Effects of A1 adenosine receptor agonist using N6-cyclohexyl-2'-O- methyladenosine in patients with left ventricular dysfunction

Circulation

Volumn 94, Issue 6, 1996, Pages 1212-1215

  Bertolet, Barry D ^a,b   Anand, Inder S ^a   Bryg, Robert J ^a   Mohanty, Pramod K ^a   Chatterjee, Kanu ^a   Cohn, Jay N ^a   Khurmi, Nardev S ^a   Pepine, Carl J ^a  

^a UNIVERSITY OF FLORIDA   (United States)

^b UNIVERSITY OF FLORIDA HEALTH   (United States)

Author keywords

adenosine; atrial natriurette factor; norepinephrine; receptors

Indexed keywords

6 N CYCLOHEXYL 2' O METHYLADENOSINE; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE RECEPTOR; ALDOSTERONE ANTAGONIST; ATRIAL NATRIURETIC FACTOR; NORADRENALIN; PLACEBO; RENIN; ADENOSINE; DRUG DERIVATIVE; HORMONE; N(6) CYCLOHEXYL 2 O METHYLADENOSINE; N(6)-CYCLOHEXYL-2-O-METHYLADENOSINE;

ADRENALIN BLOOD LEVEL; ADULT; ALDOSTERONE BLOOD LEVEL; ARTICLE; BREATHING RATE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; HEART LEFT VENTRICLE FAILURE; HEART RATE; HUMAN; MALE; NEUROMODULATION; NORADRENALIN BLOOD LEVEL; ORAL DRUG ADMINISTRATION; PLASMA RENIN ACTIVITY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; AGED; BLOOD; DRUG EFFECT; DRUG POTENTIATION; ELECTROCARDIOGRAPHY; HEART LEFT VENTRICLE FUNCTION; HEMODYNAMICS; MIDDLE AGED; PATHOPHYSIOLOGY; PHYSIOLOGY;

ADENOSINE; ADULT; AGED; ELECTROCARDIOGRAPHY; FEMALE; HEMODYNAMIC PROCESSES; HORMONES; HUMANS; MALE; MIDDLE AGED; RECEPTORS, PURINERGIC P1; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0029662182     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.6.1212     Document Type: Article

References (13)

1. Belardinelli L, Linden J, Berne RM. The cardiac effects of adenosine. Prog Cardiovasc Dis. 1989;32:73-97.
2. Deckert J, Gleiter CH. Adenosine: an endogenous neuroprotective metabolite and neuromodulator. J Neural Transm Suppl. 1994;43:23-31.
3. 6-endonorboran-2-yl-9-methyladenine) of cardiac A1 adenosine receptor mediated effects in humans. Circulation. 1996;93:1871-1876.
4. Costa F, Biaggioni I. Role of adenosine in the sympathetic activation produced by isometric exercise in humans. J Clin Invest. 1994;93:1654-1660.
5. Costa F, Biaggioni I. Adenosine activates afferent fibers in the forearm, producing sympathetic stimulation in humans. J Pharmacol Exp Ther. 1993;267:1369-1374.
6. Wagner H, Milavec-Krizman M, Gadient F, Menninger K, Schoeffer P, Fozard JR. Species-dependent cardiovascular effects of SDZ-WAG 994, a selective adenosine A1 receptor agonist. Br J Pharmacol. 1994;112:402P.
7. Fozard JR, Menninger K, Tapparelli C. Cardiovascular and metabolic effects of SDZ WAG-994, a selective adenosine A1 receptor agonist, after acute and chronic dosing in the rhesus monkey. Br J Pharmacol. 1994;112:134P.
8. Belardinelli L, Lu J, Dennis D, Martens J, Shryock JC. The cardiac effects of a novel AI-adenosine receptor agonist in guinea pig isolated heart. J Pharmacol Exp Ther. 1994;271:1371-1382.
9. Anand I, Chandrashekhar Y, McCauley A, Siesche S, Berg M, Judd D, Khurmi N, Cohn JN. Cardiovascular and neurohormonal effects of SDZ-WAG 994, a selective adenosine receptor agonist, in man. J Am Coll Cardiol 1995;:127A. Abstract.
10. Massi M, Saija A, Cristalli G, Polidori C, Perfumi M, Costa G. Release of atrial natriuretic factor induced by the A1 adenosine receptor agonist 2-chloro-N6-cyclopentyl-adenosine in the rat. Pharmacol Res. 1992;25:393-402.
11. Hedqvist P, Fredholm BB. Inhibitory effect of adenosine on adrenergic neuroeffector transmission in the rabbit heart. Acta Physiol Scand. 1979;105:120-122.
12. Wakade AR, Wakade TD. Mechanism of presynaptic actions of adenosine and acetylcholine on noradrenaline release in the guinea-pig heart. Neuroscience. 1982;7:2267-2276.
13. Nguyen AH, Nitzsche EU, Gibbs CG, Schelbert H, Middlekauff HR. Evidence for a neuroexcitatory role for adenosine in humans. Circulation. 1995;92(suppl I):I-133. Abstract.