Metallothionein-I-transgenic mice are not protected from acute cadmium-metallothionein-induced nephrotoxicity

Toxicology and Applied Pharmacology

Volumn 137, Issue 2, 1996, Pages 307-315

  Liu, Yaping ^a   Liu, Jie ^a   Palmiter, Richard D ^a,b   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUS MUSCULUS;

CADMIUM BINDING PROTEIN; CADMIUM-BINDING PROTEIN; METALLOTHIONEIN; CADMIUM; PROTECTIVE AGENT; ZINC;

ANIMAL; ARTICLE; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; DOSE RESPONSE; GENETICS; GLUCOSURIA; KIDNEY; KIDNEY DISEASE; MALE; METABOLISM; MOUSE; PHYSIOLOGY; PROTEINURIA; TRANSGENIC MOUSE; URINE; ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; KIDNEY TUBULE NECROSIS; NEPHROTOXICITY; NONHUMAN; PROTEIN URINE LEVEL; SUBCUTANEOUS DRUG ADMINISTRATION;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOSURIA; KIDNEY; KIDNEY DISEASES; MALE; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; PROTEINURIA;

EID: 0029665032     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0085     Document Type: Article

References (39)

1. Angerer, L. M., Cox, K. H., and Angerer, R. C. (1987). Demonstration of tissue-apecific gene expression by in situ hybridization. Methods Enzymol. 152, 649-661.
2. Bauman, J. W., Liu, J., and Klaassen, C. D. (1993). Production of metallothionein and heat-shock proteins in response to metals. Fundam. Appl. Toxicol. 21, 15-22.
3. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein binding. Anal. Biochem. 72, 248-254.
4. Chan, H. M., Zhu, L. F., Zhong, R., Grant, D., Goyer, R. A., and Cherian, M. G. (1993). Nephrotoxicity in rats following liver transplantation from cadmium-exposed rats. Toxicol. Appl. Pharmacol. 123, 89-96.
5. Cherian, M. G., Goyer, R. A., and Delaquerriere-Richardson, L. (1976). Cadmium - metallothionein-induced nephropathy. Toxicol. Appl. Pharmacol. 38, 399-408.
6. Chvapil, M. (1973). New aspects in the biological role of zinc: A stabilizer of macromolecules and biological membranes. Life Sci. 13, 1041-1049.
7. 109CdMT. Toxicol. Appl. Pharmacol. 114, 173-181.
8. Dorian, C., Gattone, V. H., II, and Klaassen C. D. (1992b). Accumulation and degradation of the protein moiety of cadmium - metallothionein (CdMT) in the mouse kidney. Toxicol. Appl. Pharmacol. 117, 242-248.
9. Dorian, C., Gattone, V. H., II, and Klaassen C. D. (1995). Discrepancy between the nephrotoxic potencies of cadmium - metallothionein and cadmium chloride and the renal concentration of cadmium in proximal convoluted tubules. Toxicol. Appl. Pharmacol. 130, 161-168.
10. Dorian, C., and Klaassen C. D. (1995). Protection by zinc - metallothionein (ZnMT) against cadmium - metallothionein-induced nephrotoxicity. Fundam. Appl. Toxicol. 26, 99-106.
11. Dudley, R. E., Gammal, L. M., and Klaassen, C. D. (1985). Cadmium-induced hepatic and renal injury in chronically exposed rats: Likely role of hepatic cadmium - metallothionein in nephrotoxicity. Toxicol. Appl. Pharmacol. 77, 414-426.
12. Eaton, D. L., and Toal, B. F. (1982). Evaluation of the Cd/hemoglobin affinity assay for the rapid determination of metallothionein in biological tissues. Toxicol. Appl. Pharmacol. 66, 134-142.
13. Fowler, B. A., Mistry, P., and Goering, P. L. (1987). Mechanism of metal-induced nephrotoxicity. In Nephrotoxicity in the Experimental and Clinical Situation (P. H. Bach and E. A. Lock, Eds.), pp. 659-681. Martinus -Nijhoff, Norwell, MA.
14. Goering, P. L., and Klaassen, C. D. (1983). Altered subcellular distribution of cadmium following cadmium pretreatment: Possible mechanism of tolerance to cadmium-induced lethality. Toxicol. Appl. Pharmacol. 70, 195-203.
15. Goering, P. L., and Klaassen, C. D. (1984). Zinc-induced tolerance to cadmium hepatotoxicity. Toxicol. Appl. Pharmacol. 74, 299-307.
16. Goyer, R. A., Miller, C. R., Shi-Ya, Z., and Victery, W. (1989). Nonmetallothionein-bound cadmium in the pathogenesis of cadmium nephrotoxicity in the rat. Toxicol. Appl. Pharmacol. 101, 232-244.
17. Iszard, M. B., Liu, J., Madhu, C., Liu, Y. P., and Klaassen, C. D. (1995a). Effect of several metallothionein inducers on oxidative stress defense mechanisms in rats. Toxicology 104, 25-33.
18. Iszard, M. B., Liu, J., Liu, Y. P., Dalton, T., Andrews, G. K., Palmiter, R. D., and Klaassen, C. D. (1995b). Characterization of metallothionein-I transgenic mice. Toxicol. Appl. Pharmacol. 133, 305-312.
19. Jin, T., Nordberg, G. F., and Nordberg, M. (1987). Resistance to acute nephrotoxicity induced by cadmium-metallothionein dependence on pretreatment with cadmium chloride. Pharmacol. Toxicol. 61, 89-93.
20. Jin, T., Nordberg, M., and Nordberg, G. F. (1992). Modulation of calciuria by cadmium pretreatment in rats with cadmium-metallothionein-induced nephrotoxicity. Toxicology 75, 29-37.
21. Kägi, J. H. R. (1993). Evolution, structure and chemical activity of class I metallothioneins: An overview. In Metallothionein III: Biological Roles and Medical Implications (K. T. Suzuki, N. Imura, and M. Kimura, Eds.), pp. 29-56. Birkhauser Verlag, Berlin.
22. Liu, X. Y., Jin, T. Y., Nordberg, G. F., Rännar, S., Sjöström, M., and Zhou, Y. (1992). A multivariate study of protective effects of Zn and Cu against nephrotoxicity induced by cadmium metallothionein in rats. Toxicol. Appl. Pharmacol. 114, 239-245.
23. Liu, X. J., Squibb, K. S., Akkerman, M., Fowler, B. A., Nordberg, G., and Lipsky, M. (1995a). Cytotoxicity, zinc protection and stress protein induction in rats proximal tubule cells exposed to cadmium chloride in primary cell culture. Toxicologist 15, 1601.
24. Liu, Y. P., Liu, J., Iszard, M. B., Andrews, G. K., Palmiter, R. D., and Klaassen, C. D. (1995b). Transgenic mice that overexpress metallothionein-I are protected from cadmium lethality and hepatotoxicity. Toxicol. Appl. Pharmacol. 135, 222-228.
25. Liu, J., Liu, Y. P., Michalska, A. E., Choo, K. H. A., and Klaassen, C. D. (1996). Metallothionein plays less of a protective role in cadmium -metallothionein-induced nephrotoxicity than in cadmium-chloride-induced hepatotoxicity. J. Pharmacol. Exp. Ther., in press.
26. Maitani, T., Cuppage, F. E., and Klaassen, C. D. (1988). Nephrotoxicity of intravenously injected cadmium - metallothionein: Critical concentration and tolerance. Fundam. Appl. Toxicol. 10, 98-108.
27. Masters, B. A., Kelly, E. J., Quaife, C. J., Brinster, R. L., and Palmiter, R. D. (1994). Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl. Acad. Sci. USA 91, 584-588.
28. Min, K-S., Hatta, A., Onosaka, S., Ohta, N., Okada, Y., and Tanaka, K. (1987). Protective role of renal metallothionein against Cd nephrotoxicity in rats. Toxicol. Appl. Pharmacol. 88, 294-301.
29. Murakami, M., Cain, K., and Webb, M. (1983). Cadmium - metallothionein-induced nephropathy: A morphological and autoradiographic study of cadmium distribution, the development of tubular damage and subsequent cell regeneration. J. Appl. Toxicol. 3, 237-244.
30. Nordberg, G. F., Goyer, R., and Nordberg, M. (1975). Comparative toxicity of cadmium - metallothionein and cadmium chloride on mouse kidney. Arch. Pathol. 99, 192-197.
31. Palmiter, R. D., Sandgren, E. P., Koeller, D. M., and Brinster, R. L. (1993). Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice. Mol. Cell. Biol. 13, 5266-5275.
32. Peterson, J. I., and Young, D. S. (1968). Evaluation of the hexokinase/glucose-6 phosphate dehydrogenase method of determination of glucose in urine. Anal. Biochem. 23, 301-316.
33. Sendelbach, L. E., Kershaw, W. C., Cuppage, F., and Klaassen, C. D. (1992). Cd - metallothionein nephrotoxicity in inbred strains of mice. J. Toxicol. Environ. Health 35, 115-126.
34. Slot, C. (1965). Plasma creatinine determination: A new and specific Jaffe reaction method. Scand. J. Clin. Lab. Invest. 17, 381-387.
35. Squibb, K. S., Pritchard, J. B., and Fowler, B. A. (1984). Cadmium -metallothionein nephropathy: Relationships between ultrastructural/biochemical alterations and intracellular cadmium binding. J. Pharmacol. Exp. Ther. 229, 311-321.
36. Suzuki, C. A. M., and Cherian, M. G. (1989). Renal glutathione depletion and nephrotoxicity of cadmium-metallothionein in rats. Toxicol. Appl. Pharmacol. 98, 544-552.
37. Tietze, F. (1969). Enzymic method for quantitative determination of nanogram amounts of total and oxidized glutathione: Applications to mammalian blood and other tissues. Anal. Biochem. 27, 502-522.
38. Vestergaard, P., and Shaikh, Z. A. (1994). The nephrotoxicity of intravenously administered cadmium - metallothionein: Effect of dose, mode of administration, and preexisting renal cadmium burden. Toxicol. Appl. Pharmacol. 126, 240-247.
39. Webb, M., and Etienne, A. T. (1977). Studies on the toxicity and metabolism of cadmium - thionein. Biochem. Pharmacol. 26, 25-30.