Cationic [99mTcIII(DIARS)2(SR)2]+ complexes as potential myocardial perfusion imaging agents (DIARS = o-phenylenebis(dimethylarsine); SR- = thiolate)

Journal of Medicinal Chemistry

Volumn 39, Issue 6, 1996, Pages 1253-1261

  Tisato, Francesco ^a   Maina, Theodosia ^e   Shao, Li Ren ^d   Heeg, Mary Jane ^c   Deutsch, Edward ^b  

^a Ist Chim Tecnologie Inorganiche M   (Italy)

^b MALLINCKRODT PHARMACEUTICALS   (United States)

^c WAYNE STATE UNIVERSITY   (United States)

^d Isotec Inc   (United States)

^e NONE

Author keywords

[No Author keywords available]

Indexed keywords

1,2 PHENYLENEBIS(DIMETHYLARSINE); ARSINE DERIVATIVE; CATION; ETHER; RADIOPHARMACEUTICAL AGENT; TECHNETIUM 99M; THIOL DERIVATIVE; UNCLASSIFIED DRUG; DIAGNOSTIC AGENT; LIGAND; TECHNETIUM COMPLEX;

ANIMAL EXPERIMENT; ANIMAL TISSUE; COMPLEX FORMATION; DRUG DISTRIBUTION; DRUG STRUCTURE; DRUG SYNTHESIS; FAST ATOM BOMBARDMENT MASS SPECTROMETRY; FEMALE; HEART MUSCLE PERFUSION; HEART SCINTISCANNING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; RAT; REVIEW; TISSUE DISTRIBUTION; ANIMAL; ARTICLE; HEART; OXIDATION REDUCTION REACTION; PH; SCINTISCANNING; SPRAGUE DAWLEY RAT;

ANIMALS; FEMALE; HEART; HYDROGEN-ION CONCENTRATION; LIGANDS; ORGANOTECHNETIUM COMPOUNDS; OXIDATION-REDUCTION; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION;

EID: 0029665587     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9507789     Document Type: Article

References (34)

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16. (a) Jurisson, S.; Dancey, K.; McPartlin, M.; Tasker, P. A.; Deutsch, E. Synthesis, Characterization and Electochemieal Properties of Technetium Complexes Containing Both Tetradentate Schiff Base and Monodentate Tertiary Phosphine Ligands: Single Crystal Structure of trans-(N.N-ethylenebis(acetylacetoneiminato))bis-(triphenylphosphine) Technetium(III) Hexafluororphosphate. Inorg. Chem. 1984, 23, 4743-4749.
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33. 2 was removed by evaporation at reduced pressure, and the resulting deep red liquid was diluted to give a 33% aqueous solution that can be used within 1 week when stored at room temperature.
34. +. See ref 2b.