Structural analysis of p185c-neu and epidermal growth factor receptor tyrosine kinases: Oligomerization of kinase domains

Proceedings of the National Academy of Sciences of the United States of America

Volumn 93, Issue 13, 1996, Pages 6252-6257

  Murali, Ramachandran ^a   Brennan, Patrick J ^a   Kieber Emmons, Thomas ^a   Greene, Mark I ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Autophosphorylation; Enzyme structure function; Molecular modeling; Receptor dimerization

Indexed keywords

BIOPOLYMER; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; ONCOPROTEIN; PROTEIN TYROSINE KINASE;

AMINO ACID SEQUENCE; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; SEQUENCE HOMOLOGY; AUTOPHOSPHORYLATION; ENZYME ANALYSIS; ENZYME PHOSPHORYLATION; OLIGOMERIZATION; ONCOGENE NEU; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; BIOPOLYMERS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0029665883     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.93.13.6252     Document Type: Article

References (44)

1. Kokai, Y., Cohen, J. A., Drebin, J. A. & Greene, M. I. (1987) Proc. Natl. Acad. Sci. USA 84, 8498-8501.
2. Mori, S., Akiyama, T., Yamada, Y., Morishita, Y., Sugawara, I., Toyoshima, K. & Yamamoto, T. (1989) Lab. Invest. 61, 93-97.
3. Press, M. F., Cordon-Cardo, C. & Slammon, D. (1990) Oncogens 5, 953-962.
4. Ullrich, A. & Schlessinger, J. (1990) Cell 61, 203-212.
5. Schlessinger, J. (1988) Trends Biochem. Sci. 13, 443-447.
6. Lemmon, M. A. & Schlessinger, J. (1994) Trends Biochem. Sci. 19, 459-463.
7. Heldin, C. H. (1995) Cell 80, 213-223.
8. Weiner, D. B., Liu, J., Cohen, J. A., Williams, W. V. & Greene, M. I. (1989) Nature (London) 339, 230-231.
9. Weiner, D. B., Kokai, Y., Wada, T., Cohen, J. A., Williams, W. V. & Greene, M. I. (1989) Oncogens 4, 1175-1183.
10. Segatto, O., King, R. C., Pierce, J. H., Di Fiore, P. P. & Aaronson, S. A. (1988) Mol. Cell. Biol. 8, 5570-5574.
11. Goldman, R., Benlevy, R., Peles, E. & Yarden, Y. (1990) Biochemistry 29, 11024-11028.
12. Qian, X. L., Decker, S. J. & Greene, M. I. (1992) Proc. Natl. Acad. Sci. USA 89, 1330-1334.
13. Wada, T., Qian, X. & Greene, M. (1990) Cell 61, 1339-1347.
14. Qian, X., LeVea, C. M., Freeman, J. K., Dougall, W. C. & Greene, M. I. (1994) Proc. Natl. Acad. Sci. USA 91, 1500-1504.
15. Kokai, Y., Myers, J. N., Wada, T., Brown, V. I., LeVea, C. M., Davis, J. G., Dobashi, K. & Greene, M. I. (1989) Cell 58, 287-292.
16. Qian, X., Dougall, W. C., Hellman, M. E. & Greene, M. I. (1994) Oncogene 9, 1507-1514.
17. Higgins, D. G., Bleasby, A. J. & Fuchs, R. (1992) Comput. Appl. Biosci. 8, 189-191.
18. Knighton, D. R., Zheng, J. H., Ten, E. L. F., Ashford, V. A., Xuong, N. H., Taylor, S. S. & Sowadski, J. M. (1991) Science 253, 407-414.
19. Brünger, A. T. (1992) X-PLOR: A System for X-Ray Crystallography and NMR (Yale Univ. Press, New Haven, CT), Version 3.1.
20. Jones, T. A., Zou, J.-Y & Cowan, S. W. (1991) Acta Crystallogr. A 47, 110-119.
21. Nicholls, A., Sharp, K. A. & Honig, B. (1991) Proteins 11, 281-296.
22. Jones, T. A. & Thirup, S. (1986) EMBO J. 5, 819-822.
23. Blundell, T. L., Sibanda, B. L., Sternberg, M. J. & Thornton, J. M. (1987) Nature (London) 326, 347-352.
24. Ponder, J. W. & Richards, F. M. (1987) J. Mol. Biol. 193, 775-791.
25. Luthy, R., Bowie, J. U. & Eissenberg, D. (1992) Nature (London) 356, 83-85.
26. CCP4 (1994) Acta Crystallogr. D 50, 760-763.
27. Zheng, J., Knighton, D. R., Xuong, N. H., Taylor, S. S., Sowadski, J. M. & Ten, E. L. (1993) Protein Sci. 2, 1559-1573.
28. Myers, J. N., LeVea, C. M., Smith, J. E., Kallen, R. G., Tung, L. & Greene, M. I. (1992) Receptor 2, 1-16.
29. Knighton, D. R., Cadena, D. L., Zheng, J., Ten, E. L. F., Taylor, S. S., Sowadski, J. M. & Gill, G. N. (1993) Proc. Natl. Acad. Sci. USA 90, 5001-5005.
30. Janin, J. & Chothia, C. (1990) J. Biol. Chem. 265, 16027-16030.
31. Wodak, S. J., Crombrugghe, M. D. & Janin, J. (1987) Prog. Biophys. Mol. Biol. 49, 29-63.
32. Hanks, S. K., Quinn, A. M. & Hunter, T. (1988) Science 241, 42-52.
33. Zhang, F., Strand, A., Robbins, D., Cobb, M. H. & Goldsmith, E. J. (1994) Nature (London) 367, 704-711.
34. Hu, S. H., Parker, M. W., Lei, J. Y., Wilce, M. C., Benian, G. M. & Kemp, B. E. (1994) Nature (London) 369, 581-584.
35. Hubbard, S. R., Wei, L., Ellis, L. & Hendrickson, W. A. (1994) Nature (London) 372, 746-754.
36. Jones, S. & Thornton, J. M. (1995) Prog. Biophys. Mol. Biol. 63, 31-65.
37. Argos, P. (1988) Protein Eng. 2, 101-113.
38. Yarden, Y. & Schlessinger, J. (1987) Biochemistry 26, 1434-1442.
39. Downward, J., Parker, P. & Waterfield, M. D. (1984) Nature (London) 311, 483-485.
40. Dougall, W. C., Qian, X., Peterson, N. C., Miller, M. J., Samanta, A. & Greene, M. I. (1994) Oncogene 9, 2109-2123.
41. Sali, A., Overington, J. P., Johnson, M. S. & Blundell, T. L. (1990) Trends Biochem. Sci. 15, 235-240.
42. Samanta, A., LeVea, C. M., Dougall, W. C., Qian, X. & Greene, M. I. (1994) Proc. Natl. Acad. Sci. USA 91, 1711-1715.
43. Lax, I., Mitra, A. K., Ravera, C., Hurwitz, D. R., Rubinstein, M., Ullrich, A., Stroud, R. M. & Schlessinger, J. (1991) J Biol. Chem. 266, 13828-13833.
44. Cantley, L. C., Auger, K. R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller. R. & Soltoff S. (1991) Cell 64, 281-302.