Developmental and Evolutionary Aspects of Thymic T Cell Education to Neuroendocrine Self

Acta Haematologica

Volumn 95, Issue 3-4, 1996, Pages 263-267

  Geenen, Vincent ^a   Benhida, Abdellah ^b   Kecha, Ouafae ^a   Achour, Imane ^a   Vandersmissen, Eric ^a   Vanneste, Yves ^a   Goxe, Béatrice ^a   Martens, Henri ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b UNIVERSITY OF LIÈGE   (Belgium)

Author keywords

Cryptocrine signaling; Neuroendocrine self antigens; T cell tolerance; Thymus epithelium

Indexed keywords

ANTIGEN; AUTOANTIGEN; NEUROPHYSIN; OXYTOCIN; PROTEIN PRECURSOR; IMMUNOREACTIVE INSULIN; NEUROHYPOPHYSIS HORMONE; T LYMPHOCYTE RECEPTOR; TACHYKININ;

ANIMAL; GENETICS; HUMAN; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; MAJOR HISTOCOMPATIBILITY COMPLEX; METABOLISM; MOLECULAR EVOLUTION; NEUROSECRETION; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE; THYMUS; CELL COMMUNICATION; CONFERENCE PAPER; EPITHELIUM CELL; EVOLUTION; IMMUNOREACTIVITY; NEUROENDOCRINE SYSTEM; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIGENS; AUTOANTIGENS; EVOLUTION, MOLECULAR; HUMANS; MAJOR HISTOCOMPATIBILITY COMPLEX; NEUROPHYSINS; NEUROSECRETORY SYSTEMS; OXYTOCIN; PROTEIN PRECURSORS; SELF TOLERANCE; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; THYMUS GLAND;

EID: 0029665202     PISSN: 00015792     EISSN: 14219662     Source Type: Journal    
DOI: 10.1159/000203894     Document Type: Article

References (27)

1. Acher R: Neurohypophysial peptide systems: Processing machinery, hydroosmotic regulation, adaptation and evolution. Regul Pcpt 1993;45:1-13.
2. Gainer H, Wray S: Cellular and molecular biology of oxytocin and vasopressin; in Knobil E, Neill JD (eds): The Physiology of Reproduction, ed 2. New York. Raven, 1994, p 1099— 1129.
3. Breslow E: Chemistry' and biology of the neuro-physins. Annu Rev Biochem 1979;48:251-274.
4. Geenen V, Legros JJ, Franchimont P, Baudri-haye M, Dcfresne MP, Boniver J: The neuroendocrine thymus: Coexistence of oxytocin and neurophysin in the human thymus. Science 1986;232:508-511.
5. Geenen V, Legros JJ, Franchimont P, Dcfresnc MP, Boniver J, I veil R, Richter D: The thymus as a neuroendocrine organ: Synthesis of vasopressin and oxytocin in human thymic epithelium. Ann NY Acad Sci 1987;496:56-66.
6. Geenen V, Defresne MP, Robert F, Legros JJ, Franchimont P, Boniver J: The neurohormonal thymic microenvironment: Immunocytochem-ical evidence that thymic nurse cells are neuroendocrine cells. Neuroendocrinology 1988; 47:365-368.
7. Geenen V, Vandersmissen E, Martens H, Goxe B, Kecha O, Legros JJ, Lefebvre PJ, Benhida A, Rentier-Delrue F, Martial J: Cellular and molecular aspects of thymic T-cell education to neurohypophysial principles; in Saito T, Yoshi-da S, Imura H (eds): Proceedings of the First Joint World Congress on Neurohypophysis and Vasopressin. Amsterdam, Elsevier, in press.
8. Geenen V, Robert F, Martens H, Benhida A, Degiovanni G, Defresne MP, Boniver J, Legros JJ, Martial J, Franchimont P: Biosynthesis and paracrine/cryptocrine actions of ‘self neurohy-pophysial-related peptides in the thymus. Mol Cell Endocrinol 1991;76:C27-C31.
9. Wiemann M, Ehret G: Subcellular localization of immunoreactive oxytocin within thymic epithelial cells of the male mouse. Cell Tissue Res 1993;273:79-87.
10. Funder JW: Paracrine, cryptocrine, acrocrine. Mol Cell Endocrinol 1990;70:C21-C24.
11. Martens H, Robert F, Legros JJ, Geenen V, Franchimont P: Expression of functional neurohypophysial peptide receptors by murine immature and cytotoxic T-cell lines. Prog Ncu-roendocrinimmunol 1992;5:31-39.
12. Kruisbeek A: Development of a3 T cells. Curr Opin Immunol 1993;5:227-234.
13. Rammensee HG, Falk K, Rotzschke O: Peptides naturally presented by MHC class I molecules. Annu Rev Immunol 1993,11:213-244.
14. Gccncn V, Vandersmissen E, Cormann-Goffin N, Martens H, Legros JJ, Degiovanni G, Benhida A, Martial JA, Franchimont P: Membrane translocation and relationship with MHC class I of a human thymic neurophysin-like protein. Thymus 1993;22:55-66.
15. Imura H, Nakao K, Shimatsu A, Ogawa Y, Sando T, Fujisawa I, Yamabe H: Lymphocytic infundibuloneurohypophysitis as a cause of central diabetes insipidus. N Engl J Med 1993; 329:683-689.
16. Geenen V, Achour I, Robert F, Vandersmissen E, Sodoyez JC, Defresne MP, Boniver J, Lefebvre PJ, Franchimont P: Evidence that insu-lin-likc growth factor II (IGF-II) is the dominant thymic peptide of the insulin superfamily. Thymus 1993;21:115-127.
17. Ando S, McPhie P, Chaiken IM: Sequence redesign and the assembly mechanism of the oxytocin/bovine neurophysin I biosynthetic precursor. J Biol Chem 1987;262:12962-12969.
18. Chen L, Rose JP, Breslow' E, Yang D, Chang WR, Furey WF Jr., Sax M, Wang BC: Crystal structure of a bovine neurophysin II dipeptide complex at 2.8A determined from the singlewavelength anomalous scattering signal of an incorporated iodine atom. Proc Natl Acad Sci USA 1991;88:4240-4244.
19. Geenen V, Wiemann M, Martens H: Thymus gland: Neuroendocrin-Immunology; in Adel-man G, Smith B (eds): Encyclopedia of Neuroscience, ed 2. New' York, Elsevier, in press.
20. Bartl S, Baltimore D, Weissman IL: Molecular evolution of the vertebrate immune system. Proc Natl Acad Sci USA 1994;91:10769-10771.
21. Capra JD, Cheng KW, Friesen HG, North WG, Walter R: Evolution of neurophysin proteins: The partial sequence of human neuro-physin-I. FEBS Lett 1974;46:71-74.
22. Geenen V, Martens H, Robert F, Vrindts-Gevaert Y, De Groote D, Franchimont P: Immunomodulatory' properties of cyclic hexapep-tide oxytocin antagonists. Thymus 1992;20: 217-226.
23. Ericsson A, Geenen V, Robert F, Legros JJ, Vrindts-Gevaert Y, Franchimont P, Brene S, Persson H: Expression of preprotachykinin A and neuropeptide-Y messenger RNA in the thymus. Mol Endocrinol 1990;4:1211-1218.
24. Kramer S, Reynolds FH Jr., Castillo M, Valenzuela DM, Thorikay M, Sorvillo JM: Immunological identification and distribution of parathyroid hormone-like protein polypeptide in normal and malignant tissues. Endocrinologv 1991.128:1927-1937.
25. Bulloch K, McEwen BS, Diwa A, Baird S: Relationship between dehydroepiandrostcrone and calcitonin-gene related peptide in the mouse thymus. Am J Physiol 1995;268:E168—El72.
26. Vollmar AM, Shulz R: Atrial natriuretic peptide is synthesized in the human thymus. Endocrinology 1990;126:2277-2281.
27. Vollmar A, Wolf R, Schulz R: Co-expression of the natriuretic peptides (ANP, BNP, CNP) and their receptors in normal and acutely involuted rat thymus. J Neuroimmunol 1995:57:117-127.