Cys 102 and His 398 are required for bleomycin-inactivating activity but not for hexamer formation of yeast bleomycin hydrolase

Biochemistry

Volumn 35, Issue 33, 1996, Pages 10751-10756

  Pei, Zhendong ^a,c   Sebti, Said M ^a,b  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN; CYSTEINE PROTEINASE; HYDROLASE; BIOPOLYMER; BLEOMYCIN HYDROLASE; CYSTEINE; HISTIDINE; RECOMBINANT DNA;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME STRUCTURE; ESCHERICHIA COLI; GENE EXPRESSION; OLIGOMERIZATION; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SITE DIRECTED MUTAGENESIS; TUMOR RESISTANCE; DRUG ANTAGONISM; ENZYMOLOGY; GENETICS; METABOLISM; MOLECULAR CLONING; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; SACCHAROMYCES CEREVISIAE;

BASE SEQUENCE; BIOPOLYMERS; BLEOMYCIN; CLONING, MOLECULAR; CYSTEINE; CYSTEINE ENDOPEPTIDASES; DNA, RECOMBINANT; ESCHERICHIA COLI; HISTIDINE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; SACCHAROMYCES CEREVISIAE;

EID: 0029664745     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9605447     Document Type: Article

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