Cerebrovascular responsiveness to NG-nitro-L-arginine methyl ester in spontaneously diabetic rats

British Journal of Pharmacology

Volumn 118, Issue 2, 1996, Pages 243-248

  Fouyas, Ioannis P ^a   Kelly, Paul A T ^a   Ritchie, Isobel M ^a   Whittle, Ian R ^a  

^a UNIVERSITY OF EDINBURGH   (United Kingdom)

Author keywords

Cerebral blood flow; Diabetes mellitus; L NAME; Nitric oxide; Nitric oxide synthase inhibition; Quantitative autoradiography

Indexed keywords

IODOPHENAZONE C 14; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE INHIBITOR; ARGININE; DRUG DERIVATIVE; ENZYME INHIBITOR; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; HYPOTHALAMUS; INSULIN DEPENDENT DIABETES MELLITUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BIOBREEDING RAT; BRAIN CIRCULATION; DRUG ANTAGONISM; DRUG EFFECT; PATHOPHYSIOLOGY;

ANIMALS; ARGININE; CEREBROVASCULAR CIRCULATION; DIABETES MELLITUS, TYPE 1; ENZYME INHIBITORS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; RATS; RATS, INBRED BB;

EID: 0029665949     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15394.x     Document Type: Article

References (54)

1. ARONSON, S.M. (1973). Intracranial vascular lesions in patients with diabetes mellitus. J. Neuropathol. Exp. Neurol., 32, 183-196.
2. BAIRD, J.D. (1989). Relevance of the BB rat as a model for human insulin-dependent (Type I) diabetes mellitus. In Recent Advances in Endocrinology and Metabolism. ed. Edwards, C.R.W. & Lincoln, D.W. pp. 253-280. Edinburgh: Churchill Livingstone.
3. BARNES, A.J., LOCKE, P., SCUDDER, P.R., DORMANDY, T.L., DORMANDY, J.A. & SLACK, J. (1977). Is hyperviscosity a treatable component of diabetic microcirculatory disease? Lancet, ii, 789-791.
4. BROWN, M.M. & MARSHALL, J. (1985). Regulation of cerebral blood flow in response to changes in blood viscosity. The Lancet, i, 604-609.
5. BUCALA, R. & CERAMI, A. (1992). Advanced glycosylation: chemistry, biology, and implications for diabetes and aging. Ad. Pharmacol., 23, 1-34.
6. BUCALA, R., TRACEY, K. & CERAMI, A. (1991). Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J. Clin. Invest., 87, 432-438.
7. CAMERON, N.E. & COTTER, M.A. (1995). Neurovascular dysfunction in diabetic rats. Potential contribution of autoxidation and free radicals examined using transition metal chelating agents. J. Clin. Invest., 96, 1159-1163.
8. COHEN, R.A. (1993). Dysfunction of vascular endothelium in diabetes mellitus. Circulation, 87, [suppl V], V67-V76.
9. COLWELL, J.A. (1991). Pathophysiology of vascular disease in diabetes: Effects of Gliclazide. Am. J. Med., 90, [suppl 6A], 50S-54S.
10. CORBETT, J.A., TILTON, R.G., CHANG, K., HASAN, K.S., IDO, Y., WANG, J.I., SWEETLAND, M.A., LANCASTER, J.R., WILLIAMSON, J.R. & MCDANIEL, M.I. (1992). Aminoguanidine, a novel inhibitor of NO formation, prevents diabetic vascular dysfunction. Diabetes, 41, 552-556.
11. DUCKROW, R.B., BEARD, D.C. & BRENNAN, R.W. (1987). Regional CBF decreases during chronic and acute hyperglycemia. Stroke, 18, 52-58.
12. EIZIRIK, D.L., PIPELEERS, D.G., LING, Z., WELSH, N., HELLERSTRÖM, C. & ANDERSSON, A. (1994). Major species differences between humans and rodents in the susceptibility to pancreatic β-cell injury. Proc. Natl. Acad. Sci. U.S.A., 91, 9253-9256.
13. FARACI, F.M. & BRIAN, J.E. JR. (1994). Nitric oxide and the cerebral circulation. Stroke, 25, 692-703.
14. G-monomethyl-L-arginine (L-NMMA) in conscious rats. Br. J. Pharmacol., 114, 74P.
15. 2 reactivity in people with diabetes. Diabet. Med., 4, 217-220.
16. GRILL, V., GUTNIAK, M., BJÖRKMAN, O., LINDQVIST, M., STONE-ELANDER, S., SEITZ, R.J., BLOMQVIST, G., REICHARD, P. & WIDÉN, L. (1990). Cerebral blood flow and substrate utilization in insulin-treated subjects. Am. J. Physiol., 258, E813-E820.
17. GRUNNET, M.L. (1963). Cerebrovascular disease; diabetes and cerebral atherosclerosis. Neurology, 13, 486-491.
18. HARIK, S.I. & LAMANNA, J.C. (1988). Vascular perfusion and blood-brain glucose transport in acute and chronic hyperglycemia. J. Neurochem., 51, 1924-1929.
19. JAKOBSEN, J., NEDERGAARD, M., AARSLEW-JENSEN, M. & DIEMER, N.H. (1990). Regional brain glucose metabolism and blood flow in streptozocin-induced diabetic rats. Diabetes, 39, 437-440.
20. JØRGENSEN, H.S., NAKAYAMA, H., RAASCHOU, H.O. & OLSEN, T.S. (1994). Stroke in patients with diabetes. The Copenhagen Stroke Study. Stroke, 25, 1977-1984.
21. KANNEL, W.B. & MCGEE, D.L. (1979). Diabetes and cardiovascular risk factors: the Framingham study. Circulation, 59, 8-13.
22. KASTRUP, J., RØRSGAARD, S., PARVING, H.-H. & LASSEN, N.A. (1986). Impaired autoregulation of cerebral blood flow in long-term Type I diabetic patients with nephropathy and retinopathy. Clin. Physiol., 6, 549-559.
23. G-nitro-L-arginine methyl ester in vivo. Br. J. Pharmacol., 115, 63P.
24. G-nitro-L-arginine methyl ester. Neuroscience, 59, 13-20.
25. KETY, S.S., POLIS, B.D., NADLER, C.S. & SCHMIDT, C.F. (1948). Blood flow and oxygen consumption of human brain in diabetic acidosis and coma. J. Clin. Invest., 27, 500-510.
26. G-nitro-L-arginine methyl ester on regional haemodynamics in conscious rats with streptozotocin-induced diabetes mellitus. Br. J. Pharmacol., 103, 1321-1326.
27. KIFF, R.J., GARDINER, S.M., COMPTON, A.M. & BENNETT, T. (1991b). Selective impairment of hindquarters vasodilator responses to bradykinin in conscious Wistar rats with streptozotocin-induced diabetes mellitus. Br. J. Pharmacol., 103, 1357-1362.
28. KIHARA, M. & LOW, P.A. (1995). Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy. Exp. Neurol., 132, 180-185.
29. KIMURA, M., DIETRICH, H.H. & DACEY, R.G. JR. (1994). NO regulates cerebral arteriolar tone in rats. Stroke, 25, 2227-2234.
30. ω-Nitro-L-arginine methyl ester reduces the incidence of IDDM in BB/E rats. Diabetes, 44, 365-368.
31. MACLEOD, K.M., HEPBURN, D.A., DEARY, I.J., GOODWIN, G.M., DOUGALL, N., EBMEIER, K.P. & FRIER, B.M. (1994). Regional cerebral blood flow in IDDM patients: effects of diabetes and of recurrent severe hypoglycaemia. Diabetologia, 37, 257-263.
32. MACMILLAN, D.E., UTTERBACK, N.G. & LAPUMA, J. (1978). Reduced erythrocyte deformity in diabetes. Diabetes, 27, 895-901.
33. MACRAE, I.M., DAWSON, D.A., NORRIE, J.D. & MCCULLOCH, J. (1993). Inhibition of nitric oxide synthesis: Effects on cerebral blood flow and glucose utilisation in the rat. J. Cereb. Blood Flow Metab., 13, 985-992.
34. MANS, A.M., DEJOSEPH, R., DAVIS, D.W. & HAWKINS, R.A. (1987). Regional amino acid transport into brain during diabetes: effect of plasma amino acids. Am. J. Physiol., 253, E575-E583.
35. MARLISS, E.B., NAKHOODA, A.F., POUSSIER, P. & SIMA, A.A.F. (1982). The diabetic syndrome of the 'BB' Wistar rat: Possible relevance to Type 1 (Insulin-dependent) diabetes in man. Diabetologia, 22, 225-232.
36. MAYHAN, W.G. (1989). Impairment of endothelium-dependent dilatation of cerebral arterioles during diabetes mellitus. Am. J. Physiol., 256, H621-H625.
37. MAYHAN, W.G. (1994). Effects of diabetes mellitus on responses of the rat basilar artery to activation of beta-adrenergic receptors. Brain Res., 659, 208-212.
38. MAYHAN, W.G., SIMMONS, L.K. & SHARPE, G.M. (1991). Mechanism of impaired responses of cerebral arterioles during diabetes mellitus. Am. J. Physiol., 260, H319-H326.
39. MCCALL, A.L. (1992). The impact of diabetes on the CNS. Diabetes, 41, 557-570.
40. MERAJI, S., JAYAKODY, L., SENARATNE, M.P.J., THOMPSON, A.B.R. & KAPPAGODA, T. (1987). Endothelium-dependent relaxation in aorta of BB rat. Diabetes, 36, 978-981.
41. MOORADIAN, A.D. (1988). Diabetes and the central nervous system. Endocr. Rev., 9, 346-356.
42. NEDERGAARD, M. & DIEMER, N.H. (1987). Focal ischemia of the rat brain, with special reference to the influence of plasma glucose concentration. Acta Neuropathol, 73, 131-137.
43. PELLIGRINO, D.A. & ALBRECHT, R.F. (1991). Chronic hyperglycemic diabetes in the rat is associated with a selective impairment of cerebral vasodilatory responses. J. Cereb. Blood Flow Metab., 11, 667-677.
44. PELLIGRINO, D.A., MILETICH, D.J. & ALBRECHT, R.F. (1992). Diminished muscarinic receptor-mediated cerebral blood flow response in STZ-treated rats. Am. J. Physiol., 262, E447-E454.
45. POSTON, L. & TAYLOR, P.D. (1995). Endothelium-mediated vascular function in insulin-dependent diabetes mellitus (editorial review). Clin. Sci., 88, 245-255.
46. REICHARD, P., NILSSON, B.-Y. & ROSENQVIST, U. (1993). The effect of long-term intensified insulin treatment on the development of microvascular complications of diabetes mellitus. New Engl. J. Med., 329, 304-309.
47. RICHARD, V., HOGIE, M., CLOZEL, M., LÖFFLER, B.-M. & THUILLEZ, C. (1995). In vivo evidence of an endothelin-induced vasopressor tone after inhibition of nitric oxide synthesis in rats. Circulation, 91, 771-775.
48. ROSENBLUM, W.I. & LEVASSEUR, J.E. (1984). Microvascular responses of intermediate-size arterioles on the cerebral surface of diabetic mice. Microvasc. Res., 28, 368-372.
49. 14C]-antipyrine. Am. J. Physiol., 234, H59-H66.
50. SMITH, M.-L., VON HANWEHR, R. & SIESJÖ, B.K. (1986). Changes in extra- and intracellular pH in the brain during and following ischemia in hyperglycemic and in moderately hypoglycemic rats. J. Cereb. Blood Flow Metab., 6, 574-583.
51. 31P magnetic resonance spectroscopy. Diabetes, 41, 1328-1334.
52. 2+ response and EDRF formation in vascular endothelial cells. Diabetes, 43, 984-991.
53. 2 carrier. J. Cereb. Blood Flow Metab., 14, 871-876.
54. WAUTIER, J.-L., PATON, R.C., WAUTIER, M.P., PINTIGNY, D., ABADIE, E., PASSA, P. & CAEN, J.P. (1981). Increased adhesion of erythrocytes to endothelial cells in diabetes mellitus and its relation to vascular complications. New Engl. J. Med., 305, 237-242.