Effect of a vitamin D3 analog, EB1089, on hematopoietic stem cells from normal and myeloid leukemic blasts

Leukemia

Volumn 10, Issue 11, 1996, Pages 1751-1757

  Lee, Y Y ^a,b   Kim, E S ^b,c   Seol, J G ^b   Kim, B K ^b,c   Binderup, L ^d   Elstner, E ^e   Park, D J ^e   Koeffler, H P ^e  

^a Hanyang University   (South Korea)

^b Seoul National University   (South Korea)

^c Seoul National University Hospital   (South Korea)

^d LEO PHARMA A S   (Denmark)

^e CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

1,25(OH)2D3; Acute myeloid leukemia; CD34+; EB1089; Peripheral blood stem cell transplantation; Purging

Indexed keywords

CALCITRIOL; CD34 ANTIGEN; SEOCALCITOL; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE;

ACUTE GRANULOCYTIC LEUKEMIA; ARTICLE; BLAST CELL; BONE MARROW CELL; CELL CULTURE; CELL GROWTH; CELL PROLIFERATION; CELL STRAIN HL 60; CLONOGENIC ASSAY; COLONY FORMATION; COLONY FORMING UNIT GM; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; HEMATOPOIETIC CELL; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; LEUKEMIA CELL; MYELOID LEUKEMIA; PERIPHERAL BLOOD STEM CELL; PRIORITY JOURNAL; STEM CELL; STEM CELL TRANSPLANTATION; CELL DIVISION; CELL SEPARATION; CYTOLOGY; HEMATOPOIETIC STEM CELL TRANSPLANTATION; MONONUCLEAR CELL; PATHOLOGY;

ANTIGENS, CD34; ANTINEOPLASTIC AGENTS; CALCITRIOL; CELL DIVISION; CELL SEPARATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HL-60 CELLS; HUMANS; LEUKEMIA, MYELOID; LEUKOCYTES, MONONUCLEAR;

EID: 0029662316     PISSN: 08876924     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (39)

1. Koeffler HP. Induction of differentiation of human acute myelogenous leukemia cells: therapeutic implications. Blood 1983; 62: 709-721.
2. 3-induced differentiation in a human myeloid leukemic cell line (HL-60): receptor-mediated maturation to macrophage-like cells. J Cell Biol 1984; 98: 391-398.
3. Bell NH. Vitamin D-endocrine system. J Clin Invest 1985; 76: 1-6.
4. Munker R, Norman AW, Koeffler HP. Vitamin D compounds: effect on clonal proliferation and differentiation of human myeloid cells. J Clin Invest 1986; 78: 424-430.
5. Tanaka H, Abe E, Miyaura C, Kuribayashi T, Konno K, Nishii Y, Suda T. 1-α,25-dihydroxycholecalciferol and a human myeloid leukemia cell line (HL-60). The presence of a cytosol receptor and induction of differentiation. Biochem J 1982; 204: 713-719.
6. Reichel H, Koeffler HP, Norman AW. The role of the vitamin D endocrine system in health and disease. New Engl J Med 1989; 320: 980-991.
7. 3. Proc Natl Acad Sci USA 1981; 78: 4990-4994.
8. 3 and its fluorinated analogues. Cancer Res 1984; 44: 5624-5628.
9. 3 is a potent antileukemic agent with low potential to cause hypercalcemia. Leukemia Res 1994; 6: 453-463.
10. 3: an extraordinary potent inhibitor of leukemic cell growth in vitro. Blood 1994; 84: 1960-1967.
11. 3 prolongs survival time of leukemic mice. Proc Natl Acad Sci USA 1990; 87: 3929-3932.
12. 3 analogues: in vivo and in vitro effects on human preleukemic and leukemic cells. Cancer Treat Rep 1985; 69: 1399-1407.
13. Binderup L, Bramm E. Effects of a novel vitamin D analogue MC903 on cell proliferation and differentiation in vitro and on calcium metabolism in vivo. Biochem Pharmacol 1988; 37: 889-895.
14. 3 analog with potent ability to induce HL-60 cell differentiation without modulating calcium metabolism. Blood 1991; 78: 75-82.
15. Bower M, Colston KW, Stein RC, Hedley A, Gazat J-C, Ford HT, Coombes RC. Topical calcipotriol treatment in advanced breast cancer. Lancet 1991; 337: 701-702.
16. Colston KW, Chander SK, Mackay AG, Coombes RC. Effects of synthetic vitamin D analogues on breast cancer cell proliferation in vivo and in vitro. Biochem Pharmacol 1992; 44: 693-702.
17. Civin CI, Strauss LC, Brovall C, Fackler MJ, Schwartz JF, Shaper JH. Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells. J Immunol 1984; 133: 157-165.
18. Katz F, Tindle RW, Sutherland DR, Greaves MF. Identification of a membrane glycoprotein associated with hemopoietic progenitor cells. Leukemia Res 1985; 9: 191-198.
19. Fina L, Molgaard HV, Robertson D, Bradley MJ, Monaghan P, Delia D, Sutherland DR, Baker MA, Greaves MF. Expression of the CD34 gene in vascular endothelial cells. Blood 1990; 75: 2417-2426.
20. Brown J, Greaves MF, Molgaard HV. The gene encoding the stem cell antigen CD34 is conserved in mouse and expressed in haemopoietic progenitor cell lines, brain, and embryonic fibroblasts. Int Immunol 1991; 3: 175-184.
21. Krause DS, Fackler MJ, Civin CI, May WS. CD34: structure, biology, and clinical utility. Blood 1996; 87: 1-13.
22. + hematopoietic progenitor cells from the peripheral blood of patients with chronic myeloid leukemia, Int J Cell Clon 1991; 9: 474-490.
23. Silvestri F, Banavali S, Yin M, Hulette V, Gopal V, Civin CI, Baccarani M, Preisler HD. CD34 antigen expression of acute myeloid leukemia-colony forming cells. Int J Cell Clon 1992; 10 (Suppl. 1): 98-100.
24. Colston KW, Mackay AG, James SY, Binderup L, Chander S, Coombes RC. EB1089: a new vitamin D analogue that inhibits the growth of breast cancer cells in vivo and in vitro. Biochem Pharmacol 1992; 44: 2273-2280.
25. Mathiasen IS, Colston KW, Binderup L. EB1089, a novel vitamin D analogue, has strong antiproliferative and differentiation inducing effects on cancer cells. J Steroid Biochem Mol Biol 1993; 46: 365-371.
26. James SY, Mackay AG, Binderup L, Colston KW. Effects of a new synthetic vitamin D analogue, EB1089, on the oestrogen responsive growth of human breast cancer cells. J Endocrinol 1994; 141: 555-563.
27. + cord blood. Pediatr Res 1992; 32: 277-281.
28. Lebkowski JS, Schain LR, Okrongly D, Levinsky R, Harvey MJ, Okarma TB. Rapid isolation of human CD34 hematopoietic stem cells-purging of human tumor cells. Transplantation 1992; 53: 1011-1019.
29. 3 analogues: a novel class of potent regulators of cell growth and immune responses. Biochem Pharmacol 1991; 42: 1569-1575.
30. Mehta AB, Kumaran TO, Marsh GW. Treatment of advanced myelodysplastic syndrome with alfacalcidol. Lancet 1984; 2: 761.
31. 3. Am J Hematol 1986; 23: 284-299.
32. Binderup E, Calverly MJ, Binderup L. Synthesis and biological activity of 1α-hydroxylated vitamin D analogues with polyunsaturated side chains. In: Norman AW, Bouillon R, Thomasset M (eds). Vitamin D. Gene Regulation, Structure-Function Analysis and Clinical Application. Walter de Gruyer: Berlin, 1991;pp 192-193.
33. Zhou JY, Norman AW, Lubbert M, Collins ED, Uskokovic MR. Koeffler HP. Novel vitamin D analogues that modulate leukemic cell growth and differentiation with little effect on either intestinal calcium absorption or bone calcium mobilizations. Blood 1989; 74: 82-93.
34. 3: differential effects on leukemic cell growth, differentiation, and intestinal calcium absorption. Cancer Res 1990; 50: 6857-6864.
35. Silvestri F, Banavali S, Baccarani M, Preisler HD. The CD34 hemopoietic progenitor cell associated antigen: biology and clinical applications. Hematologica 1992; 77: 265-272.
36. Krause DS, Fackler MJ, Civin CI, May WS. CD34: structure, biology, and clinical utility. Blood 1996; 87: 1-13.
37. + marrow cells in patients with breast cancer or neuroblastoma. Blood 1991; 77: 1717-1722.
38. Shpall EJ, Jones RB, Bearman SI, Franklin WA, Archer PG, Curiel T, Bitter M, Claman HN, Stemmer SM, Purdy M, Myers SE, Hami L, Taffs S, Heimfeld S, Hallagan J, Berenson RJ. Transplantation of enriched CD34-positive autologous marrow into breast cancer patients following high-dose chemotherapy: influence of CD34-positive peripheral-blood progenitors and growth factors on engraftment. J Clin Oncol 1994; 12: 28-36.
39. + cells to remove circulating tumor cells. Blood 1996; 87: 1625-1634.