Detection of P-glycorotein expression by tumoral cells with NBDL-CsA, a fluorescent derivative of cyclosporin A

Anti-Cancer Drugs

Volumn 7, Issue 3, 1996, Pages 257-265

  Didier, A ^a   Tiberghien, F ^a   Wenger, R ^b   Loor, F ^a,b  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b Sandoz Pharma Ltd   (Switzerland)

Author keywords

Cyclosporin A efflux; Multidrug resistance; P glycoprotein; SDZ PSC 833

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOSPORIN A; CYCLOSPORIN DERIVATIVE; DAUNORUBICIN; DOXORUBICIN; FLUORESCENT DYE; GLYCOPROTEIN P; SDZ 217881; SDZ 280446; UNCLASSIFIED DRUG; VALSPODAR; VINBLASTINE SULFATE; (N 5 (4 NITROBENZOFURAZAN 7 YL)LYSYL(8))CYCLOSPORINE; (N-5-(4-NITROBENZOFURAZAN-7-YL)LYSYL(8))CYCLOSPORINE; CYCLOSPORIN; VINBLASTINE;

ANIMAL CELL; ARTICLE; CELL CULTURE; CONTROLLED STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; COMPARATIVE STUDY; DRUG EFFECT; DRUG POTENTIATION; DRUG RESISTANCE; METABOLISM;

ANTINEOPLASTIC AGENTS; CYCLOSPORINE; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; FLOW CYTOMETRY; FLUORESCENT DYES; HUMANS; P-GLYCOPROTEIN; TUMOR CELLS, CULTURED; VINBLASTINE;

EID: 0029658974     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-199605000-00004     Document Type: Article

References (22)

1. Higgins C. ABC Transporters: from microorganisms to man. Annu Rev Cell Biol 1992; 8: 67-113.
2. Gros P, Buschman E. The mouse multidrug resistance gene family: structural and functional analysis. Int Rev Cytology 1993; 137C: 169-97.
3. Moscow JA, Schneider E, Cowan KH. Multidrug resistance. In: Pinedo HM, Longo DL, Chabner BA, eds. Cancer chemotherapy and biological modifyers 15. Amsterdam: Elsevier 1994: 99-129.
4. Loor F. Cyclosporins and related fungal products in the reversal of P-glycoprotein-mediated multidrug resistance. In: Gupta S, Tsuruo T, eds Multidrug resistance in cancer cells: cellular, biochemical, molecular and biological aspects. Chichester: John Wiley 1996, in press.
5. Boesch D, Loor F. Extent and persistence of P-glycoprotein inhibition in multidrug-resistant P388 cells after exposure to resistance-modifying agents. Anti-Cancer Drugs 1994; 5: 229-38.
6. Didier A, Wenger J, Loor F. Decreased uptake of cyclosporin A by P-glycoprotein (P-gp) expressing CEM leukemic cells and restoration of normal retention by P-gp blockers. Anti-Cancer Drugs 1995; 6: 669-80.
7. Schramm U, Fricker G, Wenger R, et al. P-glycoprotein-mediated secretion of a fluorescent cyclosporin analogue by teleost renal proximal tubules. Am J Physiol 1995; 268: F46-52.
8. Gavériaux C, Boesch D, Jachez B, et al. SDZ PSC 833, a non immunosuppressive cyclosporin analog, is a very potent multidrug-resistance modifier. J Cell Pharmacol 1991; 2: 225-34.
9. Bommhardt U, Cerottini J-C, MacDonald HR. Heterogeneity in P-glycoprotein (multidrug resistance) activity among murine peripheral T cells: correlation with surface phenotype and effector function. Eur J Immunol 1994; 24: 2974-81.
10. Schlaifer D, Laurent G, Chittal S, et al. Immunohistochemical detection of multidrug resistance associated P-glycoprotein in tumour and stromal cells of human cancer. Br J Cancer 1990; 62: 177-82.
11. + T cells: a role in cytotoxic effector function. J Clin Immunol 1992; 12: 451-8.
12. Wilisch A, Noller A, Handgretinger R, et al. MDR1/P-glycoprotein expression in natural killer (NK) cells enriched from peripheral or umbilical cord blood. Cancer Lett 1993; 69: 139-48.
13. Cordon-Cardo C. Biological and clinical implications of P-gp expression in normal and tumor cells. In: Gupta S, Tsuruo T, eds. Multidrug resistance in cancer cells: cellular, biochemical, molecular and biological aspects Chichester: John Wiley 1996, in press.
14. Cordon-Cardo C, O'Brien JP, Casals D, et al. Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites. Proc Natl Acad Sci USA 1989; 86: 695-8.
15. Tatsuta T, Naito M, Oh-Hara T, et al. Functional involvement of P-glycoprotein in blood-brain barrier. J Biol Chem 1992; 267: 20383-91.
16. Ueda K, Okamura N, Tanigawara T, et al. Human P-glycoprotein transports cortisol, aldosterone and dexamethasone, but not progesterone. J Biol Chem 1992; 267: 24249-52.
17. Yang C, DePinho SG, Greenberger LM, et al. Progesterone interacts with P-glycoprotein in multidrug-resistant cells and in the endometrium of gravid uterus. J Biol Chem 1989; 264: 782-8.
18. Augustijns PF, Bradshaw TP, Gan LL, et al. Evidence for a polarized efflux system in CACO-2 cells capable of modulating cyclosporin A transport. Biochem Biophys Res Comm 1993; 197: 360-5.
19. Saeki T, Ueda K, Tanigarawa Y, et al. Human P-glycoprotein transports cyclosporin A and FK506. J Biol Chem 1993; 268: 6077-80.
20. Shirai A, Naito M, Tatsuta T, et al. Transport of cyclosporin A across the brain capillary endothelial cell monolayer by P-glycoprotein. Biochim Biophys Acta 1994; 1222: 400-4.
21. Didier A, Loor F. Decreased biotolerability for ivermectin and cyclosporin A in mice exposed to potent P-glycoprotein inhibitors. Int J Cancer 1995; 63: 263-7.
22. Pourtier-Manzanedo A, Didier AD, Muller CD, et al. SDZ PSC 833 and SDZ 280-446 are the most active of various resistance-modifying agents in restoring rhodamine-123 retention within multidrug resistant P388 cells. Anti-Cancer Drugs 1992; 3: 419-25.