The Q10 ratio for basal cerebral metabolic rate for oxygen in rats

Journal of Neurosurgery

Volumn 85, Issue 3, 1996, Pages 482-487

  Klementavicius, Richard ^a   Nemoto, Edwin M ^a,b   Yonas, Howard ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

barbiturates; cerebral blood flow; cerebral metabolic rate for oxygen; cerebral metabolism; hypothermia; rat

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BRAIN BLOOD FLOW; BRAIN OXYGEN CONSUMPTION; CONTROLLED STUDY; INDUCED HYPOTHERMIA; MALE; METABOLIC RATE; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; BRAIN; BRAIN CIRCULATION; METABOLISM; PHYSIOLOGY; THERMOREGULATION; WISTAR RAT;

OXYGEN;

ANIMALS; BODY TEMPERATURE REGULATION; BRAIN; CEREBROVASCULAR CIRCULATION; MALE; OXYGEN; RATS; RATS, WISTAR;

EID: 0029665504     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.1996.85.3.0482     Document Type: Article

References (28)

1. Astrup J, Sørensen PM, Sørensen HR: Oxygen and glucose consumption related to Na+-K+ transport in canine brain. Stroke 12:726-730, 1981
2. Bering EA Jr: Effect of body temperature change on cerebral oxygen consumption of the intact monkey. Am J Physiol 200: 417-419, 1961
3. Busto R, Dietrich WD, Globus MYT, et al: Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 7: 729-738, 1987
4. Clark R, Schiding J, White M, et al: Posttraumatic hypothermia decreases mortality after severe controlled cortical impact in rats. Crit Care Med 23 (Suppl):A74, 1995 (Abstract)
5. Cohen PJ, Wollman H, Alexander SC, et al: Cerebral carbohydrate metabolism in man during halothane anesthesia. Effects of Paco, on some aspects of carbohydrate utilization. Anesthesiology 25:185-191, 1964
6. Gjedde A, Caronna JJ, Hindfelt B, et al: Whole-brain blood flow and oxygen metabolism in the rat during nitrous oxide anesthesia. Am J Physiol 229:113-118, 1975
7. Greeley WJ, Ungerleider RM, Quill T, et al: The effects of hypothermic cardiopulmonary bypass and total circulatory arrest on cerebral metabolism in neonates, infants, and children. J Thorac Cardiovasc Surg 101:783-794, 1991
8. Hagerdäl M, Harp J, Nillson L, et al: The effect of induced hypothermia upon oxygen consumption in the rat brain. J Neurochem 24:311-316, 1975
9. Lafferty JJ, Keykhah MM, Shapiro HM, et al: Cerebral hypometabolism obtained with deep pentobarbital anesthesia and hypothermia (30° C). Anesthesiology 49:159-161, 1978
10. Lazenby WD, Ko W, Zelano JA, et al: Effects of temperature and flow rate on regional blood flow and metabolism during cardiopulmonary bypass. Ann Thorac Surg 53:957-964, 1992
11. Michenfelder JD: The interdependency of cerebral functional and metabolic effects following massive doses of thiopental in the dog. Anesthesiology 41:231-236, 1974
12. Michenfelder JD, Milde JH: The relationship among canine brain temperature, metabolism and function during hypothermia. Anesthesiology 75:130-136, 1991
13. Michenfelder JD, Theye RA: Hypothermia. Effect on canine brain and whole-body metabolism. Anesthesiology 29: 1107-1112, 1968
14. Milde LN: Clinical use of mild hypothermia for brain protection: a dream revisited. J Neurosurg Anesthes 4:211-215, 1992
15. Minamisawa H, Nordström CH, Smith ML, et al: The influence of mild body and brain hypothermia on ischemic brain damage. J Cereb Blood Flow Metab 10:365-374, 1990
16. Mutch WAC, Sutton IR, Teskey JM, et al: Cerebral pressure-flow relationship during cardiopulmonary bypass in the dog at normothermia and moderate hypothermia. J Cereb Blood Flow Metab 14:510-518, 1994
17. Nemoto EM, Klementavicius R, Melick J: Effect of mild hypothermia on active and basal cerebral oxygen metabolism and blood flow. Adv Exp Med Biol 361:469-473, 1994
18. Nemoto EM, Yao L, Yonas H, et al: Active and basal whole brain blood flow, oxygen and glucose metabolism in monkeys. Adv Exp Med Biol 317:695-698, 1992
19. Rosomoff HL, Holaday DA: Cerebral blood flow and cerebral oxygen consumption during hypothermia. Am J Physiol 179: 85-88, 1954
20. Sano T, Drummond JC, Patel PM, et al: A comparison of the cerebral protective effects of isoflurane and mild hypothermia in a model of incomplete forebrain ischemia in the rat. Anesthesiology 76:221-228, 1992
21. Shiozaki T, Sugimoto H, Taneda M, et al: Effect of mild hypothermia on uncontrollable intracranial hypertension after severe head injury. J Neurosurg 79:363-368, 1993
22. Siesjo BK: Brain Energy Metabolism. New York: John Wiley, 1978
23. Singh NC, Kochanek PM, Schiding JK, et al: Uncoupled cerebral blood flow and metabolism after severe global ischemia in rats. J Cereb Blood Flow Metab 12:802-808, 1992
24. Steen PA, Newberg L, Milde JH. et al: Hypothermia and barbiturates: individual and combined effects on canine cerebral oxygen consumption. Anesthesiology 58:527-532, 1983
25. Stone HH, Donnelly C, Frobese AS: The effect of lowered body temperature on the cerebral hemodynamics and metabolism of man. Surg Gynecol Obstet 103:313-317, 1956
26. Todd MM, Warner DS: A comfortable hypothesis reevaluated. Cerebral metabolic depression and brain protection during ischemia. Anesthesiology 76:161-164, 1992
27. Weinrauch V, Safar P, Tisherman S, et al: Beneficial effect of mild hypothermia and detrimental effect of deep hypothermia after cardiac arrest in dogs. Stroke 23:1454-1462, 1992
28. Woodcock TE, Murkin JM, Farrar JK, et al: Pharmacologic EEG suppression during cardiopulmonary bypass: cerebral hemodynamic and metabolic effects of thiopental or isoflurane during hypothermia and normothermia. Anesthesiology 67: 218-224, 1987