Vitamin D3 treatment of tumor bearers can stimulate immune competence and reduce tumor growth when treatment coincides with a heightened presence of natural suppressor cells

Cancer Letters

Volumn 104, Issue 2, 1996, Pages 153-161

  Young, M Rita I ^a,b   Lozano, Yvonne ^a   Ihm, Joe ^a   Wright, Mark A ^a   Prechel, M Margaret ^b  

^a HINES VA HOSPITAL   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Immunosuppressor cells; Suppressor cells; Tumor; Vitamin D3

Indexed keywords

COLECALCIFEROL; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMMUNOLOGICAL ADJUVANT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; IMMUNOCOMPETENCE; INTRAPERITONEAL DRUG ADMINISTRATION; LEWIS CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUPPRESSOR CELL; TUMOR IMMUNITY; ANIMAL; C57BL MOUSE; CELL DIVISION; DRUG EFFECT; HEMATOPOIETIC STEM CELL; IMMUNOLOGY; LYMPH NODE; PATHOLOGY; PHYSIOLOGY; REGULATORY T LYMPHOCYTE;

ANIMALIA;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; CARCINOMA, LEWIS LUNG; CELL DIVISION; CHOLECALCIFEROL; HEMATOPOIETIC STEM CELLS; LYMPH NODES; MICE; MICE, INBRED C57BL; T-LYMPHOCYTES, REGULATORY;

EID: 0029665697     PISSN: 03043835     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3835(96)04241-3     Document Type: Article

References (44)

1. Vujanovic, N.L., Yasumura, S., Hirabayashi, H., Lin, W., Watkins, S., Herberman, R.B. and Whiteside, T.L. (1995) Antitumor activities of subsets of human IL-2-activated natural killer cells in solid tissues. J. Immunol., 154, 281-289.
2. + helper/killer T cell phenomenon. Selective induction of Th1 helper/killer T cells and application to tumor immunotherapy. J. Immunol., 154, 1777-1785.
3. Cox, G.W., Melillo, G., Chattopadhyay, U., Mullet, D., Fertel, R.H. and Varesio, L. (1992) Tumor necrosis factor-α-dependent production of reactive nitrogen intermediates mediates IFN-γ plus IL-2-induced murine macrophage tumoricidal activity. J. Immunol., 149, 3290-3296.
4. Alleva, D.G., Burger, C.J. and Elgert, K.D. (1994) Tumour growth causes suppression of autoreactive T-cell proliferation by disrupting macrophage responsiveness to interferon-γ. Scand. J. Immunol., 39, 31-38.
5. Alexander, J.P., Kudoh, S., Melsop, K.A., Hamilton, T.A., Edinger, M.G., Tubbs, R.R., Sica, D., Tuason, L., Klein, E., Budowski, R.M. and Finke, J.H. (1993) T-cells infiltrating renal cell carcinoma display a poor proliferative response even though they can produce interleukin 2 and express interleukin 2 receptors. Cancer Res., 53, 1380-1387.
6. Mizoguchi, H., O'Shea, J.J., Longo, D.L., Loeffler, C.M., McVicar, D.W. and Ochoa, A.C. (1992) Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science, 258, 1795-1798.
7. Yoshino, I., Yano, T., Murata, M., Ishida, T., Sugimachi, K. and Kimura, G. (1992) Tumor-reactive T-cells accumulate in lung cancer tissues but fail to respond due to tumor cell-derived factor. Cancer Res., 52, 775-781.
8. Prechel, M.M., Lozano, Y., Wright, M.A., Ihm, J. and Young, M.R.I. (1995) Ineffective immune enhancement by IL-12 in tumor-bearing mice whose immune depression is mediated by suppressive granulocyte-macrophage progenitor cells. Cancer Lett., 92, 235-242.
9. Alleva, D.G., Walker, T.M. and Elgert, K.D. (1995) Induction of macrophage suppressor activity by fibrosarcoma-derived transforming growth factor-β1: contrasting effects on resting and activated macrophages. J. Leukocyte Biol., 57, 919-928.
10. 2. J. Immunol., 153, 1674-1686.
11. Maeda, N. and Sagara, Y. (1993) Analysis of immunosuppressive mechanism to cytotoxic T lymphocyte generation in patients with advanced cancer. Asia-Oceana J. Obstet. Gynaecol., 19, 309-318.
12. Sahasrabudhe, D.M. and Dusel, J.C. (1994) Effect of murine interferon alpha/beta on tumour-induced suppressor function. Cancer Immunol. Immunother., 39, 360-366.
13. Inge, T.H., Hoover, S.K., Frank, J.L., Kawabata, T.T., Bethke, K.P. and Bear, H.D. (1992) Enhancement of cytotoxic T lymphocyte growth from spleens of P815-tumor-bearing host mice with mafosfamide. Cancer Immunol. Immunother., 35, 119-126.
14. Koyama, S. and Fukao, K. (1994) Phenotypic analysis of nylon-wool-adherent suppressor cells that inhibit the effector process of tumour cell lysis by lymphokine-activated killer cells in patients with advanced gastric carcinoma. J. Cancer Res. Clin. Oncol., 120, 240-247.
15. Young, M.R.I., Wright, M.A., Matthews, J.P., Malik, I. and Prechel, M. (1996) Suppression of T cell proliferation by tumor-induced granulocyte-macrophage progenitor cells producing transforming growth factor-β and nitric oxide. J. Immunol., 156, in press.
16. + cells in cancers that secrete granulocyte-macrophage colony-stimulating factor. Clin. Cancer Res., 1, 95-103.
17. 2-dependent and -independent immune suppressor cells by tumor-derived GM-CSF and M-CSF. J. Leukocyte Biol., 53, 86-92.
18. Schmidt-Wolf, I.G., Dejbakhsh-Jones, S., Ginzton, N., Greenberg, P. and Strober, S. (1992) T-cell subsets and suppressor cells in human bone marrow. Blood, 80, 3242-3250.
19. Angulo, I., Rodriguez, R., Garcia, B., Medina, M., Navarro, J. and Subiza, J.L. (1995) Involvement of nitric oxide in bone marrow-derived natural suppressor activity. Its dependence on IFN-γ. J. Immunol., 155, 15-26.
20. Field, E.H. and Becker, G.C. (1992) Blocking of mixed lymphocyte reaction by spleen cells from total lymphoid-irradiated mice involves interruption of the IL-2 pathway. J. Immunol., 148, 354-359.
21. Moore, S.C., Theus, S.A., Barnett, J.B. and Soderberg, L.S. (1992) Cytokine regulation of bone marrow natural suppressor cell activity in the suppression of lymphocyte function. Cell. Immunol., 141, 398-408.
22. + natural suppressor cells on IL-2 and IL-4 utilization in MLR. Transplantation, 58, 1096-1103.
23. Young, M.R.I. and Wright, M.A. (1992) Myelopoiesis-associated immune suppressor cells in mice bearing metastatic Lewis lung carcinoma tumors: interferon-γ plus tumor necrosis factor-α synergistically reduce immune suppressor and tumor growth-promoting activities of bone marrow cells, and diminish tumor recurrence and metastasis. Cancer Res., 52, 6335-6340.
24. Joraschkewitz, M., Depenbrock, H., Freund, M., Erdmann, G., Meyer, H.-J., De Riese, W., Neukam, D., Hanauske, U., Krumwieh, M., Poliwoda, H. and Hanauske, A.-R. (1992) Effects of cytokines on in vitro colony formation of primary human tumour specimens. Eur. J. Cancer, 26, 1070-1074.
25. Pavel, P., Halapi, E., Pisa, E.K., Gerdin, E., Rising, C., Bucht, A., Gerdin, B. and Kiessling, R. (1992) Selective expression of interleukin 10, interferon γ, and granulocyte-macrophage colony-stimulating factor in ovarian cancer biopsies. Proc. Natl. Acad. Sci. USA, 89, 7708-7712.
26. Lang, S.H., Miller, W.R., Duncan, W. and Habib, F.K. (1994) Production and response of human prostate cancer cell lines to granulocyte macrophage-colony stimulating factor. Int. J. Cancer, 59, 235-241.
27. 3 plus γ-interferon blocks lung tumor production of granulocyte-macrophage colony-stimulating factor and induction of immunosuppressor cells. Cancer Res., 53, 6006-6010.
28. Sawyers, C.L., Golde, D.W., Quan, S. and Nimer, S.D. (1992) Production of granulocyte-macrophage colony-stimulating factor in two patients with lung cancer, leukocytosis, and eosinophilia. Cancer, 69, 1342-1346.
29. Berdel, W.E., Danhauser-Riedl, S., Oberberg, D. and Zafferani, M. (1992) Effects of hematopoietic growth factors on malignant nonhematopoietic cells. Semin. Oncol., 19, 41-45.
30. Duffie, G.P. and Young, M.R.I. (1991) Tumoricidal activity of alveolar and peritoneal macrophages of C57B1/6 mice bearing metastatic or nonmetastatic variants of Lewis lung carcinoma. J. Leukocyte Biol., 49, 8-14.
31. Young, M.R. and Young, M.E. (1989) Effects of fish oil diets on prostaglandin-dependent and myelopoiesis-associated immune suppressor mechanisms of mice bearing metastatic Lewis lung carcinoma tumors. Cancer Res., 49, 1931-1936.
32. Schmidt-Pak, A., Ip, G., Wright, M.A. and Young, M.R.I. (1995) Treating tumor-bearing mice with low dose interferon-γ plus tumor necrosis factor-α to diminish immune suppressive granulocyte-macrophage progenitor cells increases responsiveness to IL-2 immunotherapy. Cancer Res., 55, 885-890.
33. 3, but not cyclosporine A, inhibit production of granulocyte-macrophage colony-stimulating factor in human fibroblasts. Blood, 77, 1912-1918.
34. 3 reduces tumor motility and metastasis. Invas. Metast., 13, 169-177.
35. 3 diminishes tumor-induced myelopoiesis and associated immune suppression, and reduces tumor metastasis and recurrence. Cancer Immunol. Immunother., 41, 37-45.
36. 3 prevents insulitis in NOD mice. Diabetes, 41, 1491-1495.
37. + tumor-infiltrating lymphocytes after eliminating immune suppressive granulocyte-macrophage progenitor cells with low doses of interferon-γ plus tumor necrosis factor-α. Cancer Immunol. Immunother., 38, 9-15.
38. Manolagas, S.C., Yu, X.P., Girasole, G. and Bellido, T. (1993) Vitamin D and the hematolymphopoietic tissue: a 1994 update. Semin. Nephrol., 14, 129-143.
39. 3. J. Steroid Biochem. Mol. Biol., 53, 599-602.
40. 3. Vet. Immunol. Immunopathol., 38, 75-89.
41. Yang, S., Smith, C., Prahl, J.M., Luo, X. and DeLuca, H.F. (1993) Vitamin D deficiency suppresses cell-mediated immunity in vivo. Arch. Biochem. Biophys., 303, 98-106.
42. 3 increases type 1 interleukin-1 receptor expression in a murine T cell line. J. Cell. Biochem., 52, 159-170.
43. 3 induce on THP-1 cells distinct patterns of cell surface antigen expression, cytokine production, and responsiveness to contact with activated T-cells. J. Immunol., 149, 2040-2046.
44. 3. Blood, 80, 2811-2816.