Suppression of p140trkA does not abolish nerve growth factor-mediated rescue of serum-free PC12 cells

Journal of Neurochemistry

Volumn 66, Issue 5, 1996, Pages 1826-1835

  Taglialatela, Giulio ^a   Hibbert, Chris J ^a,b   Hutton, Leslie A ^a   Werrbach Perez, Karin ^a   Perez Polo, J Regino ^a  

^a UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^b UNIVERSITY OF BATH   (United Kingdom)

Author keywords

Aging; Antisense oligonucleotide; Apoptosis; Neurotrophin; p75NGFR ; Tyrosine kinase

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; BRAIN DERIVED NEUROTROPHIC FACTOR; CARBAZOLE DERIVATIVE; K 252; NERVE GROWTH FACTOR; NERVE GROWTH FACTOR RECEPTOR; NEUROTROPHIN 3; ONCOPROTEIN; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE A; ANTISENSE OLIGODEOXYNUCLEOTIDE; DNA FRAGMENT; NEUROTROPHIN;

ANIMAL; APOPTOSIS; ARTICLE; CELL STRAIN; CELL SURVIVAL; CULTURE MEDIUM; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; RAT; AGING; ANIMAL CELL; BINDING SITE; CELL DEATH; CHROMATIN CONDENSATION; DNA BINDING; ENZYME PHOSPHORYLATION; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BRAIN-DERIVED NEUROTROPHIC FACTOR; CARBAZOLES; CELL SURVIVAL; CULTURE MEDIA, SERUM-FREE; MOLECULAR SEQUENCE DATA; NERVE GROWTH FACTORS; NEUROTROPHIN 3; OLIGONUCLEOTIDES, ANTISENSE; PC12 CELLS; PROTO-ONCOGENE PROTEINS; RATS; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKA; RECEPTORS, NERVE GROWTH FACTOR;

EID: 0029658996     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.1996.66051826.x     Document Type: Article

References (71)

1. Aggrawal B. B. (1992) Comparative analysis of the structure and function of TNF-α and TNF-β. Immunol. Ser. 56, 61-78.
2. Akhtar S., Kole R., and Juliano L. R. (1991) Stability of antisense DNA oligodeoxynucleotide analogs in cellular extracts and sera Life Sci. 49, 1793-1801.
3. Barbacid M. (1995) Neurotrophic factors and their receptors. Curr. Opin. Cell Biol. 7, 148-155.
4. Barde Y.-A. (1994) Neurotrophic factors: an evolutionary perspective. J. Neurobiol. 25, 1329-1333.
5. Barker P. A. and Shooter E. M. (1994) Disruption of the NGF binding to the low affinity neurotrophin receptor p75LNTR reduces NGF binding to TrkA on PC12 cells. Neuron 13, 203-215.
6. Barrett G. and Bartlett P. (1994) The p75 nerve growth factor receptor mediates survival or death depending on the stage of sensory neuron development. Proc. Natl. Acad. Sci. USA 91, 6501-6505.
7. Batistatou A. and Greene L. A. (1991) Aurintricarboxylic acid rescues PC12 cells and sympathetic neurons from cell death caused by nerve growth factor deprivation: correlation with suppression of endonuclease activity. J Cell Biol. 115, 461-471.
8. Bellamy C. O. C., Malcomson R. D. G., Harrison D. J., and Wyllie A. H. (1995) Cell death in health and disease: the biology and regulation of apoptosis. Cancer Biol. 6, 3-16.
9. Carson D. A. and Ribeiro J. M. (1993) Apoptosis and disease. Lancet 341, 1251-1254.
10. Chao M. V. (1994) The p75 neurotrophin receptor. J. Neurobiol. 25, 1373-1385.
11. Chao M. V. (1995) Ceramide: a potential second messenger in the nervous system. Mol. Cell. Neurosci. 6, 91-96.
12. Cheng B , Christakos S., and Mattson M. P (1994) Tumor necrosis factor protects neurons against metabolic-excitotoxic insults and promotes maintenance of calcium homeostasis. Neuron 12, 139-153.
13. Dechant G., Rodriguez-Tebar A., and Barde Y. A. (1994) Neurotrophin receptors. Prog. Neurobiol. 42, 347-352.
14. Diaz-Meco M. T., Berra E., Municio M. M., Sanz L., Lozano J., Dominguez I., Diaz-Golpe V., De Lera M. T. L., Alcami J., Paya C. V., Arenzana-Seisdedos F., Virelizier J.-L., and Moscat J. (1993) A dominant negative protein kinase C zeta subspecies blocks NF-kappaB activation. Mol. Cell. Biol. 13, 4770-4775.
15. Diaz-Meco M. T., Dominguez I., Sanz L., Dent P., Lozano J., Municio M. M., Berra E., Hay R. T., Sturgill T. W., and Moscat J. (1994) ζPKC induces phosphorylation and inactivation of IκB-α in vitro. EMBO J. 13, 2842-2848.
16. Dobrowsky R. T., Werner M. H., Castellino A. M., Chao M. V., and Hannun Y. A. (1994) Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor. Science 265, 1596-1599.
17. Dragunow M., Faull R. L. M., Lawlor P., Beilharz E. J., Singleton K., Walker E. B., and Mee E. (1995) In situ evidence for DNA fragmentation in Huntington's disease striatum and Alzheimer's disease temporal lobes. Neuroreport 6, 1053-1057.
18. Gotz R., Koster R., Winkler C., Raulf F., Lottspeich F., Schartl M., and Thoenen H. (1994) Neurotrophin-6 is a new member of the nerve growth factor family. Nature 372, 266-269.
19. Green S. H., Rydel R. E., Connolly J. L , and Greene L. A. (1986) PC12 cells mutants that possess low- but not high-affinity nerve growth factor receptors. J. Cell Biol. 102, 830-843.
20. Greene L. A. and Tischler A. S. (1975) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73, 2424-2428.
21. Greene L. A. and Tischler A. S. (1982) PC12 pheochromocytoma cultures in neurobiological research. Adv. Cell Neurobiol. 3, 373-414
22. Hallbook F., Ibanez C. F , and Persson H. (1991) Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary. Neuron 6, 845-858
23. Hefti F. (1994) Neurotrophic factor therapy for nervous system degenerative diseases. J. Neurobiol. 25, 1418-1435.
24. Heller R. A., Song K., and Fan N. (1993) Cytotoxicity by tumor necrosis factor is mediated by both p55 and p70 receptors. Cell 73, 216.
25. Hempstead B. L., Martin-Zanca D., Kaplan D. R , Parada L. F., and Chao M. V. (1991) High-affinity NGF binding requires coexpression of the trk oncogene and the low-affinity NGF receptor. Nature 350, 678-683.
26. Hohn A., Leibrock J., Bailey K., and Barde Y. A. (1990) Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature 344, 339-341.
27. Ip N. Y. and Yancopoulos G. D. (1994) Neurotrophic factors and their receptors. Ann. Neurol. 35 (Suppl.), S13-S16.
28. Ip N. Y., Stitt T. N., Tapley P., Klein R., Glass D. J., Fandl J., Greene L. A., Barbacid M., and Yancopoulos G. D. (1993) Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and non-neuronal cells. Neuron 10, 137-149.
29. Joseph R., Li W., and Han E. (1993) Neuronal death, cytoplasmic calcium and internucleosomal DNA fragmentation: evidence for DNA fragments being released from cells. Mol Brain Res. 17, 70-76.
30. Kaplan D. R., Hempstead B. L., Martin-Zanca D., Chao M. V., and Parada L. F. (1991) The trk proto-oncogene product: a signal transducing receptor for NGF. Science 252, 554-558.
31. Kolesnick R. and Fuks Z. (1995) Ceramide: a signal for apoptosis or mitogenesis? J. Exp. Med. 181, 1949-1952.
32. Lamballe F., Klein R., and Barbacid M. (1991) TrkC, a new member of the trk family of tyrosine protein kinases, is a receptor for NT-3. Cell 66, 967-979.
33. Leibrock J., Lottspeich A. H., Hofer M., Hengerer B., Masiakowski P., Thoenen H., and Barde Y. A. (1989) Molecular cloning and expression of brain-derived neurotrophic factor. Nature 341, 149-152.
34. Levi A., Biocca S., Cattaneo A., and Calissano P. (1988) The mode of action of nerve growth factor in PC12 cells. Mol. Neurobiol. 2, 201-225.
35. Levi-Montalcini R. (1966) The nerve growth factor: its mode of action on sensory and sympathetic nerve cells. Harvey Lect. 60, 217-259.
36. Levi-Montalcini R. (1987) The nerve growth factor 35 years later. Science 231, 1154-1162.
37. Loeh D. M. and Greene L. A (1993) Transfection with trk restores "slow" NGF binding, efficient NGF uptake, and multiple NGF responses to NGF-nonresponsive PC12 cell mutants. J. Neurosci. 13, 2919-2929.
38. Maisonpierre P. C., Belluscio L., Squinto S., Ip N. Y., Furth M. E., Lindsay R. M., and Yancopoulos G. D. (1990) Neurotrophin-3: a neurotrophic factor related to NGF and BDNF Science 247, 1446-1451.
39. Maness L. M., Kastin A. J., Weber J. T., Banks W. A., Beckman B. S., and Zadina J. E. (1994) The neurotrophins and their receptors: structure, function, and neuropathology. Neurosci. Biobehav. Rev. 18, 143-159.
40. Martin D. P., Schmidt R. E., DiStefano P. S., Lowry O. H , Carter J. G., and Johnson E. M. Jr. (1988) Inhibitors of protein synthesis and RNA synthesis prevent neuronal death caused by nerve growth factor deprivation. J. Cell Biol. 196, 829-844.
41. Meakin S. O. and Shooter E. M. (1992) The nerve growth factor family of receptors. Trends Neurosci. 15, 323-330.
42. Mesner P. W., Winters T. R., and Green S. H. (1992) Nerve growth factor withdrawal-induced cell death in neuronal PC12 cells resembles that in sympathetic neurons. J. Cell Biol. 6, 1669-1680.
43. Muller G., Ayoub M., Stortz P., Rennecke J., Fabbro D., and Pfizenmaier K. (1995) PKC ζ is a molecular switch in signal transduction of TNF-α, bifunctionally regulated by ceramide and arachidonic acid. EMBO J. 14, 1961-1969.
44. Nakanishi H., Brewer K. A., and Exton J. H. (1993) Activation of the ζ isozyme of protein kinase C by phosphatidylinositol 3,4,5-triphosphate. J. Biol. Chem. 268, 13-16.
45. Obeid L. M., Linardic C. M., Karolak L. A., and Hannun Y. A. (1993) Programmed cell death induced by ceramide. Science 259, 1769-1771.
46. Olivie A. R. and Parker P. J. (1992) Identification of multiple PKC isoforms in Swiss 3T3 cells: differential down-regulation by phorbol ester. J. Cell. Physiol. 152, 240-244.
47. Olson L. (1994) NGF and the treatment of Alzheimer's disease. Exp. Neurol. 124, 5-15.
48. Oltvai Z. N and Korsmeyer S. J. (1994) Checkpoints of dueling dimers foil death wishes. Cell 79, 189-192.
49. Oppenheim R. W. (1991) Cell death during development of the nervous system. Annu. Rev. Neurosci. 14, 453-501.
50. Oppenheim R. W., Prevette D., Tytell M , and Homma S. (1990) Naturally occurring and induced neuronal cell death in the chick embryo in vivo requires protein and RNA synthesis: evidence for the role of cell death genes. Dev. Biol 138, 104-113.
51. Perez-Polo J. R., Foreman P. J., Jackson J. R., Shan D. E., Taglialatela G., Thorpe L. W., and Werrbach-Perez K. (1990) Nerve growth factor and neuronal cell death. Mol. Neurobiol. 4, 57-91.
52. Pushkareva M., Obeid L., and Hannun Y. A. (1995) Ceramide: an endogenous regulator of apoptosis and growth suppression. Immunol. Today 16, 294-297.
53. NGFR involved in developmental neural cell death? Dev. Neurosci. 16, 207-211.
54. Rabizadeh S., Oh J., Zhong L. T., Yang J., Bitler C. M., Butcher L. L., and Bredesen D. E. (1993) Induction of apoptosis by the low-affinity NGF receptor. Science 261, 345-348.
55. Roesl F. (1992) A simple and rapid method for detection of apoptosis in human cells. Nucleic Acids Res. 20, 5243.
56. Schutze S., Potthoff K., Machleidt T., Berkovic D., Weigmann K., and Kronke M. (1992) TNF activates NF-κB by phosphatidylcholine-specific phospholipase C-induced "acidic" sphingomyelin breakdown. Cell 71, 765-776.
57. Schwartzman R. A. and Cidlowski J. A. (1993) Apoptosis: the biochemistry and molecular biology of programmed cell death. Endocr. Rev. 14, 133-151.
58. Shoji Y., Akhtar S., Periasami A., Herman B., and Juliano R. L. (1991) Mechanism of cellular uptake of modified oligodeoxynucleotides containing methylphosphonate linkages. Nucleic Acids Res. 19, 5543-5550.
59. Smith C., Davis T., Anderson D., Solam L., Beckmann M. P., Jerzy R., Dower S. K., Cosman D., and Goodwin R. G. (1990) A receptor for tumor necrosis factor defines an unusual family of cellular and viral proteins. Science 248, 1019-1023.
60. Smith C., Farrah H., and Goodwin R. (1994) The TNF receptor superfamily of cellular and viral proteins: activation, costimulation, and death. Cell 76, 959-962.
61. Squinto S. C., Stitt T. N., Aldrich T. H., Davius S., Bianco S. M., Radziejewski C., Glass D. J., Masiakowski P., Furth M. E., Valenzuela D. M., DiStefano P. S., and Yancopoulos G. D. (1991) TrkB encodes a functional receptor for BDNF and NT-3 but not NGF. Cell 65, 885-893.
62. Stein C. A., Tonkinson L. J., and Yakubov L. (1991) Phosphorothioate oligodeoxynucleotides anti-sense inhibitors of gene expression? Pharmacol. Ther. 52, 365-384.
63. 125I-β-Nerve growth factor binding is reduced in rat brain after stress exposure. J. Neurosci. Res. 25, 331-335.
64. Taglialatela G., Angelucci L., Ramacci M T., Werrbach-Perez K., Jackson G. R., and Perez-Polo J. R. (1991) Acetyl-l-carnitine enhances the response of PC12 cells to nerve growth factor. Dev. Brain Res. 59, 221-230.
65. Taglialatela G., Angelucci L., Ramacci M. T., Werrbach-Perez K., Jackson G. R., and Perez-Polo J. R. (1992) Stimulation of nerve growth factor receptors in PC12 by acetyl-l-carnitine. Biochem. Pharmacol 44, 577-585.
66. Talley A. K., Dewhurst S., Perry S. W., Dollard S. C., Gummuluru S., Fine S. M., New D., Epstein L. G., Gendelman H. E., and Gelbard H. A. (1995) Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crm-a. Mol. Cell. Biol. 15, 2359-2366.
67. Taniuchi M., Schweitzer J. B., and Johnson E. M. (1986) Nerve growth factor receptor molecules in rat brain. Proc. Natl. Acad. Sci. USA 83, 1950-1954.
68. Thompson C. B. (1995) Apoptosis in the pathogenesis and treatment of disease. Science 267, 1456-1462.
69. Tong L. and Perez-Polo J. R. (1995) Transcription factor DNA binding activity in PC12 cells undergoing apoptosis after glucose deprivation. Neurosci. Lett. 191, 137-140
70. Wyllie A. H., Kerr J F. R., and Currie A. R. (1980) Cell death: the significance of apoptosis. Int. Rev. Cytol. 68, 251-306.
71. Wyllie A., Morris R. G., Smith L., and Dunlop D. (1984) Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence of macromolecular synthesis. J. Pathol. 142, 67-77.