The effects of the phospholipase A2 inhibitor, manoalide, on cartilage degradation, stromelysin expression, and synovial fluid cell count induced by intraarticular injection of human recombinant interleukin-1α in the rabbit

Arthritis and Rheumatism

Volumn 39, Issue 8, 1996, Pages 1292-1299

  Schrier, Denis J ^a   Flory, Craig M ^a   Finkel, Martin ^a   Kuchera, Susan L ^a   Lesch, Mark E ^a   Jacobson, Peer B ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MANOALIDE; PHOSPHOLIPASE A2; PROTEOGLYCAN; RECOMBINANT INTERLEUKIN 1ALPHA; STROMELYSIN; INTERLEUKIN 1; MESSENGER RNA; METALLOPROTEINASE; NONSTEROID ANTIINFLAMMATORY AGENT; PHOSPHODIESTERASE INHIBITOR; PHOSPHOLIPASE A; RECOMBINANT PROTEIN; TERPENE; TUMOR PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CARTILAGE DEGENERATION; CELL COUNT; CONTROLLED STUDY; ENZYME INHIBITION; INFLAMMATION; INFLAMMATORY CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RABBIT; SYNOVIAL FLUID; SYNOVIUM; ANIMAL; CARTILAGE; CHEMICALLY INDUCED DISORDER; CYTOLOGY; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; GENE EXPRESSION; GENETICS; HUMAN; INTRAARTICULAR DRUG ADMINISTRATION; METABOLISM;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS; CARTILAGE; CELL COUNT; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; INJECTIONS, INTRA-ARTICULAR; INTERLEUKIN-1; MALE; MATRIX METALLOPROTEINASE 3; METALLOENDOPEPTIDASES; NEOPLASM PROTEINS; PHOSPHODIESTERASE INHIBITORS; PHOSPHOLIPASES A; RABBITS; RECOMBINANT PROTEINS; RNA, MESSENGER; SYNOVIAL FLUID; TERPENES;

EID: 0029666138     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.1780390805     Document Type: Article

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