13C nuclear magnetic resonance detection of interactions of serine hydroxymethyltransferase with C1-tetrahydrofolate synthase and glycine decarboxylase complex activities in arabidopsis

Plant Physiology

Volumn 112, Issue 1, 1996, Pages 207-216

  Prabhu, Vikram ^a   Chatson, K Brock ^b   Abrams, Garth D ^b   King, John ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b NATIONAL RESEARCH COUNCIL CANADA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARABIDOPSIS; ARABIDOPSIS THALIANA; EMBRYOPHYTA;

CARBON; FORMATE TETRAHYDROFOLATE LIGASE; FORMYL METHENYL METHYLENETETRAHYDROFOLATE SYNTHETASE; FORMYL-METHENYL-METHYLENETETRAHYDROFOLATE SYNTHETASE; GLYCINE; GLYCINE CLEAVAGE SYSTEM; GLYCINE DEHYDROGENASE (DECARBOXYLATING); GLYCINE HYDROXYMETHYLTRANSFERASE; HYDROLASE; METHOTREXATE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE; MULTIENZYME COMPLEX; OXIDOREDUCTASE; SERINE; SULFANILAMIDE; SULFANILAMIDE DERIVATIVE;

ARABIDOPSIS; ARTICLE; BINDING SITE; CHEMISTRY; ENZYMOLOGY; KINETICS; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

AMINO ACID OXIDOREDUCTASES; AMINOHYDROLASES; ARABIDOPSIS; BINDING SITES; CARBON ISOTOPES; FORMATE-TETRAHYDROFOLATE LIGASE; GLYCINE; GLYCINE DECARBOXYLASE COMPLEX; GLYCINE DEHYDROGENASE (DECARBOXYLATING); GLYCINE HYDROXYMETHYLTRANSFERASE; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; METHOTREXATE; METHYLENETETRAHYDROFOLATE DEHYDROGENASE (NADP); MULTIENZYME COMPLEXES; SERINE; SULFANILAMIDES;

EID: 0029659032     PISSN: 00320889     EISSN: None     Source Type: Journal    
DOI: 10.1104/pp.112.1.207     Document Type: Article

References (35)

1. Appling DJ (1991) Compartmentation of folate-mediated one-carbon metabolism in eukaryotes. FASEB J 5: 2645-2651
2. Artus NN, Naito S, Somerville CR (1994) A mutant of Arabidopsis thaliana that defines a new locus for glycine decarboxylation. Plant Cell Physiol 35: 879-885
3. Ashworth DJ, Mettler IJ (1984) Direct observation of glycine metabolism in tobacco suspension cells by carbon-13 NMR spectroscopy. Biochemistry 23: 2252-2257
4. Besson V, Neuburger M, Rebeille F, Douce R (1995) Evidence for three serine hydroxymethyltransferases in green leaf cells. Purification and characterization of the mitochondrial and chloroplastic isoforms. Plant Physiol Biochem 33: 665-673
5. Besson V, Rebeille F, Neuburger M, Douce R, Cossins EA (1993) Effects of tetrahydrofolate polyglutamates on the kinetic parameters of serine hydroxymethyltransferase and glycine decarboxylase from pea leaf mitochondria. Biochem J 292: 425-430
6. Brindle K, Fulton S, Sheldon J, Williams S (1995) Probing the properties of enzymes in vivo using NMR. Biochem Soc Trans 23: 376-381
7. 13C-NMR spectroscopy. Plant Physiol 89: 197-203
8. Colas des Francs-Small C, Ambard-Bretteville F, Small ID, Remy R (1993) Identification of a major soluble protein in mitochondria from nonphotosynthetic tissues as NAD-dependent formate dehydrogenase. Plant Physiol 102: 1171-1177
9. 13C NMR studies of acetate metabolism during sporulation of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 80: 5847-5851
10. Gadian DG (1982) Nuclear Magnetic Resonance and Its Applications to Living Systems. Oxford University, Oxford, UK
11. Gifford DJ, Cossins EA (1982a) The nature of formate metabolism in greening barley leaves. Phytochemistry 21: 1479-1484
12. Gifford DJ, Cossins EA (1982b) Relationships between glycollate and formate metabolism in greening barley leaves. Phytochemistry 21: 1485-1490
13. 13C Nuclear magnetic resonance studies of malate and citrate synthesis and compartmentation in higher plant cells. J Biol Chem 268: 3986-3992
14. Kirk CD, Chen L, Imeson HC, Cossins EA (1995) A 5,10-methylene tetrahydrofolate dehydrogenase: 5,10-methenyl tetrahydrofolate cyclohydrolase protein from Pisum sativum. Phytochemistry 39: 1309-1317
15. 13C multiplet resonances of a carboxyl carbon. J Magn Reson 18: 555-557
16. McGuire JJ, Coward JK (1984) Pteroylpolyglutamates: biosynthesis, degradation and function. In RL Blakely, SJ Benkovic, eds, Folates and Pterins, Vol 1. John Wiley & Sons, New York, pp 135-189
17. Nour JM, Rabinowitz JC (1991) Isolation, characterization, and structural organization of 10-formyltetrahydrofolate synthetase from spinach leaves. J Biol Chem 266: 18363-18369
18. Nour JM, Rabinowitz JC (1992) Isolation and sequencing of the cDNA coding for spinach 10-formyltetrahydrofolate synthetase. J Biol Chem 267: 16292-16296
19. Oliver DJ (1981) Formate oxidation and oxygen reduction by leaf mitochondria. Plant Physiol 68: 703-705
20. Oliver DJ (1994) The glycine decarboxylase complex from plant mitochondria. Annu Rev Plant Physiol Plant Mol Biol 45: 323-337
21. 13C NMR detection of folate mediated glycine and serine metabolism. Biochemistry 31: 8713-8719
22. 13C NMR of metabolic flux through the C1-tetrahydrofolate synthase/serine hydroxymethyl transferase enzymes system and effect of antifolate exposure in Saccharomyces cerevisiae. Biochemistry 33: 7166-7173
23. 13C NMR studies of folate mediated serine and glycine metabolism in Arabidopsis (abstract no. 148). Plant Physiol 108: S-43
24. 13C Chemical shifts of 20 free amino acids and their use in detection by NMR of free amino acids in intact plants of Arabidopsis. J Plant Physiol (in press)
25. Prabhu V, Wu K, King J (1994) Folate metabolism in Arabidopsis (abstract no. 672). Plant Physiol 105: S-124
26. Rebeille F, Neuburger M, Douce R (1994) Interaction between glycine decarboxylase, serine hydroxymethyl transferase and tetrahydrofolate polyglutamates in pea leaf mitochondria. Biochem J 302: 223-228
27. Schirch L (1984) Folates in glycine and serine metabolism. In RL Blakely, SJ Benkovic, eds, Folates and Pterins, Vol 1. John Wiley & Sons, New York, pp 399-431
28. Shingles R, Woodrow L, Grodzinski B (1984) Effects of glycolate pathway intermediates on glycine decarboxylation and serine synthesis in pea (Pisum sativum L.). Plant Physiol 74: 705-710
29. Somerville CR, Ogren WL (1981) Photorespiration-deficient mutants of Arabidopsis thaliana lacking mitochondrial serine hydroxymethylase activity. Plant Physiol 67: 666-671
30. 13C]pyruvate in TCA cycle mutants of yeast. Biochemistry 31: 8720-9725
31. Suzuki KT, Cary LW, Kuhlmann KF (1975) Carbon-13 relaxation in doubly labeled sodium acetate. J Magn Reson 18: 390-392
32. Turner S, Ireland R, Morgan C, Rawsthorne S (1992) Identification and localization of multiple forms of serine hydroxymethyltransferase in pea (Pisum sativum) and characterization of a cDNA encoding a mitochondrial isoform. J Biol Chem 267: 13528-13534
33. Walton NJ, Woolhouse HW (1986) Enzymes of serine and glycine metabolism in leaves and non-photosynthetic tissues of Pisum sativum L. Planta 167: 119-128
34. Wu K, Atkinson IJ, Cossins EA, King J (1993) Methotrexate resistance in Datura innoxia. Uptake and metabolism of methotrexate in wild-type and resistant cell lines. Plant Physiol 101: 477-483
35. Wu K, Cossins EA, King J (1994) Folate metabolism in Datura innoxia. In vivo and in vitro folylpolyglutamate synthesis in wild-type and methotrexate-resistant cells. Plant Physiol 104: 373-380