Effects of a topical antihistamine maleate and topical anaesthetics on iontophoretically induced itch;ANTIPRURITUGENER EFFEKT ANTIHISTAMINERGER UND LOKALANASTHETISCHER EXTERNA NACH IONTOPHORETISCHEM HISTAMINREIZ

Hautarzt

Volumn 47, Issue 5, 1996, Pages 355-360

  Weisshaar, E ^a,b   Heyer, G ^a,b   Forster, C ^a,b   Hornstein, O P ^a,b   Handwerker, H O ^a,b  

^a Dermatologische Universitatsklinik   (Germany)

^b NONE

Author keywords

alloknesis; antipruritic local therapy; local histamine effect; pruritus

Indexed keywords

DIMETINDENE; EMLA; HISTAMINE; LIDOCAINE; OPTIDERM; POLIDOCANOL; PRILOCAINE; UNCLASSIFIED DRUG; ANTIPRURITIC AGENT; HISTAMINE H1 RECEPTOR ANTAGONIST; LOCAL ANESTHETIC AGENT; MACROGOL DERIVATIVE;

AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; IONTOPHORESIS; MALE; NORMAL HUMAN; PRURITUS; TOPICAL DRUG ADMINISTRATION; ADULT; COMPARATIVE STUDY; DRUG EFFECT; HISTAMINE RELEASE; INNERVATION; MECHANORECEPTOR; MIDDLE AGED; PAIN THRESHOLD; PERCEPTIVE THRESHOLD; RANDOMIZED CONTROLLED TRIAL; SINGLE BLIND PROCEDURE; SKIN;

ADULT; ANESTHETICS, LOCAL; ANTIPRURITICS; DIMETHINDENE; FEMALE; HISTAMINE H1 ANTAGONISTS; HISTAMINE RELEASE; HUMANS; IONTOPHORESIS; LIDOCAINE; MALE; MECHANORECEPTORS; MIDDLE AGED; PAIN THRESHOLD; POLYETHYLENE GLYCOLS; PRILOCAINE; SENSORY THRESHOLDS; SINGLE-BLIND METHOD; SKIN;

EID: 0029665724     PISSN: 00178470     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001050050430     Document Type: Article

References (25)

1. Althaus MA (1992) Dimethindene maleate (Fenistilgel) in the control of itching due to insect bites and sunburns. The Histamine Research Society. Special Conference Issue
2. Bjerring P. Arendt-Nielsen L (1992) A quantitative comparison of the effect of local analgetics on argon laser induced cutaneous pain and on histamine induced wheat, flare and itch. Acta Derm Venereol 70126-131
3. Bjerring P, Andersen PH, Arendt-Nielsen L (1989) Vascular response of human skin after analgesia with EMLA cream. Br J Anaesth 63:655-660
4. Borelli S, Stüttgen G (1992) Neurodermitistherapie und Harnstoff. Hautarzt 43 [Suppl XI]: 1-29
5. De Waard-van der Spek FB. van den Berg GM, Oranje AP (1992) EMLA cream: an improved local anaesthetic: review of current literature. Pediatr Dermatol 9: 126-131
6. Dobozy A (1973) Die Resorption des Dimethindenum maleicum in der Rattenhaut. Z Hautkr 48:787-789
7. Guillerm R (1974) Prüfung der lokalen Antihistaminwirkung von dermatologischen Präparaten. Arzneimittel Forsch 24:1350
8. Handwerker HO (1993) Neurophysiologische Mechanismen des Juckens. H + G 68: 730-735
9. Handwerker HO (1992) Pain and allodynia, itch and alloknesis: an alternative hypothesis. APS Journal 1: 135-138
10. Hauss H, Proppe A, Matthies C (1993) Vergleichende Untersuchungen zur Behandlung von trockener, juckender Haut mit einer Zubereitung aus Harnstoff und Polidocanol sowie mit einer Linolsäurehaltigen Fettcreme. Dermatosen 41: 184-188
11. Humphreys F, Shuster S (1987) The effect of topical dimethindene maleate on wheal reaction. Br J Clin Pharmacol 23:234-236
12. Juhlin L, Evers H, Broberg F (1980) A lidocaine-prilocaine cream for superficial skin surgery and painful lesions. Acta Derm Venereol 60:544-546
13. LaMotte RH (1992) Subpopulations of "nocifensor neurons" contributing to pain and allodynia, itch and alloknesis. APS Journal 1: 115-126
14. Lever LR, Hill S, Dykes, PJ, Marks R (1991) Efficacy of topical dimetindene in experimentally induced pruritus and wheal and flare reactions. Skin Pharmacol 4: 109-112
15. Lycka BAS (1992) EMLA. A new and effective topical anaesthetic. J Dermatol Surg Oncol 18: 859-862
16. Puschmann M (1992) Experimentelle Untersuchungsergebnisse zur Juckreizlinderung, zur Hautfettung und Hautverträglichkeit einer Harnstoff- und Polidocanolhaltigen Zubereitung. Aktuel Dermatol 181: 224-227
17. Raab W (1989) Harnstoff in der Dermatologie. Hautarzt 40 [Suppl IX]: 1-19
18. Rampini E, Oberhauser V, Nunzi E (1978) Beurteilung der lokalen Antihistaminwirkung von Dimetindenmaleat mit Hilfe einer quantitativen Methode. Dermatologica 157: 105-109
19. Rohdewald P, Milsmann E (1986) Resorption von Antihistaminika aus Externa. Pharmazeutische Zeitung 131: 2035-2038
20. Schaffler K, Waschkuhn C, Brunnauer H, Rehn D (1992) Evaluation of the local anaesthetic activity of dimetindene maleat by means of laser algesimetry in healthy volunteers. Arzneimittelforschung 42: 1332-1335
21. Shuttleworth D, Hill S, Marks R, Conncly DM (1988) Relief of experimentally induced pruritus with a novel eutectic mixture of local anaesthetic agents. Br J Dermatol 119: 535-540
22. Simone DA, Alreja M, LaMotte R (1991) Psychophysical studies of the itch sensation and itchy skin ("Alloknesis") produced by intracutaneous injection of histamine. Somatosensory Motor Research 8:271-279
23. Swanbeck G, Rajka G (1972) Antipruritic effect of urea solution. Acta Derm Venereol 50: 225-227
24. Vieluf D, Matthies C, Ring J (1992) Trockene, juckende Haut - ihre Behandlung mit einer neuen Polidocanol-Harnstoff-Zubereitung. Z Hautkr 67: 816-821
25. Wohlrab W (1984) Vehikelabhängigkeit der Harnstoffpenetration in die menschliche Haut. Dermatologica 169: 53-59