O6-Benzylguanine enhances the sensitivity of a glioma xenograft with low O6-alkylguanine-DNA alkyltransferase activity to temozolomide and BCNU

British Journal of Cancer

Volumn 73, Issue 9, 1996, Pages 1049-1052

  Wedge, S R ^a   Newlands, E S ^a  

^a CHARING CROSS HOSPITAL   (United Kingdom)

Author keywords

BCNU; Glioma; O6 alkylguanine DNA alkyltransferase; O6 benzylguanine; Temozolomide

Indexed keywords

6 O ALKYLGUANINE DNA ALKYLTRANSFERASE; 6 O ALKYLGUANINE DNA ALKYLTRANSFERASE INHIBITOR; ALKYLATING AGENT; CARMUSTINE; TEMOZOLOMIDE; ANTINEOPLASTIC AGENT; DACARBAZINE; DRUG DERIVATIVE; GUANINE; METHYLATED DNA PROTEIN CYSTEINE METHYLTRANSFERASE; METHYLTRANSFERASE; O(6) BENZYLGUANINE; O(6)-BENZYLGUANINE;

ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG CYTOTOXICITY; DRUG POTENTIATION; DRUG SENSITIVITY; ENZYME ACTIVITY; GLIOMA; HUMAN; HUMAN CELL; INTRAPERITONEAL DRUG ADMINISTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TUMOR XENOGRAFT; ANIMAL; ASTROCYTOMA; BODY WEIGHT; CELL CULTURE; CELL DIVISION; CELL LINE; DRUG EFFECT; ENZYMOLOGY; GLIOBLASTOMA; KINETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; TIME; XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; ASTROCYTOMA; BODY WEIGHT; CARMUSTINE; CELL DIVISION; CELL LINE; DACARBAZINE; GLIOBLASTOMA; GUANINE; HUMANS; KINETICS; METHYLTRANSFERASES; MICE; MICE, NUDE; O(6)-METHYLGUANINE-DNA METHYLTRANSFERASE; TIME FACTORS; TRANSPLANTATION, HETEROLOGOUS; TUMOR CELLS, CULTURED;

EID: 0029664326     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1996.203     Document Type: Article

References (28)

1. BRADFORD MM. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principles of protein-dye binding. Anal. Biochem., 72, 248-254.
2. CATAPANO CV, BROGGINI M, ERBA E, PONTI M, MARIANI L, CITTI L AND D'INCALCI M. (1987). In vitro and in vivo methazolastone-induced DNA damage and repair in L1210 leukemia sensitive and resistant to chloroethylnitrosoureas. Cancer Res., 47, 4884-4889.
3. DE VITA VT. (1989). Principles of chemotherapy. Cancer. In Principles and Practices of Oncology, De Vita Jr VT, Hellman S, Rosenberg SA. (eds), pp. 276-300. Lippincott: Philadelphia.
4. 6-benzylguanine analogues on sensitivity of human tumor cells to the cytotoxic effects of alkylating agents. Cancer Res., 51, 3367-3372.
5. 6-benzylguanine on the sensitivity of human colon tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). Biochem. Pharmacol., 46, 285-290.
6. 6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL. Cancer Chemother. Pharmacol., 35, 121-126.
7. 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea. Cancer Chemother. Pharmacol., 32, 471-476.
8. FRIEDMAN HS, DOLAN ME, MOSCHEL RC, PEGG AE, FELKER GM, RICH J, SIGNER DD AND SCHOLD JR SC. (1992). Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multi-forme. J. Natl Cancer Inst., 84, 1926-1931.
9. FRIEDMAN HS, DOLAN ME, PEGG AE, MARCELLI S, KEIR S, CATINO JJ, BIGNER DD AND SCHOLD JR SC. (1995). Activity of temozolomide in the treatment of central nervous system tumor xenografts. Cancer Res., 55, 2853-2857.
10. GERAN RI, GREENBERG NH, MACDONALD MM, SCHUMACHER AM AND ABOTT BJ. (1972). Protocols for screening chemical agents and natural products against animal tumors and other biological systems. Cancer Chemother. Rep., 3(2), 47-52.
11. 6-alkylguanine-DNA alkyltransferase. Cancer Res., 46, 1521-1527.
12. 6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) in a human colon cancer xenograft completely resistant to BCNU alone. Biochem. Pharmacol., 45, 483-491.
13. 6-alkylguanine-DNA alkyltransferase depletion and regeneration in human peripheral lymphocytes following dacarbazine and fotemustine. Cancer Res., 51, 619-623.
14. 6-benzylguanine on the sensitivity of human tumor xenografts to 1,3-bis(2-chloroethyl)-1-nitrosourea and on DNA interstrand cross-link formation. Cancer Res., 52, 1171-1175.
15. NEWLANDS ES, BLACKLEDGE GRP, SLACK JA, RUSTIN GJS, SMITH DB, STUART NSA, QUARTERMAN CP, HOFFMAN R, STEVENS MFG, BRAMPTON MH AND GIBSON AC. (1992). Phase I trial of temozolomide (CCRG 81045: M & B 39831: NSC 3628561. Br. J. Cancer, 65, 287-291.
16. O'REILLY SM, NEWLANDS ES, GLASER MG, BRAMPTON M, RICE-EDWARDS JM, ILLINGWORTH RD, RICHARDS PG, KENNARD C, COLQUHOUN IR, LEWIS P AND STEVENS MFG. (1993). Temozolomide: a new oral cytotoxic chemotherapeutic agent with promising activity against primary brain tumours. Eur. J. Cancer, 29A, 940-942.
17. 6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents. Cancer Res., 50, 6119-6129.
18. PLOWMAN J, WAUD WR, KOUTSOUKOS AD, RUBINSTEIN LV, MOORE TD AND GREVER MR. (1994). Preclinical antitumor activity of temozolomide in mice: efficacy against human brain tumor xenografts and synergism with 1,3-bis(2-chloroethyl)-I-nitrosourea. Cancer Res., 54, 3793-3799.
19. PONTEN J AND MACINTYRE EH. (1968). Long term culture of normal and neoplastic glia. Acta Pathol. Microbiol. Scand., 74, 465-486.
20. 6-benzylguanine and hypoxia on the cytotoxicity of 1,3-bis(2-chloroethyl)-I-nitrosourea in nitrosourea-resistant SF-763 cells. Cancer Chemother. Pharmacol., 32, 477-481.
21. 6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain. Cancer Res., 53, 3416-3420.
22. STEVENS MFG, HICKMAN JA, LANGDON SP, CHUBB D, VICKERS L, STONE R, BAIG G, GODDARD C, GIBSON NW, SLACK JA, NEWTON C, LUNT E, FIZAMES C AND LAVELLE F. (1987) Antitumour activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo [5, 1-d]-1,2,3,5-tetrazin-4 (3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine. Cancer Res., 47, 5846-5852.
23. STEWARD DJ. (1989). The role of chemotherapy in the treatment of gliornas in adults. Cancer Treat. Rev., 16, 129-160.
24. 6 alkylation in the mechanism of cytotoxicity of imidazotetrazinones. Biochem. Pharmacol., 36, 457-462.
25. 1-bis(2-chloroethyl)-N-nitrosourea (BCNU). Cancer Res., 42, 3102-3105.
26. 6-benzylguanine: a comparative study in vitro. Br. J. Cancer, 73(4).
27. 6-Alkylguanine-DNA alkyltransferase activity in human brain and brain tumors. Carcinogenesis, 5, 121-124.
28. 6-methylguanine-DNA methyl-transferase in cell survival, mutagenesis and carcinogenesis. Mutat. Res., 145, 1-16.