GABAB-activated gK+ in thalamic neurons in the lethargic (lh/lh) mouse model of generalized absence seizures

Neuroscience Letters

Volumn 205, Issue 1, 1996, Pages 29-32

  Caddick, Sarah J ^a   Hosford, David A ^a  

^a DURHAM VA MEDICAL CENTER   (United States)

Author keywords

Absence seizures; Conductance (gK+); GABAB; K+; Receptor; Thalamus

Indexed keywords

2 AMINO 5 PHOSPHONOVALERIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 6,7 DINITRO 2,3 QUINOXALINEDIONE; BACLOFEN; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; BICUCULLINE; POTASSIUM CHANNEL;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; MOUSE; NONHUMAN; POTASSIUM CURRENT; PRIORITY JOURNAL; SEIZURE; THALAMUS NUCLEUS; VOLTAGE CLAMP; ABSENCE; ANIMAL; DISEASE MODEL; DRUG EFFECT; MOUSE STRAIN; PATHOPHYSIOLOGY; THALAMUS;

ANIMALS; BACLOFEN; DISEASE MODELS, ANIMAL; EPILEPSY, ABSENCE; MICE; MICE, INBRED STRAINS; POTASSIUM CHANNELS; RECEPTORS, GABA-B; THALAMUS;

EID: 0029662280     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-3940(96)12362-4     Document Type: Article

References (20)

1. Avoli, M. and Gloor, P., Role of thalamus in generalized penicillin epilepsy: observations on decorticated cats, Exp. Neurol., 77 (1982) 386-402.
2. Blanton, M.G., Lo Turco, J.J. and Kriegstein, A.R., Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex, J Neurosci. Methods, 30 (1989) 203-210.
3. Coulter, D.A., Huguenard, J.R. and Prince, D.A., Calcium currents in rat thalamocortical relay neurons: kinetic properties of the transient, low threshold current, J. Physiol, (London), 414 (1989) 587-684.
4. Coulter, D.A., Huguenard, J.R. and Prince, D.A., Cellular actions of petit mal anti-convulsant: implication of thalamic low-threshold calcium current in generation of spike-wave discharge. In M. Avoli, P. Gloor, P. Kostopoulos and R. Naquet (Eds.), Generalized Epilepsy; Neurobiological Approaches, Birkhauser, Boston, 1990, pp. 425-435.
5. B receptor in excitation and inhibition of thalamocortical cells, Trends Neurosci., 14 (1991) 16-21.
6. Deschênes, M., Roy, J.P. and Steriade, M., Thalamic bursting mechanism: an inward slow current revealed by membrane hyperpolarization, Brain Res., 239 (1982) 289-293.
7. Gloor, P. and Fariello, R.G., Generalized epilepsy: some of its cellular mechanisms differ from those of focal epilepsy, Trends Neurosci., 11 (1988) 63-68.
8. B receptor activation in absence seizures of lethargic (lh/lh) mice, Science, 257 (1992) 398-101.
9. Huguenard, J.R. and Prince, D.A., Intrathalamic rhythmicity studied in vitro: nominal T current modulation causes robust anti-oscillatory effects, J. Neurosci., 14(9) (1994) 5485-5502.
10. Jahnsen, H. and Llinás, R., Ionic basis for the electroresponsiveness and oscillatory properties of guinea pig thalamic neurons in vitro, J. Physiol. (London), 349 (1984) 227-247.
11. Jasper, H.H. and Droogleever-Fortuyn, J., Experimental studies of the functional anatomy of the petit mal epilepsy, Res. Publ. Assoc. Res. Nerv. Ment. Disord., 26 (1946) 272-290.
12. Llinás, R. and Jahnsen, H., Electrophysiology of mammalian thalamic neurones in vitro, Nature, 297 (1982) 406-408.
13. B neurotransmission in the control of absence seizures in the rat, Neuroscience, 48 (1992) 87-93.
14. B receptor antagonists: potential new anti-absence drugs, J. Neural Transm. (Suppl.), 35 (1992) 179-188.
15. McCormick, D.A., Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity, Prog. Neurobiol., 39 (1992) 337-388.
16. Ottersen, O.P. and Storm-Mathisen, J., GABA-containing neurons in the thalamus and pretectum of the rodent: an immunocytochemical study, Anat. Histol. Embryol., 170 (1984) 197-207.
17. Steriade, M. and Deschênes, M., The thalamus as a neuronal oscillator, Brain Res. Rev., 8 (1984) 1-31.
18. Steriade, M. and Llinás, R.R., The functional states of the thalamus and the associated neuronal interplay, Physiol. Rev., 68 (1988) 649-742.
19. Steriade, M., McCormick, D.A. and Sejnowski, T.J., Thalamocortical oscillations in the sleeping and aroused brain, Science, 262 (1993) 679-685.
20. Warren, R.A., Agmon, A. and Jones, E.G., Oscillatory synaptic interactions between ventroposterior and reticular neurons in mouse thalamus in vitro, J. Neurophysiol., 72 (1994) 1993-2003.