NG-nitro-L-arginine methyl ester reduces senna- and cascara-induced diarrhoea and fluid secretion in the rat

European Journal of Pharmacology

Volumn 301, Issue 1-3, 1996, Pages 137-142

  Izzo, Angelo A ^a   Gaginella, Timothy S ^a,b   Mascolo, Nicola ^a   Borrelli, Francesca ^a   Capasso, Francesco ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

Author keywords

Anthraquinone; Cascara; Intestinal secretion; Laxative; Nitric oxide (NO); Senna

Indexed keywords

ARGININE; CASCARA; DEXTRO ARGININE; LAXATIVE; N(G) NITRO DEXTRO ARGININE METHYL ESTER; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; ENZYME INHIBITOR; NITRIC OXIDE SYNTHASE; SENNA EXTRACT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIARRHEA; DRUG INHIBITION; FLUID TRANSPORT; INTESTINE SECRETION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; SENNA; ANIMAL; BODY FLUID; CHEMICALLY INDUCED DISORDER; COLON; DRUG ANTAGONISM; DRUG EFFECT; SECRETION; WISTAR RAT;

ANIMALS; BODY FLUIDS; CASCARA; CATHARTICS; COLON; DIARRHEA; ENZYME INHIBITORS; MALE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; RATS; RATS, WISTAR; SENNA EXTRACT;

EID: 0029658987     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/0014-2999(96)00023-4     Document Type: Article

References (27)

1. Beubler, E. and G. Kollar, 1988, Prostaglandin-mediated action of sennosides, Pharmacology 36 (Suppl. 1), 85.
2. Beubler, E. and A. Schirgi-Degen, 1993, Serotonin antagonists inhibit sennoside-induced fluid secretion and diarrhea, Pharmacology 47 (Suppl. 1), 64.
3. Capasso, F., N. Mascolo, G. Autore and V. Romano, 1986, Laxatives and the production of autacoids by rat colon, J. Pharm. Pharmacol. 38, 627.
4. 2+ dependence, Gastroenterology 87, 503.
5. Gaginella, T.S., 1994, Laxative Drugs, Textbook of Human Pharmacology (Chapman-Hall, New York) p. 1075.
6. Gaginella, T.S. and P. Bass, 1978, Laxative: an update on mechanism of action. Life Sci. 23, 1001.
7. Gaginella, T.S., N. Mascolo, A.A. Izzo, G. Autore and F. Capasso, 1994, Nitric oxide as mediator of bisacodyl and phenolphthalein laxative action: induction of nitric oxide synthase, J. Pharmacol. Exp. Ther. 270, 1239.
8. Grider, J.R., 1993, Interplay of VIP and nitric oxide in regulation of the descending relaxation phase of peristalsis. Am. J. Physiol. 264, G334.
9. Gullikson, G.W. and P. Bass, 1984, Mechanism of action of laxative drugs, Ch. 28, Pharmacology of Intestinal Permeation. II, p. 419.
10. Izzo, A.A., T.S. Gaginella, N. Mascolo and F. Capasso, 1994, Nitric oxide as a mediator of the laxative action of magnesium sulphate, Br. J. Pharmacol. 113, 228.
11. Kostka, P., E. Jan, E.G. Watson, J.L. Steward and E.E. Daniel, 1993, Nitric oxide synthase in the automatic nervous system of canine ileum, J. Pharmacol. Exp. Ther. 264, 234.
12. Lemli, J. and L. Lemmens, 1980, Metabolism of sennosides and rhein in the rat. Pharmacology 20 (Suppl. 1), 50.
13. Marletta, M.A., 1993, Nitric oxide synthase structure and mechanism, J. Biol. Chem. 268, 12231.
14. Mascolo, N., A.A. Izzo, F. Barbato and F. Capasso, 1993, Inhibitors of nitric oxide synthetase prevent castor oil-induced diarrhoea in the rat, Br. J. Pharmacol. 108, 861.
15. Mascolo, N., T.S. Gaginella, A.A. Izzo, G. Di Carlo and F. Capasso, 1994, Nitric oxide involvement in sodium choleate-induced fluid secretion and diarrhoea in rats, Eur. J. Pharmacol. 264, 21.
16. Miller, M.J.S., H. Sadowska-Krowicka, S. Chotinaruemol, J.L. Kakkis and D.A. Clark, 1993a, Amelioration of chronic ileitis by nitric oxide synthase inhibition, J. Pharmacol. Exp. Ther. 268, 291.
17. Miller, M.J.S., X.J. Zhang, H. Sadowska-Krowicka, S. Chotinaruemol, J.A. McIntyre, D.A. Clark and S.A. Bustamante, 1993b, Nitric oxide release in response to gut injury, Scand. J. Gastroenterol. 28, 149.
18. Moncada, S. and A. Higgs, 1993, Mechanism of disease: the L-arginine-nitric oxide pathway, New Engl. J. Med. 329, 2002.
19. Mourad, F.H., L.J.D. O'Donnell, M.L. Clark and M.J.G. Farthing, 1993, L-Arginine induces water secretion in rat jejunum in vivo, Gastroenterology 104, A 226.
20. Nichols, K., W. Staines and A. Krantis, 1993, Nitric oxide synthase distribution in the rat intestine: a histochemical analysis, Gastroenterology 105, 1651.
21. Rao, R.K., P.J.M. Riviere, X. Pascaud, J.L. Junien and F. Porreca, 1994, Tonic regulation of mouse ileal ion trasport by nitric oxide, J. Pharmacol. Exp. Ther. 269, 626.
22. Sanders, K.M. and S.M. Ward, 1992, Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission. Am. J. Physiol. 262, G379.
23. Schirgi-Degen, A. and E. Beubler, 1995, Significance of nitric oxide in the stimulation of intestinal fluid absorption in the rat jejunum in vivo, Br. J. Pharmacol, 114, 13.
24. Tamai, H. and T.S. Gaginella, 1993, Direct evidence for nitric oxide stimulation of electrolyte secretion in the rat colon. Free Rad. Res. Commun. 19, 229.
25. Van Os, F.H.L., 1976, Some aspects of the pharmacology of anthraquinone drugs. Pharmacology 14 (Suppl. 1), 18.
26. Verhaeren, E., 1980, Mitochondrial uncoupling activity as a possible base for a laxative and antipsoriatic effect. Pharmacology 20 (Suppl. 1), 43.
27. Wilson, K.T., Y. Xie, M.W. Musch and E.B. Chang, 1993, Sodium nitroprusside stimulates anion secretion and inhibits sodium chloride absorption in rat colon, J. Pharmacol. Exp. Ther. 266, 224.