Up-regulation of D3 dopamine receptor mRNA by neuroleptics

Synapse

Volumn 23, Issue 3, 1996, Pages 232-235

  Wang, Wei ^a,b   Hahn, Kyu Hee ^a   Bishop, John F ^a   Gao, Da Qing ^a,b   Jose, Pedro A ^a,b   Mouradian, M Maral ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

Antipsychotic; Dopamine D3 receptor; Neuroleptic; Polymerase chain reaction

Indexed keywords

CLOZAPINE; DOPAMINE 3 RECEPTOR; HALOPERIDOL; PIMOZIDE; SULPIRIDE; DOPAMINE 2 RECEPTOR; DOPAMINE RECEPTOR BLOCKING AGENT; DRD3 PROTEIN, RAT; MESSENGER RNA; NEUROLEPTIC AGENT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; EXTRAPYRAMIDAL SYMPTOM; GENE EXPRESSION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; PRIORITY JOURNAL; PSYCHOSIS; RAT; ANIMAL; BIOSYNTHESIS; BRAIN LEVEL; METABOLISM; NEOSTRIATUM; NUCLEUS ACCUMBENS; OLFACTORY BULB; OLIGONUCLEOTIDE PROBE; POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; UPREGULATION;

ANIMALS; ANTIPSYCHOTIC AGENTS; BRAIN CHEMISTRY; DOPAMINE ANTAGONISTS; MALE; NEOSTRIATUM; NUCLEUS ACCUMBENS; OLFACTORY BULB; OLIGONUCLEOTIDE PROBES; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RNA, MESSENGER; UP-REGULATION;

EID: 0029659047     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199607)23:3<232::AID-SYN13>3.0.CO;2-0     Document Type: Article

References (15)

1. Bishop, J.F., Mueller, G.P., and Mouradian, M.M. (1994) Alternate 5′ exons in the rat brain-derived neurotrophic factor gene: differential patterns of expression across brain regions. Mol. Brain Res., 26:225-232.
2. 2 receptor mRNA. Brain Res., 564:203-219.
3. 3 receptor mRNA levels in rat brain following antipsychotic treatment. Psychopharmacology, 106:479-483.
4. 3 receptor mRNA levels. Neuropharmacology, 32:901-907.
5. 3 dopamine receptor generated by alternative splicing in the third cytoplasmic loop. J. Biol. Chem., 268:5872-5878.
6. Fishburn, C-S., David, S., Carmon, S., and Fuchs, S. (1994) The effect of haloperidol on D2 dopamine receptor subtype mRNA levels in the brain. FEBS Lett., 339:63-66.
7. 3 dopamine receptor produced through various patterns of alternative splicing. Biochem. Biophys. Res. Commun., 176:1584-1592.
8. 3 receptor mRNA and binding sites in human brain. Mol. Brain Res., 18:187-192.
9. 3 receptor expression suggests the involvement of an anterograde factor from dopamine neurons. Proc. Natl. Acad. Sci. U.S.A., 92:1719-1723.
10. Pagliusi S., Chollet-Daemerius, A., Losberger, C., Mills, A., and Kawashima, E. (1993) Characterization of a novel exon within the D3 receptor gene giving rise to an mRNA isoform expressed in rat brain. Biochem. Biophys. Res. Comm., 194:465-471.
11. 2 receptor mRNA in rat striatum by chronic neuroleptic treatment. Eur. J. Pharmacol., 207:165-168.
12. 3-like receptor mRNA expression in parietal and motor cortices of patients with chronic schizophrenia. Proc. Natl. Acad. Sci. U.S.A., 90:8942-8946.
13. Snyder, L.A., Roberts, J.L., and Sealfon, S.C. (1991) Alternative transcripts of the rat and human dopamine D3 receptor. Biochem. Biophys. Res. Commun., 180:1031-1035.
14. 3) as a target for neuroleptics. Nature, 347:146-151.
15. 3) as a novel target for antipsychotics. Biochem. Pharmacol., 43:659-666.