Comparison of the uptake of [3H]-gabapentin with the uptake of L-[3H]-leucine into rat brain synaptosomes

British Journal of Pharmacology

Volumn 118, Issue 3, 1996, Pages 449-456

  Thurlow, Richard J ^a,b   Hill, David R ^a,c   Woodruff, G N ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Gabapentin; Large neutral amino acid uptake; Rat brain; Synaptosomes; System L

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANTICONVULSIVE AGENT; GABAPENTIN; GLUTAMIC ACID; GLUTAMINE; GLYCINE; LEUCINE; RADIOPHARMACEUTICAL AGENT; 4 AMINOBUTYRIC ACID; ACETIC ACID DERIVATIVE; AMINE; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE;

AMINO ACID TRANSPORT; ANIMAL TISSUE; ARTICLE; BRAIN SYNAPTOSOME; COMPETITIVE INHIBITION; DRUG BINDING; DRUG INHIBITION; DRUG UPTAKE; MICHAELIS CONSTANT; NONHUMAN; PRIORITY JOURNAL; RAT; TEMPERATURE SENSITIVITY; ANIMAL; BRAIN; DOSE RESPONSE; DRUG EFFECT; METABOLISM; SYNAPTOSOME; TEMPERATURE; TIME;

ACETIC ACIDS; AMINES; ANIMALS; ANTICONVULSANTS; BRAIN; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GAMMA-AMINOBUTYRIC ACID; LEUCINE; RATS; SYNAPTOSOMES; TEMPERATURE; TIME FACTORS;

EID: 0029658958     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15424.x     Document Type: Article

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