δ-aminolevulinic acid dehydratase activity in weanling and adult rats exposed to lead acetate

Bulletin of Environmental Contamination and Toxicology

Volumn 57, Issue 1, 1996, Pages 47-53

  Rodrigues, A L S ^a   Rocha, J B T ^b   Pereira, M E ^b   Souza, D O ^c  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

LEAD ACETATE; PORPHOBILINOGEN SYNTHASE; LEAD; ORGANOMETALLIC COMPOUND;

ANIMAL EXPERIMENT; ARTICLE; ECOTOXICITY; ENVIRONMENTAL IMPACT ASSESSMENT; ENZYME ACTIVITY; ENZYME INHIBITION; LEAD POISONING; NEPHROTOXICITY; NEUROTOXICITY; NEWBORN; NONHUMAN; RAT; AGING; ANALYSIS OF VARIANCE; ANIMAL; ATOMIC ABSORPTION SPECTROMETRY; BLOOD; CEREBELLUM; COMPARATIVE STUDY; DRUG EFFECT; ENZYMOLOGY; FEMALE; FOREBRAIN; KIDNEY; MALE; METABOLISM; ORAL DRUG ADMINISTRATION; POLLUTANT; PREGNANCY; PRENATAL EXPOSURE; SUCKLING; TISSUE DISTRIBUTION; WEANING; WISTAR RAT;

ADMINISTRATION, ORAL; AGING; ANALYSIS OF VARIANCE; ANIMALS; ANIMALS, SUCKLING; CEREBELLUM; ENVIRONMENTAL POLLUTANTS; FEMALE; KIDNEY; LEAD; MALE; ORGANOMETALLIC COMPOUNDS; PORPHOBILINOGEN SYNTHASE; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PROSENCEPHALON; RATS; RATS, WISTAR; SPECTROPHOTOMETRY, ATOMIC; TISSUE DISTRIBUTION; WEANING;

ENZYME KINETICS; ENZYMES; HEALTH HAZARDS; INDUSTRIAL POISONS; NEUROLOGY; ORGANIC ACIDS; TOXICITY;

ADULT RATS; AMINOLEVULINATE; AMINOLEVULINIC ACID; BRAIN REACTIVATION INDEX; DEHYDRATASE ACTIVITY; ENVIRONMENTAL POLLUTANT; LEAD ACETATE; LEAD NEUROTOXICITY; LEAD POISONING; WEANLING;

LEAD COMPOUNDS;

EID: 0029665873     PISSN: 00074861     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001289900154     Document Type: Article

References (16)

1. Al-Saleh IAS (1994) The biochemical and clinical consequences of lead poisoning. Med Res Rev 14:415-486.
2. Bechara EJH, Medeiros MHG, Monteiro HP, Hermes-Lima M, Pereira B, Demasi, M, Costa CA, Abdalla DSP, Onuki J, Wendel CMA, Mascio P (1993) A free radical hypothesis of lead poisoning and inborn porphyrias associated with 5-aminolevulinic acid overload. Química Nova 16:385-392.
3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Choie DD, Richter GW (1974) Cell proliferation in mouse kidney induced by lead I. Synthesis of deoxyribonucleic acid. Lab Invest 30:647-651.
5. Davis JM, Otto DA, Weil DE, Grant LD (1990) The comparative developmental neurotoxicity of lead in humans and animals. Neurotoxicol Teratol 12:215-229.
6. Goering PL (1993) Lead-protein interactions as a basis for lead toxicity. NeuroToxicology 14:45-60.
7. Granick JL, Sassa S, Granick S, Levere RD, Kappas A (1973) Studies in lead poisoning II. Correlation between the ratio of activated to inactivated δ-aminolevulinic acid dehydratase of whole blood and the blood lead level. Biochem Med 8:149-159.
8. Hasan F, Cookman GR, Keane GJ, Bannigan JG, King WB, Regan CM (1989) The effect of low level lead exposure on the postnatal structuring of the rat cerebellum. Neurotoxicol Teratol 11:433-440.
9. Nolan CV, Shaikh ZA (1992) Lead nephrotoxicity and associated disorders: biochemical mechanisms. Toxicology 73:127-146.
10. Oskarsson A (1989) Effects of perinatal treatment with lead and disulfiram on ALAD activity in blood, liver and kidneys and urinary ALA excretion in rats. Pharmacol Toxicol 64:344-348.
11. Rocha JBT, Pereira ME, Emanuelli T, Christofari RS, Souza DO (1995) Effect of treatment with mercury chloride and lead acetate during the second stage of rapid postnatal brain growth on δ-aminolevulinic acid dehydratase activity in brain, liver, kidney and blood of suckling rats. Toxicology 100:27-37.
12. Rodrigues AL, Bellinaso ML, Dick T (1989) Effect of some metal ions on blood and liver delta-aminolevulinate dehydratase of Pimelodus maculatus (Pisces, Pimelodidae). Comp Biochem Physiol 94B:65-69.
13. Rodrigues ALS, Rubin MA, Souza DO, Mello CF (1993) Lead exposure and latent learning ability of adult female rats. Behav Neural Biol 60:274-279.
14. Sakai T, Yanagihara S, Ushio K (1980) Restoration of lead-inhibited 5-aminolevulinate dehydratase activity in whole blood by heat, zinc ion, and (or) dithiothreitol. Clin Chem 26:625-628.
15. Sassa S (1982) Delta-aminolevulinic acid dehydratase assay. Enzyme 28:133-145.
16. Simmonds PL, Luckhurst CL, Woods JS (1995) Quantitative evaluation of heme biosynthetic pathway parameters as biomarkers of low-level lead exposure in rats. J Toxicol Environ Health 44:351-367.