N(G)-nitro-L-arginine methyl ester (L-NAME) prevents tachyphylaxis to local anesthetics in a dose-dependent manner

Anesthesia and Analgesia

Volumn 83, Issue 6, 1996, Pages 1251-1255

  Wilder, Robert T ^a,b   Sholas, Maurice G ^a   Berde, Charles B ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLOROPROCAINE; DIZOCILPINE; LOCAL ANESTHETIC AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; AMINO ACID RECEPTOR BLOCKING AGENT; DIZOCILPINE MALEATE; DRUG DERIVATIVE; ENZYME INHIBITOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEUROPROTECTIVE AGENT; NITRIC OXIDE SYNTHASE; PROCAINE;

ANESTHESIA MECHANISM; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; ENZYME INHIBITION; HYPERALGESIA; INTRAPERITONEAL DRUG ADMINISTRATION; LOCAL ANESTHESIA; MALE; NERVE BLOCK; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SCIATIC NERVE; SPINAL CORD; TACHYPHYLAXIS; ANIMAL; DOUBLE BLIND PROCEDURE; DRUG ANTAGONISM; DRUG EFFECT; HEAT; PATHOPHYSIOLOGY; PHYSIOLOGY; RANDOMIZATION; REACTION TIME; SECOND MESSENGER; SPRAGUE DAWLEY RAT;

ANESTHETICS, LOCAL; ANIMALS; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; ENZYME INHIBITORS; EXCITATORY AMINO ACID ANTAGONISTS; HEAT; HYPERALGESIA; MALE; NERVE BLOCK; NEUROPROTECTIVE AGENTS; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROCAINE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; RECEPTORS, N-METHYL-D-ASPARTATE; SCIATIC NERVE; SECOND MESSENGER SYSTEMS; SPINAL CORD; TACHYPHYLAXIS;

EID: 0029662053     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/00000539-199612000-00021     Document Type: Article

References (24)

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