould VE, Laitinen L, Ylänne J: Integrins in human cells and tumors. Cell Different Dev 32:215-228, 1990
26. 6 integrin receptors in pancreatic carcinoma. Int J Cancer 52:827-833, 1992
27. 1 integrin in cell motility and fibronectin matrix assembly. J Cell Sci 108:821-829, 1995
28. Zetter BR: Adhesion molecules in tumor metastasis. Semin Cancer Biol 4:219-229, 1993
29. Zylstra S, Chen FA, Ghosh SK, Repasky EA, Rao U, Takita H, Bankert RB: Membrane-associated glycoprotein (gp 160) identified on human lung tumors by a monoclonal antibody. Cancer Res 46:6446-6451, 1986